A5066249259- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Genetic factors in colorectal cancer
- Eicosanoids and Hypertension Pharmacology
- Inflammatory Bowel Disease
- HIV/AIDS Research and Interventions
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- Advanced Glycation End Products research
- Inflammatory mediators and NSAID effects
- HIV-related health complications and treatments
- Genetics, Bioinformatics, and Biomedical Research
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Alcohol Consumption and Health Effects
- RNA regulation and disease
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
University of California, San Francisco
2022-2024
Icahn School of Medicine at Mount Sinai
2008-2021
Japan Breast Cancer Research Group
2017
Sanofi (Mexico)
2015
Mount Sinai Medical Center
2015
Chugai Pharma (United States)
2015
Toray Industries, Inc. (Japan)
2015
Mitsubishi Tanabe Pharma Corporation
2015
Yale University
2014
Growing clinical and experimental evidence suggests that sterile inflammation contributes to alcoholic liver disease (ALD). High mobility group box-1 (HMGB1) is highly induced during injury; however, a link between this alarmin ALD has not been established. Thus, the aim of work was determine whether HMGB1 pathogenesis ALD. Liver biopsies from patients with showed robust increase in expression translocation, which correlated stage, compared healthy explants. Similar findings were observed...
Outbreaks of acute hepatitis C virus (HCV) infection are occurring in HIV-infected men who have sex with men. We evaluated risk factors and liver histopathology 11 consecutively enrolled newly acquired HCV that was diagnosed on the basis antibody seroconversion, new elevations alanine aminotransferase level, wide fluctuations RNA level. Ten patients reported unprotected anal intercourse, 7 "club-drug" use, including methamphetamine. Liver biopsy showed moderately advanced fibrosis (Scheuer...
ABSTRACT The hepatitis C virus (HCV) core gene is more conserved at the nucleic acid level than necessary to preserve sequence of protein, suggesting that it contains information for additional functions. We used a battery anticore antibodies test hypothesis directs synthesis protein isoforms. Infectious viruses, replicons, and RNA transcripts expressed p8 minicore containing C-terminal portion p21 lacking N-terminal portion. An interferon resistance mutation, U271A, which creates an AUG...
Abstract Purpose of Review The purpose the article is to review treatment options for patients with AIH whom first-line therapy not successful. We outline recommended approaches providers and new therapies on horizon. Recent Findings Budesonide, while advantageous in some respects, may be as effective predniso(lo)ne. Mycophenolate mofetil most setting azathioprine intolerance less when response has been inadequate. Infliximab biologic agent evidence use AIH. Clinical trials studying...
Plasmacytoid dendritic cells (pDCs) are "natural" interferon α (IFNα)-producing cells. Despite their importance to antiviral defense, autoimmunity, and ischemic liver graft injury, because DC subsets rare heterogeneous, basic questions about pDC function capacity make cytokines remain unanswered. Previous investigations failed consistently detect IFNα mRNA in HCV-infected livers, suggesting that pDCs may be incapable of producing IFNα. We used a combination molecular, biochemical,...
Hepatitis C virus (HCV) is unique among RNA viruses in its ability to establish chronic infection the majority of exposed adults. HCV persists liver despite interferon (IFN)‐stimulated gene (ISG) induction; robust induction actually predicts treatment failure and viral persistence. It unclear which forms are associated with ISG IFN resistance during natural infections. To thoroughly delineate populations, we developed conditions that fully separate strands long double‐stranded (dsRNA) allow...
Abstract Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed phenotype immune cells associated with preservation normal function during C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients undergoing transplantation. Liver peripheral blood mononuclear isolated eight subsets innate delineated by multiparameter flow cytometry. Cytokine assays microarrays performed. Intrahepatic...
Autoimmune hepatitis (AIH) is a severe disease characterized by elevated immunoglobin levels. However, the role of autoantibodies in pathophysiology AIH remains uncertain.
Macrophages are major HIV target cells. They support both productive and latent HIV-1 infection. Susceptibility of primary macrophages to depends on the anatomical location activation state We demonstrate that peritoneal (PMs) abundant in ascitic fluid patients with liver cirrhosis susceptible PMs expressed CD68, a differentiation marker, exhibited phagocytic activity, survived culture for 2 months without additional growth factors. Freshly isolated were R5 strains but not X4-T-cell...
Autoimmune hepatitis (AIH) is a poorly understood, chronic disease, for which corticosteroids are still the mainstay of therapy and most patients undergo liver biopsy to obtain diagnosis. We aimed determine if there was transcriptomic signature AIH in peripheral blood investigate underlying biologic pathways revealed by gene expression analysis. Whole RNA from 75 25 healthy volunteers extracted sequenced. Differential analysis 249 genes that were significantly differentially expressed...
Hepatitis C virus (HCV) is one of the most prevalent causes chronic blood-borne infections worldwide. Despite developments highly effective treatments, infected individuals are unaware their infection. Approximately 75% in low- and middle-income countries; therefore, continuing research HCV molecular virology development vaccines affordable diagnostics required to reduce global burden. Various intracellular forms nucleocapsid (core) protein produced cell culture; these comprise conventional...
How does a scientist produce research results? The answer to the question has changed dramatically over time. Funding is scarce commodity in contemporary world, and this represents major challenge harnessing full potential of human ingenuity life sciences. Scientists
327Ashowed enhanced mitochondrial translocation of JNK accompanied by an increase in the release enzymes, such as apoptosis-inducing factor and endonuclease G, into cytosol, which is indicative increased dysfunction subsequent nuclear DNA fragmentation.Finally, vitro experiments showed that Gab1-deficient hepatocytes were more susceptible to APAP-induced cell death, suggesting hepatocyte Gab1 a direct target hepatotoxicity.Conclusion: Our current data demonstrate plays critical role...
Introduction: Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC). In some estimates, 1 in 300 people have LS, but remain unaware their diagnosis and are typically only diagnosed after they develop cancer. ACG guidelines recommend assessment family history for all patients referral genetic testing when indicated. However, fast-paced nature clinic visits high turnover rate endoscopy units pose significant barriers to this assessment. Methods: We developed a...