A5013342505- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Spinal Dysraphism and Malformations
- Congenital Anomalies and Fetal Surgery
- Cerebrospinal fluid and hydrocephalus
- Teratomas and Epidermoid Cysts
- Tumors and Oncological Cases
- Prenatal Substance Exposure Effects
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Urological Disorders and Treatments
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Advanced Neuroimaging Techniques and Applications
- Tracheal and airway disorders
- Cerebral Palsy and Movement Disorders
- Cleft Lip and Palate Research
- Atomic and Subatomic Physics Research
- Neuroscience of respiration and sleep
- Connective tissue disorders research
Cincinnati Children's Hospital Medical Center
2016-2025
Predict (France)
2025
University of Cincinnati
2006-2024
University of Cincinnati Medical Center
2011-2024
Bellevue Hospital Center
2024
Imaging Center
2023
Laboratoire d’Imagerie Biomédicale
2021
Hudson Institute
2018-2020
John Wiley & Sons (United Kingdom)
2018-2020
American Institute of Ultrasound in Medicine
2018
Abstract Magnetic resonance imaging offers unrivaled visualization of the fetal brain, forming basis for establishing age-specific morphologic milestones. However, gauging age-appropriate neural development remains a difficult task due to constantly changing appearance variable image quality, and frequent motion artifacts. Here we present an end-to-end, attention-guided deep learning model that predicts gestational age with R 2 score 0.945, mean absolute error 6.7 days, concordance...
Abstract Prenatal tobacco smoke exposure (TSE) and prematurity are independent risk factors for abnormal neurodevelopment. The objectives were to compare differences in Bayley-III cognitive, language, motor scores at 2 years corrected age (CA) 395 infants born very preterm (≤ 32 weeks gestation) with without prenatal TSE. We performed multivariable linear regression analyses examine associations between TSE neurodevelopmental outcomes a mediation analysis estimate direct effects of on...
The objective of our study was to develop a small 1.5-T MRI system for neonatal imaging that can be installed in the ICU (NICU) and evaluate its performance 15 neonates.A MR designed orthopedic use adapted imaging. Modifications included raising leveling magnet, construction patient table, integration electronics from high-performance adult-sized scanner. used perform examinations brain, abdomen, chest medically stable neonates using standard clinical protocols. scanning time limited 60...
<h3>BACKGROUND AND PURPOSE:</h3> As the practice of in utero repair myelomeningoceles becomes more prevalent, knowledge expected MR imaging findings has become increasingly important. Our aim was to examine neuroimaging with a focus on hindbrain herniation and ventricular size fetuses open spinal dysraphism compare them postnatal features groups undergoing prenatal-versus-postnatal repair. <h3>MATERIALS METHODS:</h3> Single-center retrospective analysis performed MRIs from January 2004...
Primary microcephaly is a congenital brain malformation characterized by head circumference less than three standard deviations below the mean for age and sex results in moderate to severe mental deficiencies decreased lifespan. We recently studied two children with primary an otherwise unaffected family. Exome sequencing identified autosomal recessive mutation leading amino acid substitution WD40 domain of highly conserved Coatomer Protein Complex, Subunit Beta 2 (COPB2). To study role...
Importance Providing assisted ventilation during delayed umbilical cord clamping may improve outcomes for extremely preterm infants. Objective To determine whether in infants (23 0/7 to 28 6/7 weeks’ gestational age [GA]) followed by reduces intraventricular hemorrhage (IVH) or early death. Design, Setting, and Participants This phase 3, 1:1, parallel-stratified randomized clinical trial conducted at 12 perinatal centers across the US Canada from September 2, 2016, through February 21, 2023,...
Objective: To define the MRI findings of congenital high airway obstruction sequence (CHAOS) in a series fetuses.Materials and Methods: Prenatal fetal MR images were reviewed seven fetuses with CHAOS at 21 to 27 weeks gestation.The reviewed.The parameters evaluated included appearance lungs diaphragm, presence or absence hydrops, amount amniotic fluid, appearance, predicted level obstruction, any additional suspected genetic syndromes.Results: All viewed (7 7) demonstrated following...
ABSTRACT Objective The purpose of this study was to describe the relationship between intracranial and extracranial anomalies neurodevelopmental outcome for fetuses diagnosed with a posterior fossa anomaly (PFA) on fetal MRI. Methods Cases Dandy–Walker malformation, vermian hypogenesis/hypoplasia, mega cisterna magna (MCM) were identified through Fetal Care Center Cincinnati January 2004 December 2010. Parental interview retrospective chart review used assess outcome. Results Posterior in 59...
<h3>SUMMARY:</h3> Previous studies have not found structural injury or brain malformations in infants and children with prenatal opioid exposure. As part of an ongoing study evaluating neuroimaging exposure, we reviewed MR imaging 20 term exposure controls at 4–8 weeks age. We that 8 the opioid-exposed had punctate white matter lesions signal abnormality on imaging, 2 a septopreoptic fusion anomaly. No malformations. Our findings underscore importance clinical neurodevelopmental follow-up...
The aim of this study was to evaluate fetal lung growth rate for isolated left-sided congenital diaphragmatic hernia (CDH) using serial magnetic resonance imaging (MRI)-based volumetric measures.Early and late gestational (22-30 >30 weeks' gestation) volumetry obtained by MRI in 47 cases CDH. At both these time points, volume indices, including total (TLV), observed expected TLV (o/e TLV), percentage predicted (PPLV) as well their change rates (Δ) relative Δ during gestation were calculated...