A5065276712- Dementia and Cognitive Impairment Research
- Radiology practices and education
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Obesity, Physical Activity, Diet
- Breast Cancer Treatment Studies
- Innovations in Medical Education
- Breast Lesions and Carcinomas
- Amyotrophic Lateral Sclerosis Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Diversity and Career in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Workplace Health and Well-being
- Health, Environment, Cognitive Aging
- Sleep and related disorders
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Advances in Oncology and Radiotherapy
- Surgical Simulation and Training
- Medication Adherence and Compliance
- Genetics, Aging, and Longevity in Model Organisms
- Salivary Gland Tumors Diagnosis and Treatment
- Health and Medical Research Impacts
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Risk Factors
University of Kansas Medical Center
2013-2025
University of Kansas
2013-2024
The University of Kansas Health System
2019
University of Pennsylvania
2018
Penn Center for AIDS Research
2016
Background Our goal was to investigate the role of physical exercise protect brain health as we age, including potential mitigate Alzheimer’s-related pathology. We assessed effect 52 weeks a supervised aerobic program on amyloid accumulation, cognitive performance, and volume in cognitively normal older adults with elevated sub-threshold levels cerebral measured by PET imaging. Methods findings This 52-week randomized controlled trial compared effects 150 minutes per week vs. education...
Face-to-face (FTF) weight management is costly and presents barriers for individuals seeking treatment; thus, alternate delivery systems are needed. The objective of this study was to compare delivered by FTF clinic or group conference calls (phone).
Establishing reliable methods for interpreting elevated cerebral amyloid-β plaque on PET scans is increasingly important radiologists, as availability of imaging in clinical practice increases. We examined a 3-step method to detect cognitively normal older adults, focusing the additive value quantitative information during scan interpretation process.Fifty-five F-florbetapir were evaluated by 3 experienced raters. Scans first visually interpreted having "elevated" or "nonelevated" burden...
Both the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) neuroimaging biomarkers of AD. No studies investigated relationship TOMM40'523-APOE on structural complexity brain in AD individuals. We quantified morphology multiple cortical attributes individuals mild cognitive impairment (MCI) AD, then tested whether or poly-T genotypes were related to morphological cognitively unimpaired (CU) MCI/AD identified several AD-specific phenotypes...
Introduction: In acute stroke patients who receive revascularization with endovascular thrombectomy (EVT) alone vs intravenous thrombolysis (IVT) followed by EVT, combination treatment has shown improved outcomes measured the modified Rankin Scale (mRS). However, neurocognitive beyond functional disability have not been sufficiently assessed. Hypothesis: We hypothesize that will be IVT + EVT compared to alone. Methods: This prospective ongoing longitudinal study included a first-ever...
Abstract Most adults with Down syndrome (DS) will develop pathology associated Alzheimer's disease (AD). By age 65, the cumulative incidence of dementia exceeds 90%. The available data from trials in typically developed suggest potential for intentional weight loss and changes dietary intake to prevent or delay development AD. However, AD DS has not been previously examined. In this article, we describe methods rationale a randomized trial that evaluate impact on factors may including...
In the last few decades, number of trials using Bayesian methods has grown rapidly. Publications prior to 1990 included only three clinical that used methods, but quickly jumped 19 in 1990s and 99 from 2000 2012. While this literature provides many examples Adaptive Designs (BAD), none papers are available walks reader through detailed process conducting a BAD. This paper fills gap by describing BAD for one comparative effectiveness trial (Patient Assisted Intervention Neuropathy: Comparison...
Patients with amyotrophic lateral sclerosis (ALS) are susceptible to malnutrition, appropriate management of nutritional interventions an active area investigation. We sought determine the impact gastrostomy tube placement in ALS patients, exploring correlation between forced vital capacity (FVC), and perioperative complications.
Although women and men in jails bear a burden of health problems, little is known about factors associated with their care use. We conducted cross-sectional survey preincarceration use 596 jail inmates. Descriptive statistics correlates participants' were assessed. A year before incarceration, 54% participants used an emergency room, 24% hospitalized, 39% primary care. Correlates included gender, insurance status, drug dependence. For without mental was living neighborhoods where higher...
About 50% of all hospitalized fragility fracture cases in older Americans are hip fractures. Approximately 3/4 fracture-related costs the USA attributable to fractures, and these mostly covered by Medicare. Hip patients with dementia, including Alzheimer's disease, have worse health outcomes longer hospital length stay (LOS) charges. LOS charges for dementia usually higher than those without dementia. Research describing acute care fractures has focused on trauma a known pre-admission...
Amyotrophic lateral sclerosis (ALS) patients lack effective treatments to maintain motor and neuromuscular function. This study aimed evaluate the effect of a home-based exercise program on muscle strength, ALS scores, transcriptome in patients, Clinical Trials.gov #NCT03201991 (28/06/2017). An open-label, non-randomized pilot clinical trial was conducted seven individuals with early-stage ALS. Participants were given 3 months resistance focusing quadriceps muscles. The strength exercised...
Objective: To examine the symptoms experienced and change in driving habits individuals with concussion.Materials methods: A survey was created by a team of rehabilitation professionals who see persons concussion their clinics. The captured demographics, mechanism injury, date during driving, if drivers felt safe when changes since concussion. Non-parametric tests were used to compare across three groups which based on time injury.Results: Of 140 participants, 74% (104/140) had resumed after...
IntroductionAlthough oral P2Y12 inhibitors (P2Y12-Is) are one of the most commonly prescribed medication classes in patients with end stage kidney disease on dialysis (ESKD), scarce data exist regarding their benefits and risks.MethodsWe compared effectiveness safety clopidogrel, prasugrel, ticagrelor a longitudinal study using United States Renal Data System registry Medicare beneficiaries ESKD. Individuals who filled new P2Y12-I prescriptions between 2011 2015 were included followed until...