A5033727516- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Ethics in Clinical Research
- Breast Cancer Treatment Studies
- Meta-analysis and systematic reviews
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Statistical Methods in Clinical Trials
- Advanced Breast Cancer Therapies
- Fatty Acid Research and Health
- Colorectal Cancer Screening and Detection
- Health disparities and outcomes
- Food Security and Health in Diverse Populations
- Health and Medical Research Impacts
- Birth, Development, and Health
- Biomedical Text Mining and Ontologies
- COVID-19 and healthcare impacts
- Nutritional Studies and Diet
- SARS-CoV-2 and COVID-19 Research
- Delphi Technique in Research
- Chronic Disease Management Strategies
- Infant Nutrition and Health
- Geriatric Care and Nursing Homes
- Intracerebral and Subarachnoid Hemorrhage Research
- Psychometric Methodologies and Testing
The University of Kansas Cancer Center
2018-2025
University of Kansas Medical Center
2016-2025
Biostats (United States)
2024
University of Kansas
2019-2023
University of Arizona
2023
Abstract Purpose: Addition of carboplatin (Cb) to anthracycline chemotherapy improves pathologic complete response (pCR), and plus taxane regimens also yield encouraging pCR rates in triple-negative breast cancer (TNBC). Aim the NeoSTOP multisite randomized phase II trial was assess efficacy anthracycline-free anthracycline-containing neoadjuvant regimens. Patients Methods: aged ≥18 years with stage I–III TNBC were (1:1) receive either paclitaxel (P) weekly × 12 AUC6 every 21 days 4 followed...
Several meta analyses have concluded n-3 fatty acids, including docosahexaenoic acid (DHA), reduce early preterm birth (EPB, < 34 weeks), however, the amount of DHA required is unclear. We hypothesized that 1000 mg per day would be superior to 200 mg, in most prenatal supplements.This randomised, multicentre, double-blind, adaptive-design, superiority trial was conducted three USA medical centres. Women with singleton pregnancies and 12 20 weeks gestation were eligible. randomization...
<h3>Importance</h3> Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications been tried for pain reduction CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication CSPN. <h3>Objective</h3> To determine which (pregabalin, duloxetine,...
The National Clinical Trials Network program conducts phase 2 or 3 treatment trials across all Cancer Institute's designated cancer centers. Participant accrual these clinical is a critical factor in deciding their success. centers that cater to rural populations, such as University of Kansas Center, have an additional responsibility ensure residents access and are well represented studies.
The durability of the antibody response to COVID-19 vaccines in patients with cancer undergoing treatment or who received a stem cell transplant is unknown and may be associated infection outcomes.To evaluate anti-SARS-CoV-2 spike protein receptor binding domain (anti-RBD) neutralizing (nAb) responses longitudinally over 6 months (SCT).In this prospective, observational, longitudinal cross-sectional study 453 an SCT at University Kansas Cancer Center City, blood samples were obtained before...
This research study aimed to evaluate the financial burden among older cancer patients and its corresponding risk factors. Factors such as increasing treatment costs work limitations often lead bankruptcy poor quality of life. These consequences, in turn, can cause higher mortality rates these patients.This retrospective cohort utilized data from Health Retirement Study (HRS), conducted by University Michigan (N = 18,109). Eligible participants had responses captured years 2002 2016....
BackgroundIntention-to-treat analyses do not address adherence. Per protocol treat nonadherence as a deviation and assess if the intervention is effective followed.ObjectiveTo determine rate of early preterm birth (EPTB, <34 weeks gestation) (PTB, <37 in participants who adhered to randomly assigned docosahexaenoic acid (DHA) dose 1000 mg/day.Study designEleven hundred women with singleton pregnancy were enrolled before 20-weeks' gestation, provided capsule 200 mg/day DHA two additional...
Abstract Background Cancer is a critical disease that affects person physically, mentally, socially, and in many other aspects. During the treatment stage of cancer, patients suffer from various health complexities, especially elderly people, which might result onset diseases development comorbid condition. Several studies have shown comorbidity plays crucial role cancer survival. However, there remains lack comprehensive statistical techniques at national level to assess significance...
We aimed to investigate factors associated with cytomegalovirus (CMV) viremia and CMV disease its impact on post-transplant outcomes including overall survival (OS) following allogeneic hematopoietic stem cell transplantation (Allo-SCT).
ABSTRACT Background The approval of amyloid‐targeting monoclonal antibodies has transformed Alzheimer's disease (AD) treatment, shifting the field from symptomatic management to targeting underlying pathology. These therapies require specialized care models manage selection, and monitoring eligible patients. Methods Here, we describe implementation Anti‐Amyloid Treatment Clinic (KU‐AATC) at University Kansas Health System, a dedicated clinic model designed streamline access amyloid‐clearing...
Heart failure (HF), the leading cause of morbidity and mortality in US, affects 6.6 million adults with an estimated additional 3 people by 2030. More than 50% HF patients have heart preserved left ventricular ejection fraction (HFpEF). These impaired cardiac muscle relaxation diastolic filling, which investigators associated cellular energetic impairment. Patients HFpEF experience symptoms of: (1) fatigue; (2) shortness breath; (3) swelling (edema) lower extremities. However, current...
In the last few decades, number of trials using Bayesian methods has grown rapidly. Publications prior to 1990 included only three clinical that used methods, but quickly jumped 19 in 1990s and 99 from 2000 2012. While this literature provides many examples Adaptive Designs (BAD), none papers are available walks reader through detailed process conducting a BAD. This paper fills gap by describing BAD for one comparative effectiveness trial (Patient Assisted Intervention Neuropathy: Comparison...
Anticoagulants prevent thrombosis and death in patients with atrial fibrillation venous thromboembolism (VTE) but also increase bleeding risk. The benefit/risk ratio favors anticoagulation most of these patients. However, some will have a complication, such as the common trip-and-fall brain injury elderly that results traumatic intracranial hemorrhage. Clinicians must then make difficult decision about when to restart anticoagulant. Restarting too early risks making worse. late thrombotic...
Electronic health records (EHR) represent a rich resource for conducting observational studies, supporting clinical trials, and more. However, much of the data contains unstructured text, presenting an obstacle to automated extraction. Natural language processing (NLP) can structure learn from but NLP algorithms were not designed unique characteristics EHR. Here, we propose Relevant Word Order Vectorization (RWOV) aid with structuring. RWOV is based on finding positional relationship between...
How the socioeconomic factors intersect for a particular patient can determine their susceptibility to financial toxicity, what costs they will encounter during treatment, type and quality of care, potential work impairments face. The primary goal this study was evaluate leading worsening health outcomes by cancer subtype. A logistic model predicting while assessing most influential economic constructed University Michigan Health Retirement Study. forward stepwise regression procedure...
Abstract Data used to determine patient eligibility for cancer clinical trials often come from disparate sources that are typically maintained by different groups within an institution, use differing technologies, and stored in formats. Collecting data resolving inconsistencies across increase the time it takes screen eligible patients, potentially delaying study completion. To address these challenges, Biostatistics Informatics Shared Resource at The University of Kansas Cancer Center...
Abstract Background Rural residence is commonly thought to be a risk factor for poor cancer outcomes. However, number of studies have reported seemingly conflicting information regarding outcome disparities with respect rural residence, some suggesting that the disparity not present and others providing inconsistent evidence either urban or associated poorer We suggest simple explanation these seeming contradictions: namely are related factors occur differentially at local level, such as...
The COVID-19 pandemic brought greater focus to the rural mortality penalty in U.S., which describes rate compared urban areas. Although it is widely thought that issues such as access care, age structure of population, and differences behavior are likely drivers penalty, few studies have attempted tie delayed care populations healthcare outcomes quantitatively. Therefore, critical try understand these factors enable more effective public health policy.
Background: Despite advances in the early detection and treatment of breast cancer (BC), inequity persists, BC mortality rate remains approximately 40% higher among Black African American (B/AA) women compared to White (W) women. Methods: In response The University Kansas Cancer Center's Catchment Area Steering Committee identified priorities, Breast Health Equity Task Force (BCHETF) leveraged data-driven insights develop targeted interventions that promote prevention B/AA Results: By...
New software that performs Classical and Bayesian Instrument Development (CBID) is reported seamlessly integrates expert (content validity) participant data (construct to produce entire reliability estimates with smaller sample requirements. The free CBID can be accessed through a website used by clinical investigators in new instrument development. Demonstrations are presented of the three approaches using software: (a) traditional confirmatory factor analysis (CFA), (b) CFA flat...