A5023016526- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cell Image Analysis Techniques
- Electron and X-Ray Spectroscopy Techniques
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Migraine and Headache Studies
- Cardiac Imaging and Diagnostics
- Scientific Computing and Data Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Syncope and Autonomic Disorders
- MRI in cancer diagnosis
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Semantic Web and Ontologies
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Lanthanide and Transition Metal Complexes
- Cardiovascular Disease and Adiposity
- Biomedical and Engineering Education
- Optical Imaging and Spectroscopy Techniques
- Sparse and Compressive Sensing Techniques
- Cardiovascular Function and Risk Factors
- Mobile Crowdsensing and Crowdsourcing
- Syntax, Semantics, Linguistic Variation
University of Cincinnati
2019-2022
Cincinnati Children's Hospital Medical Center
2014-2022
University of Cincinnati Medical Center
2020-2022
Swarthmore College
2022
Oncology Hematology Care
2019-2020
Siemens Healthcare (United States)
2015
National Institutes of Health
2015
University Hospitals of Cleveland
2011-2012
Case Western Reserve University
2010-2012
University of Michigan
2004-2007
Wavelets are a popular tool for computational harmonic analysis.They provide localization in both the temporal (or spatial) domain as well frequency (Daubechies, 1992).A prominent feature is ability to perform multiresolution analysis (S. Mallat, 2008).The wavelet transform of natural signals and images tends have most its energy concentrated small fraction coefficients.This sparse representation property key good performance wavelets applications such data compression denoising.For example,...
This basic mechanistic study examined the changes in brain activation and resting-state connectivity after 8 weeks of CBT youth with migraine.Cognitive behavioral therapy (CBT) is a psychological intervention that effective reducing pain migraine patients. However, neural mechanisms underlying adolescents are not yet known.Eighteen (15 females, age 15.1 ± 2.1 years [mean SD]) completed weekly sessions. Before first final session, participants underwent structural blood-oxygen-level-dependent...
Purpose To develop an ultrafast T 1 mapping method for high‐resolution, volumetric measurements in the abdomen. Methods The Look‐Locker was combined with a stack‐of‐spirals acquisition accelerated using three‐dimensional (3D) through‐time spiral GRAPPA reconstruction fast data acquisition. A segmented k‐space scheme proposed and time delay between segments recovery of longitudinal magnetization optimized Bloch equation simulations. accuracy this validated phantom experiment vivo were...
Objectives The goal of this study was to develop free-breathing high–spatiotemporal resolution dynamic contrast-enhanced liver magnetic resonance imaging using non-Cartesian parallel acceleration, and quantitative perfusion mapping. Materials Methods This approved by the local institutional review board written informed consent obtained from all participants. Ten healthy subjects 5 patients were scanned on a Siemens 3-T Skyra scanner. A stack-of-spirals trajectory undersampled in-plane with...
Background Children with type 1 diabetes demonstrate worse cognitive performance compared their peers. Little is known regarding the and behavioral in obese adolescents 2 diabetes. Methods Cross sectional evaluation of 20 healthy was performed Cincinnati, Ohio. Cognitive tests that included measures processing speed, working memory, verbal semantic fluency parent reports executive function problem behavior were compared. Academic achievement relationship between cognitive/behavioral scores...
Abstract Cognitive behavioral therapy (CBT) is a psychological intervention that involves development of coping strategies to reduce the experience pain. Although CBT promising headache days in patients with migraine, it may not be effective for all patients. Thus, there need identify markers could predict which will respond CBT. We aimed determine whether baseline brain function and amygdalar connectivity, assessed by functional magnetic resonance imaging, or pain modulation capacities,...
Abstract A fast, two‐coil, pseudo‐continuous labeling scheme is presented. This new permits the collection of a multislice subtraction pair in <3 s, depending on subject's arterial transit times. The method consists acquiring both control and tag images immediately after period that matches time. theoretical basis technique, simulations signal during changes time perfusion are Experimental data from functional imaging experiments were collected to demonstrate technique its...
Abstract Contrast‐enhanced magnetic resonance angiography is challenging due to the need for both high spatial and temporal resolution. A multishot trajectory composed of pseudo‐random rotations a single multiecho radial readout was developed. The designed give incoherent aliasing artifacts relatively uniform distribution projections over all time scales. field map (computed from same data set) used avoid signal dropout in regions substantial inhomogeneity. compressed sensing reconstruction...
Purpose To achieve high temporal and spatial resolution for contrast‐enhanced time‐resolved MR angiography exams (trMRAs), fast imaging techniques such as non‐Cartesian parallel must be used. In this study, the three‐dimensional (3D) through‐time radial generalized autocalibrating partially acquisition (GRAPPA) method is used to reconstruct highly accelerated stack‐of‐stars data renal MRAs. Materials Methods Through‐time GRAPPA has been recently introduced a weight calibration, similar...
Abstract A new approach to modeling the signal observed in arterial spin labeling (ASL) experiments during changing perfusion conditions is presented this article. The model uses numerical methods extend first‐order kinetic principles include changes arrival time of tag that occur neuronal activation. Estimation function from ASL using also demonstrated. estimation algorithm a roughness penalty as well prior information. demonstrated simulations and human experiments. here particularly...
This case-control study examines if measures of subjective and objective (actigraphic) sleep difficulties mediate alterations in amygdalar connectivity adolescents with migraine compared to healthy adolescents.Adolescents have different functional the amygdala individuals without migraine. Sleep is often disturbed migraine, could contribute connectivity.Twenty 20 controls were recruited from Cincinnati Children's Hospital. Participants completed surveys about their headaches overall quality,...
The cerebral vasculature may be susceptible to the adverse effects of type 2 diabetes. In this pilot study, we compared blood flow (CBF) in youth with diabetes obese, euglycemic controls, and explored association between CBF a non-invasive measure atherosclerosis, carotid intima-medial thickness (IMT).Global regional were (mean age 16.7 ± 2.0 years, n = 20) age, race, sex similar obese without (17.4 1.9 19) using arterial spin labeling magnetic resonance imaging. Mean values groups....
Pediatric functional abdominal pain disorders (FAPD) are highly prevalent, difficult to diagnose, and challenging treat. The brain systems supporting FAPD remain poorly understood. This investigation examined the neuromechanisms of during a well-tolerated visceral induction task, water load symptom provocation task (WL-SPT). Youth between ages 11 17 years participated. Functional connectivity (FC) was through blood oxygenation level-dependent effect using left right amygdala (AMY) as seed...
Dynamic binary instrumentation for performance analysis on new, large scale architectures such as the IBM Blue Gene/L system (BG/L) poses new challenges. Their scale---with potentially hundreds of thousands compute nodes---requires more scalable mechanisms to deploy and organize collect resulting data gathered by inserted probes. Further, many these machines don't support full operating systems nodes; rather, they rely light-weight custom kernels that do not daemon-based implementations.We...
Abstract The optimal use of turbo continuous arterial spin labeling (Turbo‐CASL) for functional imaging in the presence activation‐induced transit time (TT) changes was investigated. Functional a bilateral finger‐tapping task showed improved sensitivity Turbo‐CASL as compared to traditional CASL techniques four six subjects when scanned at an appropriate repetition (TR). Both experimental and simulation results suggest that with Turbo‐CASL, pulse TR should be set value is 100–200 ms less...
Abstract A saturation‐based approach is proposed to image the arterial blood flow signal with temporal resolution of 1 2 s and in‐plane spatial a few millimeters. Using saturation suppress undesired background stationary allows water that enters slice be imaged at some specified later time. Since protons are being not restricted intravascular space, this technique also sensitive tissue perfusion contributions. The uptake characteristics method were used study different contributions as...