A5059431185- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Synthesis and bioactivity of alkaloids
- Pharmacological Effects and Toxicity Studies
- Natural product bioactivities and synthesis
- Venomous Animal Envenomation and Studies
- Synthesis and Biological Evaluation
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Coordination Chemistry and Organometallics
- Thyroid Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Quinazolinone synthesis and applications
- Nuclear Receptors and Signaling
- Phytochemical Studies and Bioactivities
- Traditional Chinese Medicine Analysis
- Plant tissue culture and regeneration
- S100 Proteins and Annexins
- Thyroid Cancer Diagnosis and Treatment
- Botanical Research and Chemistry
- Biological and pharmacological studies of plants
- Synthesis and biological activity
Shanghai University of Traditional Chinese Medicine
2015-2025
Chengdu University of Traditional Chinese Medicine
2023-2025
Central Hospital of Putuo District
2025
Anhui Medical University
2022
Guangdong Academy of Sciences
2020
Institute of Microbiology
2020
Zhoushan Hospital
2020
Yunnan Environmental Protection Bureau
2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015-2018
Traditional medicinal herbs are widely used and may be contaminated with mycotoxigenic fungi during cultivation, harvesting, storage, causing spoilage mycotoxin production. We evaluated the predominant mycoflora extent of contaminations in 48 samples 13 different herbs. In total, 70.8% were slightly aflatoxins (<5 μg kg
Voltage-gated sodium channels are the main targets of antiepileptic drugs, such as valproate (VPA). Single nucleotide polymorphisms (SNPs) in Nav1.6 isoform (SCN8A) have been reported to be closely associated with motor dysfunction pediatric akathisia epileptica. In this study, we conducted a genetic screening patients seizures treated solely VPA and identified two novel missense mutations SCN8A (A1534V Q1853H). Electrophysiological results revealed that peak currents A1534V variant were...
Background: Compound Muniziqi granule (MNZQ), a traditional Uighur medicinal preparation, comprises 13 species of plants.MNZQ is traditionally used for regulating body immunity, modulating inflammation and pain, detoxification, inhibiting tumor growth.This study aims to scientifically evaluate the anti-inflammatory analgesic activities MNZQ, support its clinical use further research with scientific evidence.Methods: The activity MNZQ was evaluated using hot plate test acetic acid-induced...
The gene kcnma1 encodes the α-subunit of high-conductance calcium- and voltage-dependent K+ (BK) potassium channel. With development generation sequencing technology, many KCNMA1 mutants have been identified are more closely related to generalized epilepsy paroxysmal dyskinesia. Here, we performed a genetic screen 26 patients with febrile seizures novel mutation (E155Q). Electrophysiological characterization different in HEK 293T cells, previously-reported R458T E884K variants (not yet...
The pathological process of Parkinson's disease (PD) is closely associated with the death nigral neurons, for which an effective treatment has yet to be found. Lithium, one most widely certified anticonvulsant and mood‑stabilizing agents, exhibits evident neuroprotective effects in epilepsy bipolar disorder. In present study, mechanisms by lithium acts on a chronic 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP) mouse model PD were investigated employing animal behavioral tests,...
An UPLC-MS/MS method was developed to simultaneously determinate vasicine and its main metabolites applied the pharmacokinetic study. In addition, anti-butyrylcholinesterase activity of component in plasma evaluated<italic>in vitro</italic>.
Sodium valproate (VPA) is a broad-spectrum anticonvulsant that effective both in adults and children suffering from epilepsy, but it causes psychiatric behavioral side effects patients with epilepsy. In addition, 30% of epilepsy develop resistance to VPA. At present, regular physical exercise has shown many benefits become an complementary therapy for various brain diseases, including Therefore, we wondered whether VPA combined would be more the treatment seizures associated co-morbidities....
Dingxian pill has been used as an antiepilepsy agent in China from ancient to modern times, of which the concrete pharmacological characterization and underlying molecular mechanism remain unclear. The present study was undertaken investigate them by animal behavior, electroencephalogram (EEG), Morris water maze, immunohistochemistry, transcriptomics, real-time PCR. In our results, treatment dose-dependently inhibited PTZ-induced seizure-like behavior reduced seizure grades, LFP power...
Epilepsy is a chronic disease of brain dysfunction, which arises from imbalance between excitatory and inhibitory activities in neural circuits. Previously, we reported that peptide Martentoxin (MarTX), scorpion Buthus martensii Karsch, displayed antiseizure by specifically inhibiting BK(α + β4) channel currents. Injection MarTX into the hippocampal region mice significantly alleviated convulsive seizures. However, intravenous injection had no antiepileptic efficacy due to blood-brain...
The accessory β1 subunits, regulating the pharmacological and biophysical properties of BK channels, always undergo post-translational modifications, especially glycosylation. To date, it remains elusive whether glycosylation contributes to regulation channels by subunits.Herein, we combined electrophysiological approach with molecular mutations biochemical manipulation investigate function roles N-glycosylation in subunits.The results show that deglycosylation subunits through double-site...