A5086893621- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Cancer Immunotherapy and Biomarkers
- Pesticide Residue Analysis and Safety
- Natural product bioactivities and synthesis
- Pharmacological Effects and Assays
- Phytochemicals and Antioxidant Activities
- Mass Spectrometry Techniques and Applications
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Flavonoids in Medical Research
- Fermentation and Sensory Analysis
- Essential Oils and Antimicrobial Activity
- Metabolomics and Mass Spectrometry Studies
- Postharvest Quality and Shelf Life Management
- Analytical Methods in Pharmaceuticals
- Medicinal Plant Pharmacodynamics Research
- melanin and skin pigmentation
- HIV/AIDS drug development and treatment
- Electrochemical sensors and biosensors
Shanghai University of Traditional Chinese Medicine
2014-2025
Shuguang Hospital
2018-2025
Nanjing University of Chinese Medicine
2025
Jiangsu Province Hospital
2017-2025
China University of Geosciences
2021-2025
Jiangxi Normal University
2021-2024
State Key Laboratory of Food Science and Technology
2007-2024
Nanchang University
2007-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Institute of Hematology & Blood Diseases Hospital
2015-2024
Background & AimsGastric cancer (GC) is a major type characterized by high heterogeneity in both tumor cells and the immune microenvironment (TIME). One intractable GC subtype gastric signet-ring cell carcinoma (GSRCC), which associated with poor prognosis. However, it remains unclear what GSRCC TIME characteristics are how these may contribute to clinical outcomes.MethodsWe enrolled 32 patients advanced of diverse subtypes profiled their using an immune-targeted single-cell profiling...
Background. Leflunomide is an experimental drug with demonstrated ability to prevent and reverse acute allograft xenograft rejection. The two biochemical activities reported for the active metabolite of leflunomide, A77 1726, are inhibition tyrosine phosphorylation dihydroorotate dehydrogenase, enzyme necessary de novo pyrimidine synthesis. These can be distinctly separated in vitro by use uridine, which reverses anti-proliferative effects 1726 caused We report effect uridine on vivo...
During the process of antioxidation tertiary butylhydroquinone (TBHQ) in oil and fat systems, 2-tert-butyl-1,4-benzoquinone (TQ) can be formed. The toxicity TQ was much more than that TBHQ. In work, a normal-phase high-performance liquid chromatography (NP-HPLC) method for accurate simultaneous detection TBHQ edible oils investigated. A C18 column used to separate TQ, gradient elution solutions consisted n-hexane containing 5% ethyl acetate isopropanol. ultraviolet (UV) detector set at dual...
Naoxintong capsule (NXTC) was a famous patent medicine of Traditional Chinese Medicine (TCM) to treat cerebrovascular diseases in China. An LC-MS/MS method developed for simultaneous determination 11 major ingredients (paeoniflorin, ecdysterone, amygdalin, mulberroside A, caffeic acid, ferulic salvianolic acid B, astragaloside IV, formononetin, cryptotanshinone, and tanshinone IIA) NXTC rat plasma. All analytes were separated on an Eclipse plus C18 column using gradient mobile phase system...
ABSTRACT The aim of this study was to investigate the potential mechanism Lu‐Jiao Fang (LJF) inhibiting endothelial‐to‐mesenchymal transition (EndMT) in pressure overload‐induced cardiac fibrosis. Pharmacokinetic behaviors ingredients LJF were evaluated by LC‐MS/MS analysis. Then putative pathways which regulates EndMT analyzed network pharmacology and verified transverse aortic constriction–induced fibrosis rats. Loganin, morroniside, salidroside, isopsoralen, psoralen showed higher plasma,...
Direct and rapid analysis of various elements from solid surfaces under ambient conditions remained a great challenge. In this work, in situ release ionization volatile vapor generation elements...
Phosphorus, a critical biogeochemical element regulating marine productivity, poses analytical challenges in carbonate matrices using conventional spectrophotometric methods. This study establishes novel protocols employing inductively coupled plasma-tandem mass spectrometry...
To observe the skin surface temperature at related back-shu points in patients with different levels of pulmonary ventilation function chronic persistent asthma, and to explore correlation between indexes based on "lung governing hair". Sixty-one level function, were assigned into a reduced group (reduced group, 32 cases) normal (normal 29 cases). In two groups, was measured sites bilateral Feishu (BL13), Geshu (BL17), Pishu (BL20) Shenshu (BL23); (the percentage predicted value forced vital...