A5002182278- Infant Nutrition and Health
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Genetics and Neurodevelopmental Disorders
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Metabolism and Genetic Disorders
- Genetic Associations and Epidemiology
- Cardiovascular Issues in Pregnancy
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Bone health and treatments
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Connective tissue disorders research
- Congenital Anomalies and Fetal Surgery
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Congenital Heart Disease Studies
- Advanced Causal Inference Techniques
University of California, Los Angeles
2019-2023
Vanderbilt University
2005-2016
Center for Human Genetics
2011-2013
Vanderbilt University Medical Center
2005-2011
Monroe Carell Jr. Children's Hospital
2011
Columbia University
2004-2008
Philadelphia University
2008
Hôpital Antoine-Béclère
2005
UW Health University Hospital
2005
Université Paris-Sud
2005
The aim of the present study was to determine if patients with both pulmonary arterial hypertension (PAH), due vascular obstructive disease, and congenital heart defects (CHD), have mutations in gene encoding bone morphogenetic protein receptor (BMPR)-2. BMPR2 screened two cohorts: 40 adults 66 children PAH/CHD. CHDs were patent ductus arteriosus, atrial ventricular septal defects, partial anomalous venous return, transposition great arteries, atrioventicular canal, rare lesions...
Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm a disorder profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence physiological mechanisms between and model organisms typically studied. Because relatively large human head size narrow canal cross-sectional area compared other primates, we hypothesized that genes involved would display accelerated evolution along...
Rationale: Serotonin is a pulmonary vasoconstrictor and smooth muscle cell mitogen. The serotonin transporter (SERT) abundant in vascular muscle. Compared with the short (S) allele, long (L) SERT promoter allele associated increased transcription more severe hypertension cohort of patients chronic obstructive disease, was prevalent idiopathic arterial (IPAH), compared control subjects.Objective: We hypothesized that L would associate an earlier age at diagnosis and/or shorter survival...
The onset of birth in humans, like other apes, differs from non-primate mammals its endocrine physiology. We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved human preterm birth, an area global health significance.We performed a comparative genomics screen highly conserved noncoding elements identified PLA2G4C, phospholipase A isoform prostaglandin biosynthesis as accelerated. To examine whether this demonstrating was associated...
Abstract Risky decision-making is a common, heritable endophenotype seen across many psychiatric disorders. Its underlying genetic architecture incompletely explored. We examined behavior in the Balloon Analogue Risk Task (BART), which tests risky decision-making, two independent samples of European ancestry. One sample ( n = 1138) comprised healthy participants and some patients (53 schizophrenia, 42 bipolar disorder, 47 ADHD); other 911) excluded for recent treatment various disorders but...
Abstract Risky decision-making is a common, heritable endophenotype seen across many psychiatric disorders. Its underlying genetic architecture incompletely explored. We examined behavior in the Balloon Analogue Risk Task (BART), which tests risky decision-making, two independent samples of European ancestry. One sample (n=1138) comprised healthy participants and some patients (53 schizophrenia, 42 bipolar disorder, 47 ADHD); other (n=911) excluded for recent treatment various disorders but...