A5100679330- Gene expression and cancer classification
- Synthesis and bioactivity of alkaloids
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Yersinia bacterium, plague, ectoparasites research
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genomics and Chromatin Dynamics
- Microscopic Colitis
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Cholinesterase and Neurodegenerative Diseases
Second Affiliated Hospital of Zhejiang University
2007-2025
Dalian Institute of Chemical Physics
2024-2025
Chinese Academy of Sciences
2024-2025
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Chongqing Technology and Business University
2024
Chongqing University of Posts and Telecommunications
2024
University of Oxford
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
Studies have suggested that cognitive processes such as working memory and temporal control contribute to motor sequence learning. These engage overlapping brain regions with learning, but concrete evidence has been lacking. In this study, we determined whether limits in visuospatial capacity abilities affect the organization of explicitly acquired sequences. Participants performed an explicit learning task, a continuous tapping timing task. We found capacity, not CV from correlated rate...
MicroRNAs (miRNAs) have been suggested to play a vital role in tumor initiation and progression by negatively regulating oncogenes suppressors. Quite recently, studies identified some miRNAs operating promote or suppress invasion metastasis via metastasis-related genes, providing potential therapeutic targets on anti-metastasis strategy. Metastasis-associated colon cancer-1 (MACC1) has newly express highly colorectal cancer (CRC) through transactivating metastasis-inducing HGF/MET signaling...
Post-translational modifications have been identified to be of great importance in cancers and lysine acetylation, which can attract the multifunctional transcription factor BRD4, has as a potential therapeutic target. In this paper, we identify that BRD4 an important role colorectal cancer; its inhibition substantially wipes out tumor cells. Treatment with inhibitor MS417 potently affects cancer cells, although such effects were not always outright necrosis or apoptosis. We report also...
BACKGROUND The aim of this study was to compare the microbiota community structure, assess differences in intestinal bacterial types, and identify metagenomic biomarkers for disparate stages colorectal cancer formation. MATERIAL AND METHODS A total 160 individuals were recruited: 61 cases with non-tumor colon regarded as normal group, 47 histology-substantiated adenomas adenoma 52 invasive adenocarcinomas group. Biopsy on mucosa performed each subject. USEARCH used process sequences data...
Abstract P21‐activated kinase 5 (PAK5) is the recently identified member of group B p21‐activated (PAK) family which are effectors small GTPase Cdc42 and Rac1, known to regulate cell motility activate cell‐survival signaling pathways. However, overexpression PAK5 has not been associated with any cancers so far. Interestingly, we found that was overexpressed in a variety colorectal carcinoma (CRC) lines Western‐blotting examination. Therefore, this study, aim examine expression during CRC...
Recently, Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This aimed to investigate whether GerdQ can be used GERD China.A national multicenter survey was undertaken; all patients who underwent first diagnostic upper endoscopy gastrointestinal (GI) symptoms were included. Data including the gender, age, symptoms, and endoscopic findings prospectively recorded. The score measured...
Variable selection, also known as feature selection in machine learning, plays an important role modeling high dimensional data and is key to data-driven scientific discoveries. We consider here the problem of detecting influential variables under general index model, which response dependent predictors through unknown function one or more linear combinations them. Instead building a predictive model given predictors, we conditional distribution response. This inverse perspective motivates...
Intestinal epithelial tight junction (TJ) is the principal determinant of mucosal permeability, defects which have been correlated to inflammatory bowel disease. In this study, we investigated whether syndecan-1 (Sdc1), predominant cell surface heparan sulfate proteoglycan, affects TJ proteins protect intestinal barrier function. The role Sdc1 in function was examined cultured colonic cells and dextran sodium sulfate–induced colitis mouse model. Barrier determined by transepithelial...
Abstract Background and aim CD24 expression is associated with human colorectal cancer (CRC). Our previous data indicated that promoted the proliferation invasion of cells through activation ERK1/2. Since Src family kinases are frequently deregulated in CRC closely related to MAPK signaling pathway, we investigated impact Lyn, an important member SFKs, on CD24-induced ERK1/2 CRC. Methods Results The interaction Lyn was identified by co-immunoprecipitation (Co-IP) ectopic activation....
Fas signaling has been shown to induce the epithelial-mesenchymal transition (EMT) promote gastrointestinal (GI) cancer metastasis, but involvement of microRNA in this mechanism remains unknown. We found that ligand (FasL) treatment inhibited E-cadherin expression and promoted cell invasion by upregulation miR-23a, overexpression miR-23a inhibitor could partially block activity. FasL-induced extracellular signal-regulated kinase/mitogen-activated protein kinase activated activator 1 (AP-1)...
With the development of artificial intelligence, personalized learning has attracted much attention as an integral part intelligent education. China, United States, European Union, and others have put forward importance in recent years, emphasizing realization organic combination large-scale education training. The a system oriented to learners' preferences suited needs should be accelerated. This review provides comprehensive analysis current situation its key role It discusses research on...
CD24 is a glycosylphosphatidylinositol-anchored membrane protein reported to be overexpressed in human tumorigenesis and progression. Our purpose was determine the role of proliferation colorectal cancer cells potential mechanisms this process. data showed that promoted cell growth induced activation extracellular signal-regulated kinases, Raf-1, p38 mitogen-activated kinase. Furthermore, suppression kinases kinase activity by their specific inhibitors, U0126 SB203580, abrogated CD24-induced...
Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying protein network changes, including cycle gene in cancer, aids understanding molecular mechanism of carcinogenesis identifies characteristic signatures unique for different cancers specific cancer subtypes. The identified can be used diagnosis, prognosis, personalized treatment. During past...
Early diagnosis and treatment of ulcerative colitis (UC) is clinically challenging. To overcome this problem, we explored the interrelated multiplex signaling pathway to identify molecular signatures in UC by using integrated strategy proteomics. Intestinal mucosa 12 cases normal controls underwent comparative proteomic analysis. A total 26 unique differential proteins were identified, including up-regulated 14 down-regulated group. protein cluster, consisting 11 involved p38...
P21-activated protein kinase1 (PAK1), a main downstream effector of small Rho GTPases, Rac1, and Cdc42, plays an important role in the regulation cell morphogenesis, motility, mitosis, angiogenesis. Despite its importance, molecular mechanisms PAK1 that contributed to colorectal carcinogenesis remain unclear. Our immunohistochemistry showed expression was increased with cancer (CRC) progression through adenoma carcinoma sequence. Furthermore, our results suggested relationship between...