A5050816193- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Transgenic Plants and Applications
- Neuroblastoma Research and Treatments
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Cystic Fibrosis Research Advances
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Animal Genetics and Reproduction
- Chemical Reactions and Isotopes
- Advanced biosensing and bioanalysis techniques
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Plant biochemistry and biosynthesis
- Cellular Mechanics and Interactions
- Estrogen and related hormone effects
- TGF-β signaling in diseases
Cancer Targeted Technology (United States)
2016-2025
Sunny BioDiscovery (United States)
1998
Bayer (Germany)
1996
Pacific Biosciences (United States)
1989-1992
University of California, Davis
1985-1991
University of California, Los Angeles
1978
Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents prostate cancer various non-prostatic tumors that are characterized by PSMA expression on their neovasculature.One of the challenges inhibitors with respect delivering payloads is rapid renal clearance.In order overcome this pharmacokinetic challenge, we outfitted a 177 Lu-labeled phosphoramidate-based inhibitor (CTT1298) albumin-binding motif...
PURPOSE An enzyme-linked immunosorbent assay (ELISA) for the extracellular domain of c-erbB-2 oncogene product was developed and evaluated to determine if soluble could be detected in serum effusions cancer patients. PATIENTS AND METHODS Sera from 208 previously untreated or progressing patients 69 healthy controls were assayed a double-antibody sandwich ELISA that used two monoclonal antibodies native receptor. Fisher's exact test analyze statistical significance frequency elevated levels....
To determine whether the enhanced expression of transforming growth factor alpha (TGF alpha) is sufficient to induce neoplastic transformation an immortalized population mammary epithelial cells, we cotransfected NOG-8 a cloned mouse cell line, with simian virus 40-human TGF cDNA vector plasmid and pSV2neo plasmid. After cotransfection, nine G418-resistant colonies were expanded. All clones subsequently analyzed for mRNA by northern blot analysis, secretion, anchorage-dependent in serum-free...
Monomethyl auristatin E (MMAE) is a promising treatment option for patients diagnosed with prostate cancer (PCa); however, toxicities prevent MMAE from being administered as free drug. No MMAE-based currently marketed PCa. Herein, we describe small-molecule-drug conjugate, CTT2274, the selective delivery of MMAE. CTT2274 composed prostate-specific membrane antigen (PSMA)-binding scaffold, biphenyl motif, pH-sensitive phosphoramidate linker, and payload. We demonstrate that shows binding to...
Agents targeting prostate-specific membrane antigen (PSMA) comprise a rapidly emerging class of radiopharmaceuticals for diagnostic imaging prostate cancer. Unlike most other PSMA agents with urea backbone, CTT1057 is based on phosphoramidate scaffold that irreversibly binds to PSMA. We conducted first-in-humans phase I study in patients localized and metastatic <b>Methods:</b> Two patient cohorts were recruited. Cohort A had biopsy-proven cancer preceding radical prostatectomy, cohort B...
Abstract Human transforming growth factor alpha (TGF alpha) is a 50-residue mitogenic peptide with compact structure restrained by three disulfide bonds. Sequential and overlapping synthetic peptides were made to identify epitopes of TGF using panel murine monoclonal antibodies rabbit polyclonal antibodies. Antibodies raised against human from different preparations obtained either chemical synthesis or recombinant DNA techniques. Two related methodologies used in these experiments. In the...
Transforming growth factor alpha (TGF-alpha) is a polypeptide regulator of cell produced by many malignant tumors. It stimulates osteoclastic resorption in bone organ culture and osteoclast-like formation marrow culture. To determine whether tumor production TGF-alpha can cause hypercalcemia vivo, we used Chinese hamster ovarian (CHO) cells transfected with the human gene (TCHO), which stably express secrete TGF-alpha. We nontransfected CHO as controls (CCHO). TCHO CCHO were inoculated...
Serially transplantable rat mammary tumor (RMT) cells are not dependent on exogenous epidermal growth factor (EGF) and insulin-like factor-I for continuous in serum-free medium. Previously, we found that conditioned medium obtained from these contained EGF-like mitogenic activity stimulated tyrosine phosphorylation of a 185-kDa protein EGF-dependent epithelial cells. This is distinct the EGF receptor resembles tyrosine-phosphorylated present RMT themselves. The results studies reported here...
Progressive lung damage in cystic fibrosis (CF) has been linked to inadequate airway mucosal hydration. We previously demonstrated that an inositol tetrakisphosphate analog, 1-O-octyl-2-O-butyryl-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester (INO-4995), regulates secretory and absorptive processes, affecting hydration by prolonged (24 h) inhibition of Na(+) fluid absorption CF human nasal epithelia (CFHNE). The objectives this study were further assess clinical...
Abstract The protein Ag, tobacco mosaic virus protein, (TMVP) and its tryptic peptide number 8 (residues 93-112 of the protein) exhibit cross-reactivity on T cell level in some strains mice (e.g., C3H.SW, C57BL/10); these are termed cross-reactive (CR). In other such as A/J or B10.BR, no is exhibited; non-cross-reactive (NCR). Genetic experiments indicated that dominant it mapped to I-A I-E region MHC, with exhibited by I-Ab haplotype but not I-Ak I-Ek. Cell reconstitution have...
e16562 Background: Urea-based 68 Ga-PSMA PET is increasingly being utilized for diagnostic purposes in prostate cancer; however high tracer uptake within the salivary gland and kidney may be dose-limiting upon translation to radiotherapy. We developed a novel 18 F labeled agent, CTT1057, PSMA inhibitor based on phosphoramidate scaffold with nanomolar irreversible binding affinity robust internalization, performed first-in-human imaging study. Methods: Patients (pts) metastatic castration...