A5081458574- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Prenatal Substance Exposure Effects
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Congenital Diaphragmatic Hernia Studies
- Child Abuse and Related Trauma
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
- Traumatic Ocular and Foreign Body Injuries
- Migraine and Headache Studies
- Obstructive Sleep Apnea Research
- Neurological disorders and treatments
- Soft tissue tumor case studies
- Spinal Hematomas and Complications
- Heart Rate Variability and Autonomic Control
- Genetic Syndromes and Imprinting
- Ocular Diseases and Behçet’s Syndrome
Indiana University
2020-2025
Riley Hospital for Children
2017-2025
Indiana University Health
2018-2025
Indiana University School of Medicine
2018-2024
Indianapolis Zoo
2024
Indiana University – Purdue University Indianapolis
2017-2024
Indiana University Bloomington
2024
Cincinnati Children's Hospital Medical Center
2014-2021
University School
2020
New York Proton Center
2020
This basic mechanistic study examined the changes in brain activation and resting-state connectivity after 8 weeks of CBT youth with migraine.Cognitive behavioral therapy (CBT) is a psychological intervention that effective reducing pain migraine patients. However, neural mechanisms underlying adolescents are not yet known.Eighteen (15 females, age 15.1 ± 2.1 years [mean SD]) completed weekly sessions. Before first final session, participants underwent structural blood-oxygen-level-dependent...
Inherited glycosylphosphatidylinositol deficiency disorders (IGDs) are a group of rare multisystem arising from pathogenic variants in anchor pathway (GPI-AP) genes. Despite associating 24 at least 31 GPI-AP genes with human neurogenetic disease, prior reports limited to single without consideration the as whole and natural history data. In this multinational retrospective observational study, we systematically analyse molecular spectrum, phenotypic characteristics 83 individuals 75 unique...
Abusive head trauma (AHT) in children has recently been associated with findings on cervical spine MRI.
Background: Brain magnetic resonance imaging (MRI) is an important diagnostic tool for infants with possible brain abnormalities. While sedation may be necessary high quality images, it carries risks of complications. The rate MRI procedure varies widely, ranging from 0% to 100%, influenced by infant characteristics and institutional practices, increasing focus on non-sedated or minimally sedated approaches reduce risks. Purpose: We studied utilization in undergoing scanning before after...
Frontal Occipital and Temporal Horn Ratios: Comparison Validation of Head Ultrasound-Derived Indexes With MRI Ventricular Volumes in Infantile VentriculomegalyRupa Radhakrishnan1,2, Brandon Patrick Brown1,2, Stephen F. Kralik3, Danielle Bain2, Scott Persohn2, Paul R. Territo2, Andrew Jea4, Boaz Karmazyn1,2, Audio Available | Share
Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging infancy has the potential to identify early developmental alterations that may help predict behavioral these children. In this study, using resting-state functional MRI infancy, we aim differences global network connectivity infants compared healthy control infants. prospective recruited 23 29 naïve All subjects underwent before 3 months...
Purpose: The purpose of this study was to investigate the effect an intensive 8-day Samyama meditation program on brain functional connectivity using resting-state MRI (rs-fMRI). Methods: Thirteen participants (meditators) and 4 controls underwent fMRI scans before after residential program. Subjects with a blood oxygen level dependent (BOLD) contrast at rest during focused breathing. Changes in network were evaluated. In addition, validated psychological metrics correlated changes...
Tuberous sclerosis (TS), also known as Bourneville disease or Bourneville-Pringle disease, is an autosomal dominant genetic disorder classically characterized by the presence of hamartomatous growths in multiple organs. TS and tuberous complex (TSC) are different terms for same condition. Both describe clinical changes due to mutations involving either two genes named TSC1 TSC2, which regulate cell growth. The diagnosis TSC established using diagnostic criteria based on imaging findings....
Abstract Cognitive behavioral therapy (CBT) is a psychological intervention that involves development of coping strategies to reduce the experience pain. Although CBT promising headache days in patients with migraine, it may not be effective for all patients. Thus, there need identify markers could predict which will respond CBT. We aimed determine whether baseline brain function and amygdalar connectivity, assessed by functional magnetic resonance imaging, or pain modulation capacities,...
Neonatal opioid withdrawal syndrome (NOWS), arises due to increased use during pregnancy. Cytochrome P450 (CYP) enzymes play a pivotal role in metabolizing wide range of substances the human body, including opioids, other drugs, toxins, and endogenous compounds. The association between CYP gene methylation effects is unexplored it could offer promising insights.
Abstract There has been an increase in the number of women using marijuana whilst pregnant. Previous studies have shown that children with prenatal exposure developmental deficits memory and decreased attentiveness. In this study, we assess whether is associated alterations brain regional morphometry functional structural connectivity adolescents. We downloaded behavioural scores subject image files from Adolescent Brain Cognitive DevelopmentSM Study. A total 178 anatomical diffusion...
<h3>BACKGROUND AND PURPOSE:</h3> Infants with congenital diaphragmatic hernia are reported to have evidence of brain MR imaging abnormalities. Our study aimed identify perinatal clinical factors in infants that associated injury on performed before hospital discharge. <h3>MATERIALS METHODS:</h3> MRIs discharge were scored for by 2 pediatric neuroradiologists. Perinatal variables and from the neonatal intensive care unit stay analyzed potential associations findings. <h3>RESULTS:</h3>...
Hypoxic-ischaemic encephalopathy (HIE) affects 2-4/1000 live term births. Treatment with therapeutic hypothermia (TH) improves the long-term neurodevelopmental outcome of neonates moderate to severe HIE. However, early prediction still remains challenging, and no reliable easily obtainable biomarker has been identified date. Neonates HIE display impaired thermoregulation, resulting in spontaneous hypothermia. The degree cooling required achieve TH may therefore act as a injury severity....