A5101658040- Liver Disease Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Gut microbiota and health
- HIV-related health complications and treatments
- Liver Disease and Transplantation
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Inhalation and Respiratory Drug Delivery
- Palliative Care and End-of-Life Issues
- Liver Diseases and Immunity
- Hepatitis C virus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alcohol Consumption and Health Effects
- Vestibular and auditory disorders
- Hepatitis B Virus Studies
- Grief, Bereavement, and Mental Health
- Otolaryngology and Infectious Diseases
- Antimicrobial Resistance in Staphylococcus
- Palliative and Oncologic Care
- HIV/AIDS Research and Interventions
- Photoreceptor and optogenetics research
- Patient Dignity and Privacy
- Hearing Impairment and Communication
- HIV Research and Treatment
- Plant and Biological Electrophysiology Studies
University of California, San Francisco
2019-2025
Max-Planck-Institut für Nachhaltige Materialien
2024
Massachusetts Eye and Ear Infirmary
2017-2019
Harvard University
2017-2018
Eaton (United States)
2018
Brigham and Women's Hospital
2016
United General Hospital
2015
University of Florida
2012
Abstract As hydrogen is touted as a key player in the decarbonization of modern society, it critical to enable quantitative (H) analysis at high spatial resolution and, if possible, atomic scale. H has known deleterious impact on mechanical properties (strength, ductility, toughness) most materials that can hinder their use part infrastructure hydrogen-based economy. Enabling mapping including local concentration analyses specific microstructural features essential for understanding multiple...
Optogenetics is a transformative technology based on light-sensitive microbial proteins, known as opsins, that enable precise modulation of neuronal activity with pulsed radiant energy. has been proposed means to improve auditory implant outcomes by reducing channel interaction and increasing electrode density, but the introduction opsins into cochlear spiral ganglion neurons (SGNs) in vivo challenging. Here we test opsin delivery using synthetically developed ancestral adeno-associated...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people living with HIV. Gut microbial translocation and gut damage may play a role MASLD pathogenesis. We determined associations of circulating biomarkers hepatic steatosis fibrosis large US cohort women HIV (WWH) without Vibration controlled transient elastography (VCTE) was conducted from 2013-2018 among 854 WWH 349 Serum were measured within 6 months the VCTE: kynurenine to tryptophan (KT) ratio,...
Evaluation of resident operative skills is challenging in the fast-paced operating room environment and limited by lack validated assessment metrics. We describe a smartphone-based app that enables rapid skills. Accreditation Council for Graduate Medical Education (ACGME) otolaryngology taxonomy surgical procedures (n = 593) were uploaded to software platform. The was piloted over 1 month. Outcomes included (1) completion evaluation, (2) time spent completing (3) quantification case...
Evaluate the relationship between objective audiometric and vestibular tests patient symptoms in superior canal dehiscence (SCD) syndrome.Retrospective chart review.Tertiary care center.Ninety-eight patients with SCD, preoperative threshold audiograms, cervical evoked myogenic potential (cVEMP) thresholds, computed tomography (CT) imaging were included. Clinical reports reviewed for self-reported SCD symptoms. Twenty-five completed Hearing Handicap Inventory (HHI), Dizziness (DHI), Autophony...
To develop a novel approach combining low-frequency air-bone gap (ABG) and cervical vestibular evoked myogenic potential (cVEMP) thresholds to improve screening for superior canal dehiscence (SCD) syndrome.Retrospective study.Tertiary care center.One hundred forty patients with SCD 21 healthy age-matched controls were included. Ears each patient divided into three groups based on computed tomography (CT) findings: 1) dehiscent, 2) thin, or 3) unaffected.cVEMP audiometric analyzed differences...
Steatohepatitis is common in persons living with HIV and may be associated gut microbial translocation (MT). However, few studies have evaluated the gut-liver axis HIV. In Women's Interagency Study, we examined associations of circulating biomarkers linked to MT damage using FibroScan-aspartate aminotransferase (FAST) score, a noninvasive surrogate for steatohepatitis advanced fibrosis. Among 883 women 354 without HIV, used multivariable regression examine serum (kynurenine tryptophan ratio,...
Otologic methicillin-resistant Staphylococcus aureus (MRSA) infection has historically been rare, but given the rise in community-acquired MRSA carriage and at other body sites, prevalence rates may be changing. The goal of this study was to determine recent otologic cultures from patients with acute otitis externa (AOE).Retrospective review an institutional microbiologic database.A retrospective analysis performed on serial culture isolates taken ear a quaternary care hospital January 2014...
Hepatic steatosis is a leading cause of cirrhosis and hepatocellular carcinoma highly prevalent in persons with HIV (PWH). However, most studies hepatic diagnosis PWH have focused on those at high risk. We determined the accuracy vibration-controlled transient elastography (VCTE) controlled attenuation parameter (CAP) detecting mild or greater as compared noninvasive gold standard magnetic resonance spectroscopy (MRS) PWH.Among 149 participants without HIV, we evaluated test characteristics...
Autoimmune hepatitis (AIH) is a severe disease characterized by elevated immunoglobin levels. However, the role of autoantibodies in pathophysiology AIH remains uncertain.
Abstract Background Due to shared modes of transmission, coinfection with hepatitis B virus (HBV) and C (HCV) is common, HBV vaccination recommended for all persons HCV who remain susceptible HBV. To identify potential gaps in among this high-risk population, we aimed determine the patterns susceptibility undergoing community-based treatment. Methods We performed a cross-sectional study within two treatment programs an urban US setting. Participants were identified screening confirmatory...
Abstract Objective The auditory brain stem implant (ABI) is a neuroprosthesis placed on the surface of cochlear nucleus (CN) to provide hearing sensations in children and adults who are not candidates for implantation. Contemporary ABI arrays stiff do conform curved surface. Recent advancements microfabrication techniques have enabled development flexible arrays, but these only been applied animal models. Herein, we measure curvature human CN adjoining regions assist design placement...
Introduction: Alcohol-associated liver disease (ALD) is the leading indication for transplant (LT) though return to alcohol use occurs up 22% by year 1 and associated with poor post-LT outcomes. While screening along abstinence-promoting behavioral pharmacotherapy foundation in managing disorder (AUD), it underutilized hepatology. We aim examine provider attitudes practice patterns screening/management of patients. Methods: surveyed providers including GI/hep/LT fellows, hep/LT faculty, APP...