A5004846116- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Liver Disease and Transplantation
- Hepatitis C virus research
- Diet and metabolism studies
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neural Network Applications
- Prostate Cancer Diagnosis and Treatment
- bioluminescence and chemiluminescence research
- Liver Diseases and Immunity
- Chemical Reactions and Isotopes
- HIV-related health complications and treatments
- Medical Image Segmentation Techniques
- Medical Imaging and Analysis
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- Mass Spectrometry Techniques and Applications
University of California System
2022
University of California, San Francisco
2015-2021
University of California, Berkeley
2018
San Francisco VA Medical Center
2016
MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this project, we applied HP [1‐ 13 C]pyruvate dynamic prostate measure the conversion from lactate, which expected increase aggressive cancers. The goal work was develop test analysis methods improved quantification metabolic conversion. work, compared specialized kinetic modeling estimate pyruvate‐to‐lactate rate, k P...
Agents targeting prostate-specific membrane antigen (PSMA) comprise a rapidly emerging class of radiopharmaceuticals for diagnostic imaging prostate cancer. Unlike most other PSMA agents with urea backbone, CTT1057 is based on phosphoramidate scaffold that irreversibly binds to PSMA. We conducted first-in-humans phase I study in patients localized and metastatic <b>Methods:</b> Two patient cohorts were recruited. Cohort A had biopsy-proven cancer preceding radical prostatectomy, cohort B...
Hepatic steatosis (HS) is common in individuals with hepatitis C virus (HCV) and human immunodeficiency (HIV) infections, but the independent contributions of HCV HIV to HS are unclear. Magnetic resonance imaging spectroscopy were used measure visceral adipose tissue (VAT) liver fat fraction (LFF) (total lipids/[total lipids + water]) 356 adults: 57 monoinfection, 70 HIV/HCV coinfection, 122 107 neither infection. Participants who infected genotype 3 excluded because genotype's reported...
Background: Hepatic steatosis is increasing worldwide. Whether HIV and its associated metabolic perturbations exacerbate unclear. Sex differences in adipose tissue distribution may also affect risk. We examined the contribution of sex to steatosis. Methods: Using MRI spectroscopy, visceral (VAT) liver fat fraction (LFF) were measured 121 HIV-infected 107 uninfected men women without viral hepatitis. Differences LFF by status evaluated using multivariable linear regression, adjusting for...
There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of tumors such as a decrease in extracellular pH (pHe) can potentially be used identify phenotypes. In this study, we employ optimized, high signal-to-noise ratio hyperpolarized (HP) 13C pHe method discriminate between disease murine model Transgenic adenocarcinoma the mouse (TRAMP) mice underwent multiparametric MR exam, including HP [13C] bicarbonate MRI...
Hepatic steatosis is common in HIV-infected individuals. Magnetic resonance spectroscopy (MRS) the preferred noninvasive method for hepatic measurement but expensive. Controlled attenuation parameter (CAP) also assesses and conveniently performed concomitantly with transient elastography. We aimed to assess accuracy of CAP setting HIV infection.Cross-sectional study.CAP MRS were 82 study participants (39 monoinfected; seven hepatitis C virus (HCV) 21 HIV/HCV coinfected; 15 neither...
Hepatic steatosis is a leading cause of cirrhosis and hepatocellular carcinoma highly prevalent in persons with HIV (PWH). However, most studies hepatic diagnosis PWH have focused on those at high risk. We determined the accuracy vibration-controlled transient elastography (VCTE) controlled attenuation parameter (CAP) detecting mild or greater as compared noninvasive gold standard magnetic resonance spectroscopy (MRS) PWH.Among 149 participants without HIV, we evaluated test characteristics...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential organ- or tumor-imaging agents. 18. Radioiodinated diamines and bisquaternariesC. C. Huang, N. Korn, R. E. CounsellCite this: J. Med. Chem. 1979, 22, 4, 449–452Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/jm00190a018https://doi.org/10.1021/jm00190a018research-articleACS PublicationsRequest reuse permissionsArticle...
Purpose: A conventional 2D UNet convolutional neural network (CNN) architecture may result in ill-defined boundaries segmentation output. Several studies imposed stronger constraints on each level of to improve the performance UNet, such as SegNet. In this study, we investigated SegNet and a proposed conditional random field insert (CRFI) for zonal prostate from clinical T2-weighted MRI data. Methods: We introduced new methodology that combines CRFI accuracy robustness segmentation. has...
Introduction: Hepatic steatosis (HS) is common in HIV-infected individuals and expected to increase with rises obesity the metabolic syndrome. Controlled attenuation parameter (CAP) a noninvasive technique assess HS that has been validated patients various liver diseases. Moreover, because CAP measurements can be obtained at same time as transient elastography, it convenient method HS. Although increasingly being used screen for persons, limited data exist on its accuracy this population....
Abstract Hyperpolarized 13 C MR is a novel medical imaging modality with substantially different signal dynamics as compared to conventional 1 H MR, thus requiring new methods for processing the data in order access and quantify embedded metabolic functional information. Here we describe step-by-step analysis protocols renal hyperpolarized imaging. These are useful investigating blood flow function well status of rodents vivo under various experimental physiological conditions. This chapter...