A5047562398- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Thyroid Disorders and Treatments
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Ovarian function and disorders
- Adrenal Hormones and Disorders
- Cardiovascular Disease and Adiposity
- Pituitary Gland Disorders and Treatments
- Plant Reproductive Biology
- Thyroid Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Lipoproteins and Cardiovascular Health
- Ophthalmology and Eye Disorders
- Cancer, Lipids, and Metabolism
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Circadian rhythm and melatonin
Gülhane Askerî Tıp Akademisi
1999-2023
Naval Academy
2010-2012
GATA Haydarpaşa Eğitim Hastanesi
2004-2011
Military Medical Academy
1996-2011
Hannover Re (Germany)
2011
Providence College
2011
Acıbadem Adana Hospital
2004-2007
Massachusetts General Hospital
2006
Turkish Armed Forces
2001-2005
Cancer Research And Biostatistics
2005
We have previously demonstrated that genetically based leptin deficiency due to a missense gene mutation in highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism. now performed detailed assessments of endocrine, sympathetic, immune function. also identified new adult female homozygous patient this family who severely obese amenorrheic. In all wild-type heterozgous individuals normal body weight. Seven members family, whom we presume been...
Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether effective treatment fully established morbid obesity and its endocrine metabolic consequences adults. To test hypothesis that has key role regulation adults, we examined effects replacement only three adults identified to date who have genetically based deficiency. We treated these morbidly obese homozygous leptin-deficient adult patients with recombinant at low, physiological doses range...
Abstract Context: Mutations in TAC3 and TACR3 (encoding neurokinin B its receptor) have been identified Turkish patients with idiopathic hypogonadotropic hypogonadism (IHH), but broader populations not yet tested genotype-phenotype correlations established. Objective: A broad cohort of normosmic IHH probands was screened for mutations TAC3/TACR3 to evaluate the prevalence such define genotype/phenotype relationships. Design Setting: The study consisted sequencing TAC3/TACR3, vitro functional...
To determine the significance of serum thyroglobulin (Tg) level in terms presence or absence thyroid cancer, we evaluated available Tg data on and off T4 therapy 180 patients with differentiated cancer who have now been followed up to 18 yr. The was established by radioiodine scans, x-rays, clinical examination. Thirty-two detectable autoantibodies were excluded from this analysis. measured RIA a sensitivity 1 ng/mL. Patients had all stages but no evidence active disease after treatment,...
Leptin signals the status of energy reserves to brain.Leptin stimulates biosynthesis TRH in vitro and influences activity hypothalamic-pituitary-thyroid axis vivo rodents.Because blood levels both leptin TSH display diurnal variation with a distinct nocturnal rise, we sought determine whether relationship exists between fluctuations circulating TSH.We measured serum every 7 min for 24 h five healthy men found that are highly organized pulsatile.A similar pattern rhythms was observed,...
The hormone leptin profoundly affects body weight and metabolism. Three human adults (two women, 35 40 yr old; one man, age 27) have been identified with a recessive mutation in the ob gene, which is homologous to ob/ob mice, produces deficiency morbid obesity. Because replacement increases brain changes protein DNA content we hypothesized that analogous treatment of leptin-deficient humans would alter tissue composition. Volumetric T1-weighted magnetic resonance images were acquired before...
We have previously demonstrated that genetically based leptin deficiency due to a missense gene mutation in highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism. now performed detailed assessments of endocrine, sympathetic, immune function. also identified new adult female homozygous patient this family who severely obese amenorrheic. In all wild-type heterozygous individuals normal body weight. Seven members family, whom we presume been...
Mutations in the melanocortin 4 receptor gene (MC4R) are most common cause of monogenic human obesity. As part our ongoing project entitled ‘Turkish Obesity Genome Study’ we determined nucleotide sequence entire coding region MC4R 40 morbidly obese subjects from independent families. Here report a novel heterozygous mutation (N274S) an adult female individual (age: 52 yrs, BMI 41.7 kg/m2, height 158 cm, weight: 104 Kg). The sister index case 55 height: 160 110 Kg, BMI: 43 kg/m2) also carries...
SUMMARY Although the effects of androgen deficiency in immune system have long been appreciated, little is known about immunological features patients with Klinefelter's syndrome (KS). On other hand, interest androgens as a possible treatment for some autoimmune diseases growing. In present study, parameters were evaluated 26 KS prior to replacement (ART) and results compared those 19 healthy control subjects. Patients then treated testosterone 6 months pre- post-treatment findings compared....
BACKGROUND: The obese are usually protected against osteoporosis and have increased bone mineral density plasma leptin concentrations. A recent in vitro study demonstrated that acts on human marrow stromal cells to enhance differentiation osteoblasts, suggesting an influence of mass. However, little is known about the relationship between mass postmenopausal women with osteoporosis. OBJECTIVE: To investigate concentrations improve understanding role determining METHODS: Fifty (ages...
KISS1 is a candidate gene for GnRH deficiency.Our objective was to identify deleterious mutations in KISS1.DNA sequencing and assessment of the effects rare sequence variants (RSV) were conducted 1025 probands with GnRH-deficient conditions.Fifteen harbored 10 heterozygous RSV seen less than 1% control subjects. Of that reside within mature kisspeptin peptide, p.F117L (but not p.S77I, p.Q82K, p.H90D, or p.P110T) reduces inositol phosphate generation. lie coding region but outside p.G35S...
To determine the frequency of rare nucleotide variants in GNRHR and GPR54 a large cohort probands (n = 166) with normosmic idiopathic hypogonadotropic hypogonadism (nIHH), characterized by mode inheritance, testicular volume, presence or absence endogenous LH pulsations.Whenever possible, answered detailed questionnaires, underwent full physical exams, q 10-min frequent blood sampling for LH. Exons segments were screened mutations. Nucleotide changes identified as if they occurred at less...
Subclinical hypothyroidism is a frequent disorder in populations and has been shown to be risk factor for coronary heart disease (CHD). Less known about the contribution of lipoprotein (a) [Lp(a)] development CHD this disorder. Therefore study was designed evaluate Lp(a) other concentrations before after L-T4 therapy 20 patients with subclinical normal healthy subjects matched sex, age BMI. In basal state hypothyroidism, significant increase total cholesterol, LDL-cholesterol apolipoprotein...
OBJECTIVES: To measure plasma adiponectin concentrations in patients with type 2 diabetes and to investigate any association the severity of diabetic retinopathy, because seems be an important modulator for metabolic vascular diseases. METHODS: Seventy-four (mean age 46.8+/-5.1 years; body mass index (BMI), 26.8+/-2.10 kg/m(2)) 54 healthy volunteers 46.8+/-5.4 BMI 26.47+/-2.33 were included. RESULTS: Adiponectin significantly lower than those controls (4.71+/-2.11 microg/ml patients, n=74;...
There is a significant line of evidence for role androgens in the modulation immune system. However, little known about immunological features male patients with idiopathic hypogonadotropic hypogonadism (IHH) and potential effects gonadotropin treatment. Thus, objective this study was to evaluate levels selected soluble parameters [IgA, IgG, IgM, C3c, C4, interleukin-2 (IL-2), IL-4], CD4+/CD8+ ratio, counts total lymphocyte some subpopulation lymphocytes (CD3+, CD4+, CD8+, CD19+ cells)...
The aim of this study was to investigate the effects combined hypocaloric diet and metformin on circulating testosterone leptin levels in obese men with or without type 2 diabetes.Twenty diabetes (mean body mass index [BMI]: 35.5 +/- 1.1 kg/m(2)) 20 nondiabetic were enrolled study. We measured serum follicle-stimulating hormone, luteinizing hormone (LH), total (TT), free (FT), sex-hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), plasma before 3 months after treatment....
Obesity is a growing problem and associated with numerous medical conditions. In several genes coding for molecules involved in the regulation of body weight (fat mass) thermogenesis, polymorphisms have been reported which possibly modify human obesity risk. The aim this study was to determine incidence following 262 obese (BMI≥30) 138 control (BMI≤25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)-a 44-base pair insertion/deletion...
Hypothyroidism has a broad clinical spectrum. Today, physicians frequently encounter patients with very mild thyroid dysfunction instead of overt hypothyroidism. These have normal serum levels thyroxine and triiodothyronine only mildly elevated thyrotropin levels. Such are often identified through routine screening or in the course an evaluation common nonspecific symptoms. On other hand, coronary heart disease is leading cause death developed countries. There studies, which suggest...