A5088204310- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Plant Reproductive Biology
- Regulation of Appetite and Obesity
- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
- Effects of Environmental Stressors on Livestock
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Supercapacitor Materials and Fabrication
- Advanced battery technologies research
- Thyroid Cancer Diagnosis and Treatment
- Animal Genetics and Reproduction
- Shoulder Injury and Treatment
- Herpesvirus Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- Conducting polymers and applications
- Nerve Injury and Rehabilitation
- Shoulder and Clavicle Injuries
Beijing University of Chemical Technology
2022-2024
Guangdong Medical College
2024
Cloud Computing Center
2024
The University of Agriculture, Peshawar
2023
Civil Hospital Karachi
2019-2023
Cavan General Hospital
2023
Mayo Hospital
2023
Aintree University Hospitals NHS Foundation Trust
2023
University of Liverpool
2023
Technological University Dublin
2023
To further study the role of GPR54 signaling in onset primate puberty, we used monkey to examine ability kisspeptin-10 elicit release gonadotropin-releasing hormone (GnRH) precociously, and describe expression KiSS-1 hypothalamus during peripubertal period. Agonadal juvenile male monkeys were implanted with a lateral cerebroventricular cannula jugular vein catheter. The responsiveness pituitary endogenous GnRH was heightened chronic pulsatile i.v. infusion synthetic before (112-121)...
Kisspeptins are the product of Kiss1 gene and potently stimulate GnRH secretion. In sheep, mRNA-expressing cells found in arcuate nucleus (ARC) dorsal-lateral preoptic area both appear to mediate positive feedback effect estradiol generate preovulatory GnRH/LH surge. To determine role kisspeptin transmitting estrogen-positive hypothalamus, we administered antagonist p-271 ewes subjected an benzoate-induced LH Kisspeptin treatment significantly attenuated these surges. We further examined...
Kisspeptin, the product of KISS1 gene, stimulates gonadotropin-releasing hormone (GnRH) secretion; gonadotropin inhibitory (GnIH), encoded by RF-amide-related peptide (RFRP) or NPVF inhibits reproductive axis. In sheep, kisspeptin neurons are found in lateral preoptic area (POA) and arcuate nucleus (ARC) may be important for initiating preovulatory GnRH/luteinizing (LH) surge. GnIH cells located ovine dorsomedial hypothalamic (DMN) paraventricular (PVN), with similar distribution primate....
Irisin, encoded by the FNDC5 gene, is a recently discovered endocrine factor mainly secreted as myokine and adipokine. However, irisin/FNDC5 expression has also been reported in different other organs including components of reproductive axis. Yet, there scarcity data on FNDC5/irisin expression, regulation its effects, particularly primates. Here, we report FNDC5/irisin, along with PGC1A (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) ERRA (estrogen-related alpha),...
In this study, we report one-pot, single step synthesis of silver nanoparticles stabilized by using arbutin. The concentration reducing agent (NaBH4) used in the preparation was kept at double, and arbutin as a stabilizing agent. confirmation prepared done color change UV-Vis surface plasmon resonance peak 435 nm spectrum. Size dispersion carried out Dynamic Light Scattering (DLS) charge on nanoparticles. Stability analyzed Zeta potential. A strong negative indicated that are well throughout...
By encompassing a wide range of best practices within the ever-changing realm modern surgical care, this exhaustive narrative compendium attempts to unravel complex tapestry novel approaches safe surgery. Within context dynamic environment, research endeavors illuminate and integrate state-of-the-art methods that collectively methodically improve patient safety. The elucidates diverse array seek revolutionize paradigm surgery, emphasizing technological progress, patient-centric approaches,...
ABSTRACT The present study was designed to investigate the relative contributions of FSH and testosterone in initiation testicular growth function primates. Four groups ( n = 4/group) juvenile rhesus monkeys Macaca mulatta ), 12–18 months old, were treated with vehicle, a highly purified human preparation (hFSH; Fertinorm, 3 IU/kg per day), (testosterone enanthate, 125 mg/week) or plus testosterone, for period 12 weeks. Compared vehicle treatment, administration hormones significantly P...
The present study was conducted to examine the effect of organochlorine (Heptachlor, Benzene hexachloride (BHC)), organophosphorus (Malathion, Monitor) and pyrethroid (Karate, Talstar) insecticides on thyroid secretory function in rats. Heptachlor (0.5 mg per rat), BHC (0.66 rat) Malathion (0.06 Monitor (0.2 Karate Talstar were orally administered young adult rats for 21 days. Serum concentrations triiodothyronine (T3), thyroxine (T4) thyrotrophin (TSH) determined by using specific...
Fasting suppresses functioning of the hypothalamic-pituitary-gonadal (HPG) axis by mechanisms that are incompletely understood. In 2003, hypothalamic kisspeptin-Kiss1r signaling was discovered to play a significant role in regulating HPG axis. We have recently shown adult male macaques, short-term fasting attenuates response an exogenous kisspeptin challenge. present study, we explored mechanism underlying this attenuated examining modulation expression Kiss1 and Kiss1r under normal feeding...
Objective: to evaluate the knowledge, attitudes, and practices of operating theatre staff concerning CAUTI prevention at Health Sciences, Superior University, Lahore, Pakistan. Study Design: A Cross sectional Place Duration Study: cross-sectional study was performed with theater personnel, comprising physicians, nurses, technicians, Lahore. Methodology: standardized questionnaire employed assess participants' understanding causes, dangers, preventative measures; attitudes towards prevention;...
Objective: This study sought to compare the haemodynamic responses laryngoscopy and tracheal intubation between Nalbuphine Midazolam assess their efficacy safety in clinical practice. Study Design: A Randomized Control Trial (RCT) Place Duration of Study: Department Anesthesia at Faculty Allied Health Sciences, Superior University, Lahore duration was six months from jan 2024 june Materials Methods: randomized controlled experiment performed Sciences involving 168 people, evenly split into...
Galanin-like peptide (GALP) is a hypothalamic neuropeptide that has been implicated in the control of feeding, metabolism, and reproduction. The goal this study was to examine effects central infusions GALP on GnRH LH secretion identify physiological factors influence expression mRNA brain primate species. Infusions into lateral cerebroventricle macaque caused significant increase secretion, which blocked by administration receptor antagonist acyline. However, arcuate nucleus, as determined...
Kisspeptin (KP)-Kiss1r, a ligand-receptor pair, has recently been implicated as pivotal regulator of the neuroendocrine reproductive axis. Kiss1 (encoding KP) well Kiss1r receptor for are expressed in several peripheral tissues including pancreas. But specific role KP physiology pancreas is still incompletely deciphered. This study was designed to examine effect administration on basal and glucose-induced plasma insulin (an important pancreatic hormone) secretion under fed fasting conditions...
BackgroundViral respiratory tract infections are the leading cause of acute illness during infancy and closely linked to chronic inflammatory airway diseases later in life. However, determinants susceptibility still need be defined.ObjectiveWe investigated whether individual variation antiviral response at birth determines risk for first year life.MethodsWe studied 82 children who were enrolled a cohort study inner-city with least 1 parent allergy or asthma. We cultured cord blood monocytes...
Kisspeptin-Kiss1R signalling in mammals has been implicated as an integral part of the reproductive cascade. Kisspeptinergic neurons upstream GnRH are involved activation hypothalamic pulse generator during pubertal onset. Thus, major research focus on central effects kisspeptin. The demonstration presence KissR expression human testes suggests additional unknown actions kisspeptin-KISS1R at distal component male axis. Here we explored impact kisspeptin testis adult rhesus monkey. We...