A5103259402- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Cervical and Thoracic Myelopathy
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Advanced Neuroimaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Immune Cell Function and Interaction
- Hedgehog Signaling Pathway Studies
- Genetic Associations and Epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac tumors and thrombi
- Thyroid Cancer Diagnosis and Treatment
- Adrenal Hormones and Disorders
- NF-κB Signaling Pathways
- Knee injuries and reconstruction techniques
- Spinal Fractures and Fixation Techniques
- Gene expression and cancer classification
Guangzhou First People's Hospital
2018-2025
Guangzhou Medical University
2018-2025
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2021-2023
Guangzhou University of Chinese Medicine
2021-2023
Moffitt Cancer Center
2007-2009
University of South Florida
2008
Augusta University
2004-2007
The lymphoid-specific phosphatase (LYP) encoded by PTPN22 is involved in preventing spontaneous T-cell activation dephosphorylating and inactivating receptor-associated Csk kinase. We have genotyped 396 type 1 diabetic patients 1,178 control subjects of Caucasian descent from north central Florida report a strong association between diabetes polymorphism (R620W) the gene. homozygous genotype for T allele encoding 620W residue associated with an increased risk developing (odds ratio [OR] =...
Purpose: A prognostic nomogram was applied to predict survival in osteosarcoma patients. Patients and methods: Data collected from 2,195 patients the Surveillance, Epidemiology, End Results (SEER) database between 1983 2014 were analyzed. Independent factors identified via univariate multivariate Cox analyses. These incorporated into a 3- 5-year overall (OS) cancer-specific (CSS) rates. Internal external data used for validation. Concordance indices (C-indices) estimate accuracy. Results:...
Few genetic mutations have been identified in pancreatic adenocarcinoma, whereas epigenetic changes that lead to gene silencing are known several genes. Because SLC5A8 is regarded as a potential tumor suppressor down-regulated by other cancers, we sought characterize promoter methylation status and its relationship expression cancer.Promoter of were evaluated cancer cell lines, tumor, adjacent nontumor tissues from patients using methylation-specific polymerase chain reaction analysis,...
The autoimmune regulator (Aire) gene plays an essential role in negative selection of T cells and deletion autoreactive the thymus. defect thymic Aire(-/-) mice was attributed to repressed expression tissue-specific Ags epithelial defective Ag presentation; however, molecular mechanism underlying these functions has been elusive. Using chromatin immunoprecipitation technique, we demonstrate here that Aire binds vivo specific DNA sequence motifs directly regulates genes important for...
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in downregulation of antigen-activated immune response and polymorphisms at the CTLA-4 gene have been shown to be associated with several autoimmune diseases including type-1 diabetes (T1D). The etiological mutation was mapped CT60-A/G single nucleotide polymorphism (SNP) that is believed control processing production soluble (sCTLA-4).We therefore determined sCTLA-4 protein levels sera from 82 T1D patients 19...
The BRAF‑V600E mutation is the most common and specific oncogenic event known in papillary thyroid carcinoma (PTC). However, it remains controversial whether there an association between clinicopathologically aggressive characteristics of PTC. purpose present retrospective study was to investigate significance predicting prognostic clinicopathological according a new age‑based stratification. Clinical data status 475 patients with PTC were downloaded from Cancer Genome Atlas database....
cDNA microarrays with >11,000 clones from an NOD spleen library were used to identify temporal gene expression changes in mice (1–10 weeks), which spontaneously develop type 1 diabetes, and between congenic (NOD.Idd3/Idd10 NOD.B10Sn-H2b), have near zero incidence of insulitis diabetes. The profiles identified two distinct groups corresponding immature (1–4 weeks) mature (6–10 state. rapid switch occurring around 5 weeks age defines a key immunological checkpoint. Sixty-two known genes...
The survival prediction of patients with chordoma is difficult to make due the rarity this oncologic disease. Our objective was apply a nomogram predict outcomes in individuals skull base, vertebral column, and pelvis. A total 558 between 1973 2014 were collected from Surveillance, Epidemiology, End Results (SEER) database. Independent prognostic factors identified via univariate multivariate Cox analysis. Then these incorporated into 3- 5-year overall cancer-specific rates. Internal...
Objective: The purpose of this study was to investigate critical genes in multiple sclerosis (MS) using microarray data from brain tissue MS.Materials: expression profile set MS (GSE38010) downloaded the Gene Expression Omnibus database contained gene information five plaque tissues brains and two white matter healthy controls. An R package applied process these raw chip data. Ontology (GO) functional analysis, Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis protein–protein...
Diffusion tensor imaging (DTI) provides information about water molecule diffusion in spinal cord. This study was aimed to investigate DTI changes the different stages of compressive cord induced by water-absorbing material implantation. The compression administered over fourth cervical vertebral level rat. Rat models were divided into five subgroups according stages: sham group, group A: three-day rat models; B: 12-day C: 20-day D: 60-day models. including fractional anisotropy (FA) and...
With the development of arthroscopic technology and equipment, arthroscopy can effectively repair tear subscapular muscle. However, it is difficult to expose muscle operate under a microscope. In this study, SwiveLock® C external row anchor was applied in single row, which relatively easy with reliable suture fixation, its efficacy evaluated.This study aimed assess clinical tendon integrity patients who had subscapularis tears by adopting single-row technique anchor.Patients either or...
To explore pro-oxidative state of rotator cuff tissue and expression levels Beclin-1 mam-malian target rapamycin(mTOR) in patients with acute chronic injury, then analyzed relationship between injury oxidative stress autophagy.
BACKGROUND: Circulating proteins in blood are involved various physiological processes, but their contributions to pressure regulation remain partially understood. In traditional observational studies, identifying circulating causally associated with is challenging because of potentially unmeasured confounding and possible reverse causality. METHODS: Two-sample Mendelian randomization analyses were conducted estimate the causal effects 2270 (data sourced from 8 genome-wide association...
Chronic spinal cord compression is the most common cause of impairment in patients with nontraumatic damage. Conventional magnetic resonance imaging (MRI) plays an important role both confirming diagnosis and evaluating degree compression. However, anatomical detail provided by conventional MRI not sufficient to accurately estimate neuronal damage and/or assess possibility recovery chronic patients. In contrast, diffusion tensor (DTI) can provide quantitative results according detection...
Abstract To evaluate changes in knee articular cartilage of amateur marathon runners using magnetic resonance imaging T2 relaxation time mapping. mapping was performed 18 non-professional male 48 h before and 72 after a marathon. Bulk zonal tibiofemoral were assessed. values the left knees (LK) decreased competition (48.45±25.08 versus 39.75±18.91 ms), while those right (RK) similar Significant increases mean times observed RK medial femoral condyle (42.14±8.96 53.63±3.664 ms). There...
Abstract Background Tendinopathy is a chronic injury disease caused by repeated traction. It characterized exercise-related pain, increased local tendon sensitivity, and imaging changes in the tendon. Rotator cuff one of typical tendinopathy. Tendon-derived stem cells (TDSC) play vital role development Our previous studies have found that reactive oxygen species increase after rotator oxidative stress response strengthened, but whether induces TDSC autophagy to promote bone healing not...