A5053396881- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Virus-based gene therapy research
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Viral Infections and Immunology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- NF-κB Signaling Pathways
University of Nottingham
2023
NYU Langone Health
2008-2020
Mount Sinai Health System
2020
New York University
2008-2019
Hinge Health
2019
Columbia University Irving Medical Center
2019
University of North Carolina at Chapel Hill
2019
Dartmouth–Hitchcock Medical Center
2019
Montefiore Medical Center
2017
Stony Brook University
2016
The subgroup C of the adenoviruses (Ad) and group B coxsackieviruses (CVB) are structurally unrelated viruses that known to compete for an unidentified cell surface receptor. We now describe isolation cDNAs from human mouse encode CVB Ad2 5 receptor (HCAR) (MCAR). Both 46-kDa glycoproteins whose primary amino acid sequences highly homologous. Structurally, HCAR MCAR appear be transmembrane proteins contain two extracellular immunoglobulin-like domains therefore belong this superfamily....
Certain mutant strains of herpes simplex virus type 1 (HSV-1) are unable to infect cells in which entry is dependent on HVEM, the previously described herpesvirus mediator designated here as protein A (HveA). These viruses can other where apparently co-receptors. The HSV-1(KOS)Rid1 was used screen a human cDNA expression library for ability transfected plasmids convert resistant Chinese hamster ovary susceptibility entry. plasmid expressing poliovirus receptor-related 2 (Prr2) isolated basis...
Inflammatory bowel disease (IBD) arises from a dysregulated mucosal immune response to luminal bacteria. Toll-like receptor (TLR)4 recognizes LPS and transduces proinflammatory signal through the adapter molecule myeloid differentiation marker 88 (MyD88). We hypothesized that TLR4 participates in innate bacteria development of colitis. TLR4-/- MyD88-/- mice littermate controls were given 2.5% dextran sodium sulfate (DSS) for 5 or 7 days followed by 7-day recovery. Colitis was assessed weight...
Lymphocyte homing, which contributes to inflammation, has been studied extensively in the small intestine, but there is little known about homing large site most commonly affected inflammatory bowel disease. GPR15, an orphan heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor, controlled specific of T cells, particularly FOXP3(+) regulatory cells (Tregs), intestine lamina propria (LILP). GPR15 expression was modulated by gut microbiota and transforming growth...
Glycoprotein D (gD) is a structural component of the herpes simplex virus (HSV) envelope which essential for entry into host cells. Chinese hamster ovary (CHO-K1) cells are one few cell types nonpermissive many HSV strains. However, when these transformed with gene herpesvirus mediator (HVEM), resulting cells, CHO-HVEM12, permissive strains, such as HSV-1(KOS). By virtue its four cysteine-rich pseudorepeats, HVEM member tumor necrosis factor receptor superfamily proteins. Recombinant forms...
Dysregulated innate immune responses to commensal bacteria contribute the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in intestinal mucosa IBD patients and may uncontrolled inflammation. However, also an important mediator repair. The aim this study examine effect a antagonist on inflammation repair two murine models IBD. Colitis was induced C57BL/6J mice with dextran sodium sulfate (DSS) or by transferring CD45Rb(hi) T cells into RAG1-/- mice. An antibody (Ab)...
Patients with ulcerative colitis are at increased risk for developing colorectal cancer. We have shown that Toll-like receptor-4 (TLR4) is overexpressed in human colitis-associated cancer (CAC) and mice deficient TLR4 markedly protected against neoplasia. wished to elucidate the specific contributions of signaling by myeloid cells colonic epithelial (CEC) tumorigenesis.TLR4-deficient or wildtype littermates (WT) were transplanted bone marrow (BM) cells: TLR4(-/-) BM-->WT (TLR4-expressing...
ABSTRACT HVEM (for herpesvirus entry mediator) is a member of the tumor necrosis factor receptor superfamily and mediates many strains herpes simplex virus (HSV) into normally nonpermissive Chinese hamster ovary (CHO) cells. We used sucrose density centrifugation to demonstrate that purified HSV-1 KOS virions bind directly soluble, truncated form (HVEMt) in absence any other cell-associated components. Therefore, HSV by serving as for virus. previously showed forms glycoprotein D (gDt) HVEMt...
Abnormal T cell responses to commensal bacteria are involved in the pathogenesis of inflammatory bowel disease. MyD88 is an essential signal transducer for TLRs response microflora. We hypothesized that TLR signaling via was important effector intestine. expression on murine cells examined by flow cytometry. CD4(+)CD45Rb(high) and/or CD4(+)CD45Rb(low)CD25(+) regulatory were isolated and adoptively transferred RAG1(-/-) mice. Colitis assessed changes body weight histology score. Cytokine...
Summary Two cytochrome P450 2C9 (CYP2C9) polymorphisms, CYP2C9*2 and *3, metabolize warfarin inefficiently. We assessed the extent to which these polymorphisms explain very low dose requirements hemorrhagic complications after excluding non-genetic determinants of dosing. In this retrospective observational study, 73 patients with stable doses for ≥1 month International Normalized Ratios (INR) 2.0–3.0 were enrolled from our Anticoagulation Clinic. Seventeen required ≤2 mg (low-dose), 41 4–6...
Abstract Increasing studies suggest that ceramides differing in acyl chain length and/or degree of unsaturation have distinct roles mediating biological responses. However, still much remains unclear about regulation and role ceramide species the immune response. Here, we demonstrate alkaline ceramidase 3 (Acer3) mediates response by regulating levels C 18:1 -ceramide cells innate system Acer3 deficiency aggravates colitis a murine model augmenting expression pro-inflammatory cytokines...
Aims High‐grade appendiceal mucinous neoplasm (HAMN) was recently proposed as a disease entity histologically analogous to low‐grade (LAMN), but characterised by high‐grade cytological atypia. The pathogenesis and clinical features of HAMN have not been fully elucidated. Methods results Nine cases HAMN, eight LAMN, 10 adenocarcinomas (MACA) five serrated polyps resected between 2008 2017 contributed three medical centres underwent targeted next‐generation sequencing 50 cancer‐related genes....
ABSTRACT The purpose of this study was to determine whether a cell surface protein that can serve as coreceptor for herpes simplex virus type 1 (HSV-1) entry, herpesvirus entry mediator (previously designated HVEM but renamed HveA), also mediates HSV-1-induced cell-cell fusion. We found transfection DNA from KOS-804, previously described HSV-1 syncytial (Syn) strain whose Syn mutation mapped an amino acid substitution in gK, induced numerous large syncytia on HveA-expressing Chinese hamster...