A5032654690- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging and Analysis
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced X-ray and CT Imaging
- Motor Control and Adaptation
- Optical Imaging and Spectroscopy Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Hearing Loss and Rehabilitation
- Abdominal vascular conditions and treatments
- Artificial Intelligence in Healthcare and Education
- Acoustic Wave Phenomena Research
- Neural dynamics and brain function
- Cell Image Analysis Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Biliary and Gastrointestinal Fistulas
- Abdominal Surgery and Complications
University Hospital of Geneva
2020-2025
University of St. Gallen
2024
École Polytechnique Fédérale de Lausanne
2020
University of Geneva
2018-2019
Massachusetts Eye and Ear Infirmary
2019
In the field of stroke epidemiology, one major advances in recently implemented International Classification Diseases, 11th revision (ICD-11) relates to definition ischemic stroke, which now includes events shorter than 24 hours when ischemia can be proven on brain imaging. However, data are scarce ascertain incidence strokes short duration with tissue evidence ischemia. this study, we determined incidence, 30-day case fatality, and mortality rate Geneva population using new ICD-11 criteria,...
Prediction of outcome after stroke is critical for treatment planning and resource allocation but complicated by fluctuations during the first days onset. We propose a machine learning model that can provide hourly predictions based on integration continuous variables acquired within 72 h hospital admission.
Physiological evidence suggests that neighboring brain regions have similar perfusion characteristics (vascular supply, collateral blood flow). It is largely unknown whether integrating CT (pCT) information from the area surrounding a given voxel (i.e. receptive field (RF)) improves prediction of infarction this voxel. Based on general linear regression models (GLMs) and using acute pCT-derived maps, we compared added value cuboid RF to predict final infarct. To aim, included 144 stroke...
Intermanual transfer of motor learning is a form generalization that leads to behavioral advantages in various tasks daily life. It might also be useful for rehabilitation patients with unilateral deficits. Little known about neural structures and cognitive processes mediate intermanual transfer. Previous studies have suggested role primary cortex (M1) the supplementary area (SMA). Here, we investigated functional neuroanatomy special emphasis on connectivity within network between regions...
Does the brain become more resilient after a first stroke to reduce consequences of new lesion? Although recurrent strokes are major clinical issue, whether and how prepares for second attack is unknown. This due difficulties obtain an appropriate dataset patients with comparable lesions, imaged at same interval onset. Furthermore, timing event remains unpredictable.Here, we used novel lesion simulation approach test hypothesis that resilience in networks increases during recovery. Sixteen...
OBJECTIVES: Delayed cerebral ischemia (DCI) is a major driver of morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Quantitative pupillometry has been shown to be prognostic value acute neurological injury. However, the evidence for use pupillometric features detection DCI conflicting. The aim this study was investigate frequent monitoring detection. DESIGN: Observational cohort from prospective aSAH registry. SETTING: Tertiary referral center. PATIENTS: Adult patients with confirmed...
Abstract Objective The auditory brain stem implant (ABI) is a neuroprosthesis placed on the surface of cochlear nucleus (CN) to provide hearing sensations in children and adults who are not candidates for implantation. Contemporary ABI arrays stiff do conform curved surface. Recent advancements microfabrication techniques have enabled development flexible arrays, but these only been applied animal models. Herein, we measure curvature human CN adjoining regions assist design placement...
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X20924549 for Integrating regional perfusion CT information to improve prediction of infarction after stroke by Julian Klug, Elisabeth Dirren, Maria G Preti, Paolo Machi, Andreas Kleinschmidt, I Vargas, Dimitri Van De Ville and Emmanuel Carrera in Journal Cerebral Blood Flow & Metabolism
Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely identify the ischemic core and penumbra, but prediction of final infarct remains challenging. With advent machine learning, algorithms learning lesion from imaging data collected in phase have been proposed. We aimed investigate whether methods that integrate prior segmentation improve after stroke. Methodology: retrospectively included all patients admitted Geneva...
Introduction: Endovascular treatment (EVT) is the therapy of choice, in patients with unknown stroke onset (unwitnessed and wake-up strokes) large vessel occlusion (LVO) a favorable perfusion pattern. Whether bridging (intravenous thrombolysis (IVT) EVT) superior to EVT alone remains unknown. Material Methods: We retrospectively included all admitted Geneva University Hospital from 01.2016 06.2020 i) onset, due ii) anterior circulation occlusion, iii) CT pattern based on DEFUSE criteria...
ABSTRACT Background and Purpose Does the brain become more resilient after a first stroke to reduce consequences of new lesion? Although recurrent strokes are major clinical issue, whether how prepares for second attack is unknown. This due difficulties obtain an appropriate dataset patients with comparable lesions, imaged at same interval onset. Furthermore, timing event remains unpredictable. Methods Here we used novel lesion simulation approach test hypothesis that resilience in networks...