A5101775689- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Plant Reproductive Biology
- Regulation of Appetite and Obesity
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Sperm and Testicular Function
- Islamic Finance and Communication
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- SMEs Development and Digital Marketing
- Ureteral procedures and complications
- Peroxisome Proliferator-Activated Receptors
- PARP inhibition in cancer therapy
- Primate Behavior and Ecology
- Sepsis Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Healthcare Systems and Public Health
- Urinary Tract Infections Management
- Neonatal and fetal brain pathology
- Diabetic Foot Ulcer Assessment and Management
- Halal products and consumer behavior
German Primate Center
2015-2021
Pakistan Institute of Engineering and Applied Sciences
2021
Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology
2021
University of Science and Technology of China
2019
Quaid-i-Azam University
2008-2015
Khyber Medical University
2012-2015
Universidade de São Paulo
2013-2015
Clinics Hospital of Ribeirão Preto
2014
Reproductive Science Center
2011
Massachusetts General Hospital
2011
KISS1 is a candidate gene for GnRH deficiency.Our objective was to identify deleterious mutations in KISS1.DNA sequencing and assessment of the effects rare sequence variants (RSV) were conducted 1025 probands with GnRH-deficient conditions.Fifteen harbored 10 heterozygous RSV seen less than 1% control subjects. Of that reside within mature kisspeptin peptide, p.F117L (but not p.S77I, p.Q82K, p.H90D, or p.P110T) reduces inositol phosphate generation. lie coding region but outside p.G35S...
Irisin, encoded by the FNDC5 gene, is a recently discovered endocrine factor mainly secreted as myokine and adipokine. However, irisin/FNDC5 expression has also been reported in different other organs including components of reproductive axis. Yet, there scarcity data on FNDC5/irisin expression, regulation its effects, particularly primates. Here, we report FNDC5/irisin, along with PGC1A (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) ERRA (estrogen-related alpha),...
Fasting suppresses functioning of the hypothalamic-pituitary-gonadal (HPG) axis by mechanisms that are incompletely understood. In 2003, hypothalamic kisspeptin-Kiss1r signaling was discovered to play a significant role in regulating HPG axis. We have recently shown adult male macaques, short-term fasting attenuates response an exogenous kisspeptin challenge. present study, we explored mechanism underlying this attenuated examining modulation expression Kiss1 and Kiss1r under normal feeding...
The digital revolution in the Islamic banking sector Indonesia marks a pivotal transformation from conventional service models to technology-driven, Sharia-compliant financial solutions. This article explores how innovation fosters development of services Indonesia. Utilizing qualitative-descriptive approach, this research examines integration platforms, including mobile banking, fintech sharia, and blockchain, creating inclusive transparent ecosystems. study also highlights role regulatory...
Kisspeptin (KP)-Kiss1r, a ligand-receptor pair, has recently been implicated as pivotal regulator of the neuroendocrine reproductive axis. Kiss1 (encoding KP) well Kiss1r receptor for are expressed in several peripheral tissues including pancreas. But specific role KP physiology pancreas is still incompletely deciphered. This study was designed to examine effect administration on basal and glucose-induced plasma insulin (an important pancreatic hormone) secretion under fed fasting conditions...
Kisspeptin-Kiss1R signalling in mammals has been implicated as an integral part of the reproductive cascade. Kisspeptinergic neurons upstream GnRH are involved activation hypothalamic pulse generator during pubertal onset. Thus, major research focus on central effects kisspeptin. The demonstration presence KissR expression human testes suggests additional unknown actions kisspeptin-KISS1R at distal component male axis. Here we explored impact kisspeptin testis adult rhesus monkey. We...
In the last few years, kisspeptin-KISS1R signaling has appeared as a major regulator of reproductive function in several vertebrate species. However, KISS1(encoding kisspeptin) and its putative receptor, KISS1R, are expressed other tissues. Adipose tissue, which secretes many peptides with diverse functions normal physiology, expresses KISS1, is modulated by gonadal steroids well body nutritional status. Similarly, KISS1Rexpression also found adipose but local role kisspeptin adipocyte...
Objective: To identify knowledge and practises of nurses regarding infection control in the use urethral catheter associated urinary tract private tertiary care hospital Peshawar. Purpose: The purpose this study was to explore current care. also focused on standard guidelines about hospitals. Method: A descriptive cross sectional conducted among Participants were selected through convenient sampling technique. data collected a self-developed structured questionnaire. Results: Out 70...
Recently, hypothalamic RFRP-3 (a mammalian ortholog of avian GnIH) signaling has been proposed as an important negative modulator the reproductive axis. The current study examined whether repression hormonal expression during short-term fasting conditions in higher-order primate is influenced by altered signaling. Eight intact postpubertal male macaques (<i>Macaca mulatta</i>) were administered a single intravenous bolus RF-9 (n=4), potent and putative receptor antagonist, or vehicle (n=4)...
The neurobiological mechanism of puberty onset in primates is currently only partly understood. A recent study reported an important role Dmx-like 2 (DMXL2), a gene encoding rabconnectin-3α vesicular protein, human subjects with mental retardation and neuroendocrine impairment reproduction. To further characterize the potential DMXL2 regulation reproduction, we analyzed expression hypothalami newborn, infantile, juvenile, pubertal, postpubertal female male common marmoset monkeys....