A5024722154- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Family and Disability Support Research
- Mosquito-borne diseases and control
- Retinopathy of Prematurity Studies
- Autism Spectrum Disorder Research
- Global Maternal and Child Health
- Cancer Research and Treatments
- Congenital Heart Disease Studies
- Bladder and Urothelial Cancer Treatments
- Context-Aware Activity Recognition Systems
- Functional Brain Connectivity Studies
- Infectious Diseases and Tuberculosis
- Advanced Neuroimaging Techniques and Applications
- Infant Health and Development
- COVID-19 epidemiological studies
- Nanoplatforms for cancer theranostics
- COVID-19 and healthcare impacts
- Gait Recognition and Analysis
- Retinal Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
Northwestern University
2019-2025
National Institute of Neurological Disorders and Stroke
2022
Health and Human Development (2HD) Research Network
2022
Comer Children's Hospital
2019-2022
University of Wisconsin–Madison
2022
University of Minnesota
2022
University of Chicago
2016-2020
University of Chicago Medical Center
2013
The Prechtl General Movement Assessment (GMA) has become a cornerstone assessment in early identification of cerebral palsy (CP), particularly during the fidgety movement period at 3–5 months age. Additionally, motor repertoire, such as antigravity movements and postural patterns, which form Motor Optimality Score (MOS), may provide insight into an infant’s later function. This study aimed to identify specific markers for ambulation, gross function (using Gross Function Classification...
<h3>Importance</h3> There is an urgent need to assess neurodevelopment in Zika virus (ZIKV)–exposed infants. <h3>Objectives</h3> To perform general movement assessment (GMA) at 9 20 weeks' postterm age and evaluate whether the findings are associated with neurodevelopmental outcomes 12 months infants prenatally exposed acute maternal illness rash Brazil during ZIKV outbreak age-matched controls. <h3>Design, Setting, Participants</h3> In this cohort study, were recruited medical institutions...
Background: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim the present study was to a novel machine-learning model, Computer-based Infant Movement Assessment (CIMA) clinically feasible CP prediction based on infant video recordings. Methods: CIMA model designed assess proportion (%) risk-related movements using time–frequency decomposition movement trajectories infant’s body parts. developed tested recordings...
Early identification of cerebral palsy (CP) is important for early intervention, yet expert-based assessments do not permit widespread use, and conventional machine learning alternatives lack validity.
Background: The general movement optimality score (GMOS) quantifies the details of movements (GMs). We recently conducted psychometric analyses GMOS and developed a revised scoresheet. Consequently, GMOS-Revised (GMOS-R) instrument necessitated validation using new percentile ranks. This study aimed to provide these ranks for GMOS-R investigate whether sex, preterm birth, or infant’s country birth residence affected distribution. Methods: applied an international sample 1983 infants (32%...
Aim To determine the relationship between Test of Infant Motor Performance ( TIMP ) at 3 months and cognitive, language, motor outcomes on Bayley Scales Toddler Development, Third Edition (Bayley‐ III 2 years age in high‐risk infants born preterm. Method One hundred six (47 females, 59 males) earlier than 31 weeks gestational were prospectively tested with 10 to 15 after term assessed again Bayley‐ corrected age. Sensitivity specificity calculated for various cut points z‐score composite...
<h3>BACKGROUND AND PURPOSE:</h3> Very preterm infants (birth weight, <1500 g) are at increased risk of cognitive and motor impairment, including cerebral palsy. These adverse neurodevelopmental outcomes associated with white matter abnormalities on MR imaging term-equivalent age. Cerebral palsy has been predicted by analysis spontaneous movements in the infant termed “General Movement Assessment.” The goal this study was to determine utility General Assessment predicting cognitive,...
Early prediction of cerebral palsy (CP) using the General Movement Assessment (GMA) during fidgety movements (FM) period has been recommended as standard care in high-risk infants. The aim this study was to determine accuracy GMA, alone or combination with neonatal imaging, predicting (CP).Infants increased risk perinatal brain injury were prospectively enrolled from 2009-2014 multi-center, observational study. FM classified by two certified GMA observers blinded clinical history. Abnormal...
The long-term neurodevelopmental effects of antenatal Zika virus (ZIKV) exposure in children without congenital syndrome (CZS) remain unclear, as few have been examined to the age school entry level. A total 51 Colombian with ZIKV CZS and 70 unexposed controls were evaluated at 4–5 years using Behavior Rating Inventory Executive Function (BRIEF), Pediatric Evaluation Disability (PEDI-CAT), Bracken School Readiness Assessment (BSRA), Movement Battery for Children (MABC). mean ages evaluation...
Easy access to precise 3D tracking of movement could benefit many aspects rehabilitation. A challenge achieving this goal is that while there are datasets and pretrained algorithms for able-bodied adults, trained on these often fail generalize clinical populations including people with disabilities, infants, neonates. Reliable analysis infants neonates important as spontaneous behavior an indicator neurological function neurodevelopmental disability, which can help guide early interventions....
Neurodevelopmental outcomes for preschool-age children in the United States with utero Zika virus (ZIKV) exposure have not yet been reported. We performed a case-control study to assess whether exposed ZIKV abnormal neurodevelopment at age 4–5 years compared unexposed controls. Thirteen ZIKV-exposed cases that did microcephaly or other specific features of congenital syndrome and 12 controls were evaluated between ages years. Child was assessed using Pediatric Evaluation Disability...
To evaluate neurodevelopmental outcomes among infants treated for retinopathy of prematurity (ROP) at the authors' institution.Before-and-after retrospective chart reviews identified 40 with laser and 46 primary intravitreal bevacizumab (IVB). Primary were death, hearing loss, bilateral visual impairment (BVI), cerebral palsy (CP); odds ratios (ORs) calculated to determine factors associated CP. Secondary mean Bayley Scales Infant Toddler Development, Third Edition (BSID-III) scores.Overall,...
Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm with normal or impaired development is unknown. However, abnormal spontaneous motor behavior 12–15 post-term age associated impairment. We imaged blood oxygen level-dependent signals term-equivalent in 62 <32 and explored whether resting state functional connectivity (rsFC) differed performances on the General Movement...
Abstract Aim To describe the development of an observational measure spontaneous independent joint motion in infants with spastic cerebral palsy (CP), Baby Observational Selective Control AppRaisal (BabyOSCAR), and to test its convergent validity reliability. Method A retrospective sample 75 (45 CP 30 without CP) at 3 months age were scored BabyOSCAR compared diagnosis CP, limbs affected, Gross Motor Function Classification level 2 years or later for using t ‐tests, Kruskal–Wallis tests,...
Abstract Aim To assess the predictive capabilities of Baby Observational Selective Control AppRaisal (BabyOSCAR) tool, administered at 3 months corrected age, in determining spastic cerebral palsy (CP) outcome, functional abilities, and body topography 2 years age or later. Method Independent joint motions were measured 10 to 16 weeks from video recordings spontaneous movement using BabyOSCAR a sample 75 infants. All included infants had known 2‐year outcomes (45 with CP 30 without CP)...
Cerebral palsy (CP), often caused by early brain injury such as perinatal stroke or hemorrhage, is the most common lifelong motor disability. Early identification of at-risk infants and timely access to rehabilitation interventions are essential for improving long-term outcomes. The General Movements Assessment (GMA), performed in first months life, has high sensitivity specificity predict CP; however, neurological correlates general movements remain unclear. This analysis aimed investigate...
Objectives: To characterize early developmental trajectories of selective motor control (SMC) in very preterm infants and examine associations with later cerebral palsy (CP) diagnosis gross function. Methods: Very (<32 weeks gestation) were recorded every 2 to 4 until 5 months post term age (PTA). SMC was scored from 352 videos (n=47 infants; 12 CP) using BabyOSCAR, a validated observational tool. Linear mixed models examined by CP Gross Motor Function Classification System (GMFCS) level....