A5058043675- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Global Maternal and Child Health
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Reproductive Health and Contraception
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Nutrition and Health
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Breastfeeding Practices and Influences
- Congenital Anomalies and Fetal Surgery
- COVID-19 Impact on Reproduction
- Child and Adolescent Health
- Congenital Diaphragmatic Hernia Studies
- Health disparities and outcomes
- Infant Development and Preterm Care
- Reproductive System and Pregnancy
- Fatty Acid Research and Health
University of Cincinnati Medical Center
2016-2025
University of Kentucky
2005-2025
Sabin Vaccine Institute
2011-2025
Cincinnati Children's Hospital Medical Center
2015-2024
University of Cincinnati
2015-2024
Community Link
2022-2024
Christ Hospital
2023-2024
Cedars-Sinai Smidt Heart Institute
2023
Good Samaritan Regional Medical Center
2022
Good Samaritan Hospital
2022
Abstract Objective Preterm birth is the leading cause of perinatal morbidity and mortality worldwide. Treatment preterm labor with tocolysis has not been successful in improving infant outcome. The administration progesterone related compounds proposed as a strategy to prevent birth. objective this trial was determine whether prophylactic vaginal reduces risk women history spontaneous Methods This randomized, double‐blind, placebo‐ controlled, multinational enrolled randomized 659 pregnant...
This study compared breastfeeding initiation following repeat cesarean delivery, successful vaginal birth after (VBAC), and unsuccessful trial of labor.We performed a population-based retrospective cohort Ohio births (2006-2007) with previous delivery. The primary outcomes were rates among women Breastfeeding three different delivery types: VBAC, labor. Sociodemographic factors, medical risk pregnancy-related factors also to assess influence on rates.Women delivered by VBAC 47% more likely...
Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm a disorder profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence physiological mechanisms between and model organisms typically studied. Because relatively large human head size narrow canal cross-sectional area compared other primates, we hypothesized that genes involved would display accelerated evolution along...
Objective To test the hypothesis that exposure to fine particulate air pollution (PM2.5) is associated with stillbirth. Study Design Geo-spatial population-based cohort study using Ohio birth records (2006-2010) and local measures of PM2.5, recorded by EPA (2005-2010) via 57 monitoring stations across Ohio. Geographic coordinates mother's residence for each were linked nearest PM2.5 station monthly averages calculated. The association between stillbirth increased levels was estimated,...
Test the hypothesis that exposure to fine particulate matter in air (PM2.5) is associated with increased risk of preterm birth (PTB). Geo-spatial population-based cohort study using live records from Ohio (2007–2010) linked average daily measures PM2.5, recorded by 57 EPA network monitoring stations across state. Geographic coordinates home residence for births were nearest station ArcGIS. Association between PTB and high PM2.5 levels (above annual standard 15 μg/m3) was estimated GEE,...
Several meta analyses have concluded n-3 fatty acids, including docosahexaenoic acid (DHA), reduce early preterm birth (EPB, < 34 weeks), however, the amount of DHA required is unclear. We hypothesized that 1000 mg per day would be superior to 200 mg, in most prenatal supplements.This randomised, multicentre, double-blind, adaptive-design, superiority trial was conducted three USA medical centres. Women with singleton pregnancies and 12 20 weeks gestation were eligible. randomization...
The immune response to COVID-19 booster vaccinations during pregnancy for mothers and their newborns the functional of vaccine-induced antibodies against Omicron variants are not well characterized. We conducted a prospective, multicenter cohort study participants vaccinated with primary or mRNA vaccines from July 2021 January 2022 at 9 academic sites. determined SARS-CoV-2 binding live virus pseudovirus neutralizing antibody (nAb) titers pre- post-vaccination, delivery both maternal infant...
BACKGROUND AND OBJECTIVES Maternal vaccination may prevent infant coronavirus disease 2019 (COVID-19). We aimed to quantify protection against infection from maternally derived vaccine-induced antibodies in the first 6 months of an infant’s life. METHODS Infants born mothers vaccinated during pregnancy with 2 or 3 doses a messenger RNA COVID-19 vaccine (nonboosted boosted, respectively) had full-length spike (Spike) immunoglobulin G (IgG), pseudovirus 614D, and live virus D614G, omicron BA.1...
In Brief OBJECTIVE: To investigate whether short or long interpregnancy interval is associated with uterine rupture and other major maternal morbidities in women who attempt vaginal birth after cesarean delivery (VBAC). METHODS: We performed a secondary analysis of U.S. multi-center, record-based, retrospective cohort study 13,331 pregnant women, identified by validated International Classification Disease, 9th Revision, code search, at least one prior delivery, attempted VBAC between 1995...
Preterm birth is a complex disease with etiologic influences from variety of social, environmental, hormonal, genetic, and other factors. The purpose this study was to utilize large population-based registry estimate the independent effect county-level poverty on preterm risk. To accomplish this, we used multilevel logistic regression approach account for multiple co-existent individual-level variables rate.Population-based utilizing Missouri's certificate database (1989-1997). We conducted...
In Brief OBJECTIVE: To assess the association of reported smoking cessation at various time points during pregnancy with fetal growth restriction. METHODS: This was a population-based retrospective cohort study singleton nonanomalous live births using Ohio birth certificates, 2006–2012. Outcomes women who only in 3 months before conception and through first, second, or third trimester were compared referent group nonsmokers. Multivariate logistic regression assessed between times restriction...
Neutrophil infiltration of the chorioamnion-decidua tissue at maternal-fetal interface (chorioamnionitis) is a leading cause prematurity, fetal inflammation, and perinatal mortality. We induced chorioamnionitis in preterm rhesus macaques by intraamniotic injection LPS. Here, we show that, during chorioamnionitis, amnion upregulated phospho-IRAK1–expressed neutrophil chemoattractants CXCL8 CSF3 an IL-1–dependent manner. IL-1R blockade decreased chorio-decidua accumulation, activation, IL-6...
Polybrominated diphenyl ethers (PBDEs) were widely used as flame retardants in the past three decades. These compounds are lipophilic and easily cross placenta from pregnant woman to fetus. It is not clear whether hydroxylated PBDEs (OH-PBDEs), with greater hydrophilicity, have different concentrations maternal cord serum samples. We analyzed (BDE-28, -47, -99, -100, -153, -154, -209) OH-PBDEs (6-OH-BDE-47, 5-OH-BDE-47, 4'-OH-BDE-49, 5'-OH-BDE-99) 20 pairs of samples collected Cincinnati, OH...
<h3>Importance</h3> The rate of obesity among US women has been increasing, and is associated with increased risk surgical site infection (SSI) following cesarean delivery. optimal perioperative antibiotic prophylactic regimen in this high-risk population undergoing delivery unknown. <h3>Objective</h3> To determine rates SSI obese who receive oral cephalexin metronidazole vs placebo for 48 hours <h3>Design, Setting, Participants</h3> Randomized, double-blind clinical trial comparing the...
To develop and validate a predictive risk calculator for cesarean delivery among women undergoing induction of labor.We performed population-based cohort study all who had singleton live births after labor from 32 0/7 to 42 6/7 weeks gestation in the United States 2012 2016. The primary objective was build model estimating probability using antenatal factors obtained de-identified U.S. live-birth records. Multivariable logistic regression estimated association these on delivery. K-fold cross...
Abstract Objectives To determine whether progesterone supplementation alters cervical shortening in women at increased risk for preterm birth. Methods We performed a planned secondary analysis from large, multinational birth prevention trial of daily intravaginal gel, 90 mg, com‐ pared with placebo history spontaneous or premature shortening. Transvaginal length measurements were obtained all randomized patients baseline (18 + 0 to 22 6 weeks' gestation) and 28 gestation. For this analysis,...
<i>Objective:</i> While multiple lines of evidence suggest the importance genetic contributors to risk preterm birth, nature component has not been identified. We perform segregation analyses identify best fitting model for gestational age, a quantitative proxy birth. <i>Methods:</i> Because either mother or infant can be considered proband from delivery and there is that factors in one both may influence trait, we performed analysis age attributed (infant’s age), (by...