A5088727921- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Gene expression and cancer classification
- Glaucoma and retinal disorders
- Head and Neck Cancer Studies
- Hypothalamic control of reproductive hormones
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- Congenital Heart Disease Studies
- Ecology and Vegetation Dynamics Studies
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- Photoreceptor and optogenetics research
- Advanced Proteomics Techniques and Applications
- Obesity, Physical Activity, Diet
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Plant Disease Resistance and Genetics
- Botany and Plant Ecology Studies
- Pulmonary Hypertension Research and Treatments
Children's National
2022-2025
Center for Cancer and Blood Disorders
2025
MedStar Health
2024-2025
National Hospital
2024
University of California, San Francisco
2024
Beaumont Hospital, Royal Oak
2023
Beaumont Health
2018-2022
Michigan United
2016-2019
Royal Oak Community Coalition
2019
Botsford Hospital
2019
Abstract Objectives/Hypothesis: Black patients are reported to have a higher incidence of advanced disease and increased mortality from head neck squamous cell carcinoma (HNSCC) but constitute the minority in large‐scale studies investigating effect race on outcome. This study sought determine if racial disparities exist between black white with HNSCC treated at single large institution South high proportion patients. Study Design: The authors conducted nonrandomized retrospective cohort...
Genome-wide association (GWA) studies revealed a number of single nucleotide polymorphisms (SNPs) significantly associated with type 1 diabetes (T1D). In an attempt to confirm some these candidate associations, we genotyped 2046 Caucasian patients and 2417 normal controls from the United States for SNPs in five genomic regions. While no evidence was obtained four regions (rs2929366/ NM_144715 on chromosome 3, rs9127/ Q7Z4C4 5, rs1445898/ CAPSL 5 rs2302188/ NM_033543 19), provide strong...
This trial aimed to identify the effects of providing pharmacogenomic (PGx) results and recommendations for patients with chronic pain treated in primary care practices compared standard care. An open-label, prospective, largely virtual, type-2 hybrid effectiveness randomized participants PGx or arms. Adults ≥ 3 months who were tramadol, codeine, hydrocodone enrolled. Alternative analgesics recommended CYP2D6 intermediate poor metabolizers (IM/PMs). Prescribing decisions at providers'...
BackgroundAlthough the risk of exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is higher for frontline healthcare workers, not all personnel have similar risks. Determining infection rate difficult due limits on testing and high asymptomatic individuals. Detection antibodies against SARS-CoV-2 may be useful determining prior virus assessing mitigation strategies, such as isolation, masks, other protective equipment.
Abstract Studies of genetic variation at allozyme loci, assumed to be selectively neutral, have provided valuable insights into the structure numerous populations. The degree which population reflects that quantitative traits, however, is not well resolved. Here, we compare estimates differentiation (FST) 11 populations for allozymes with those nine discrete and continuous morphological traits. Overall, lowest FST estimates, indicating relatively little differentiation. Excepting two petal...
Metastatic dissemination of primary tumors is responsible for 90% colorectal cancer (CRC) deaths. The presence positive lymph nodes, which separates stage I/II from III CRC, a particularly key factor in patient management. Here, we describe results quantitative proteomic survey to identify molecular correlates node status. Laser capture microdissection and two-dimensional difference gel electrophoresis were used establish expression profiles 980 discrete protein features 24 human CRC...
Abstract Cervical cancer originates with human papillomavirus (HPV) infection and progresses via histologically defined premalignant stages. Here we compare normal cervical epithelium patient‐matched high‐grade squamous intraepithelial lesions (HSIL) carcinoma tissue from the same patient population ( n = 10 per group). Specimens were analyzed by combined laser capture microdissection 2‐D DIGE. Significant expression changes seen 53 spots resulting in identification of 23 unique proteins at...
Abstract Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical natural populations. Theoretical studies demonstrate that polygenic characters depends heavily on the interdependence expression traits different which selection occurs, but information concerning this issue is scarce. We conducted a field experiment assess variability annual plant Nemophila menziesii five biotic regimes differing density...
Laser capture microdissection (LCM) provides the capability to isolate and analyze small numbers of cells from a specific area histologic section. LCM has particular value for analysis early stage tumors, which are often intermixed with non-tumor tissue. It previously been shown that new generation cysteine-reactive cyanine dyes can, in principle, provide increased sensitivity two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) profiling when sample quantitities limiting....
We identify noninvasive biomarkers that measure the severity of oxidative stress within retina layers in sodium iodate (SI)-atrophy vulnerable (C57BL/6 [B6]) and SI-atrophy resistant (129S6/SvEvTac [S6]) mice.At 24 hours after administering systemic SI to B6 S6 mice we measured: (1) superoxide production whole ex vivo, (2) excessive free radical vivo based on layer-specific 1/T1 values before α-lipoic acid (ALA) administration while animal was inside magnet (QUEnch-assiSTed MRI [QUEST MRI]),...
The long-term neurodevelopmental effects of antenatal Zika virus (ZIKV) exposure in children without congenital syndrome (CZS) remain unclear, as few have been examined to the age school entry level. A total 51 Colombian with ZIKV CZS and 70 unexposed controls were evaluated at 4–5 years using Behavior Rating Inventory Executive Function (BRIEF), Pediatric Evaluation Disability (PEDI-CAT), Bracken School Readiness Assessment (BSRA), Movement Battery for Children (MABC). mean ages evaluation...
Neurodevelopmental outcomes for preschool-age children in the United States with utero Zika virus (ZIKV) exposure have not yet been reported. We performed a case-control study to assess whether exposed ZIKV abnormal neurodevelopment at age 4–5 years compared unexposed controls. Thirteen ZIKV-exposed cases that did microcephaly or other specific features of congenital syndrome and 12 controls were evaluated between ages years. Child was assessed using Pediatric Evaluation Disability...
Chemical applications, with the exception of mancozeb, reduced population sizes and spread Clavibacter michiganensis subsp. among tomato seedlings in greenhouse impacted subsequent plant development yield field. While applications copper hydroxide, hydroxide/mancozeb, hydroxide/mancozeb (premixed 12 h before spraying), streptomycin, streptomycin/copper hydroxide to did not differ significantly from inoculated control, trend was for these treatments increase survival transplants field...