A5031033896- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV Research and Treatment
- HIV-related health complications and treatments
- Cervical Cancer and HPV Research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Viral gastroenteritis research and epidemiology
- Fungal Infections and Studies
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Gut microbiota and health
- Cancer-related gene regulation
- Frailty in Older Adults
- Pneumocystis jirovecii pneumonia detection and treatment
University at Albany, State University of New York
2017-2025
Albany State University
2017-2025
VA Connecticut Healthcare System
2024
GTx (United States)
2017-2021
Johns Hopkins University
2006-2016
Albert Einstein College of Medicine
2009-2016
University of Southern California
2010-2016
Georgetown University
2010-2016
Georgetown University Medical Center
2010-2016
University of California, San Francisco
2010-2016
Hepatitis E virus (HEV) is prevalent and causes disease worldwide, but its epidemiological profile only partially understood.We used an enzyme immunoassay to measure anti-HEV immunoglobulin G antibodies in 18,695 serum samples collected the Third National Health Nutrition Examination Survey. We calculated estimates of HEV seroprevalence examined associations with putative risk factors.The civilian noninstitutionalized United States (US) population during period from 1988 through 1994 was...
Characterizing the genetically diverse HIV sequences that persist in reservoir despite antiretroviral therapy (ART) is critical to cure efforts. Our observations confirm proviruses persisting blood on ART, which are largely defective, broadly reflect extent of within-host evolution pre-ART. Moreover, on-ART clonal expansion not appreciably accompanied by loss distinct proviral lineages. In fact, genetic composition remained stable all but one participant, whom, after 12 years dating around...
Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done document burden distribution of these pathogens. We tested serum samples 256 Cameroonian adults nine rural villages for presence Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), Tahyna (TAH) infection using standard plaque-reduction neutralization...
The main objectives of this study were to define the occurrence and levels hepatitis B virus (HBV) DNA in asymptomatic HBV carriers, cirrhosis patients hepatocellular carcinoma (HCC) cases from Gambia, evaluate risk for or HCC associated with viremia. We used sensitive real-time quantitative PCR assays measure samples a case-control consisting 60 53 cirrhotic 129 cases. Logistic regression was estimate risks HBV-DNA e antigenemia (HBeAg) detection (a surrogate marker viral replication)....
Studies of human leukocyte antigen (HLA) alleles and their relation with hepatitis C virus (HCV) viremia have had conflicting results. However, these studies varied in size methods, few large assessed HLA class I alleles. Only one study conducted high-resolution genotyping. The current investigation therefore involved II genotyping a multiracial cohort U.S. women high prevalence HCV HIV. Our primary analyses evaluated associations between 12 identified through critical review the literature...
Abstract Human papillomavirus (HPV) natural history has several characteristics that, at least from a statistical perspective, are not often encountered elsewhere in infectious disease and cancer research. There are, for example, multiple HPV types, infection by each type may be considered separate events. Although concurrent infections common, the prevalence, incidence, duration/persistence of individual can separately measured. However, repeated measures involving same subject tend to...
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti–hepatitis C virus (HCV)–positive participants the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P 3.3 × 10−5) than IFNL4-TT/ΔG (11.3%; OR, 0.95; .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data published results 1678), ORs were 3.84 (P 8.6 10−14) and 1.44 .03)...
Cirrhosis of the liver is thought to be a major cause morbidity and mortality in sub-Saharan Africa, but few controlled studies on etiology cirrhosis have been conducted this region.We aimed elucidate association between environmental infectious exposures The Gambia.Ninety-seven individuals were diagnosed with using validated ultrasound scoring system compared 397 controls. Participants reported demographic food frequency information. Blood samples tested for hepatitis B surface antigen...
ABSTRACT Cryptococcus neoformans is one of the most common causes fungal disease in HIV-infected persons, but not all those who are infected develop cryptococcal (CD). Although CD4 + T cell deficiency a risk factor for HIV-associated CD, polymorphisms phagocytic Fc gamma receptors (FCGRs) have been linked to CD HIV-uninfected persons. To investigate associations between FCGR2A 131 H/R and FCGR3A 158 F/V we performed PCR-based genotyping on banked samples from 164 men enrolled Multicenter...
Prevalence of hepatitis C virus (HCV) antibody has been reported in Mexican Americans, but its prevalence other US Hispanic/Latino groups is unknown. We studied 2 populations adults; 3210 from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 11 964 Hispanic Community Study/Study Latinos (HCHS/SOL). Age-standardized HCV was similar NHANES (1.5%) HCHS/SOL (2.0%) differed significantly by background (eg, 11.6% Puerto Rican men vs 0.4% South American men). These findings...
Abstract Background The HIV‐1 reservoir in CD4+ T cells (HR CD4 ) pose a major challenge to curing HIV, with many of its mechanisms still unclear. DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing replication. Methods This study used bisulphite capture methylation sequencing from blood 427 virally suppressed women HIV identify differentially methylated sites regions associated HR . Results average total size was 1409 copies per million...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people living with HIV. Gut microbial translocation and gut damage may play a role MASLD pathogenesis. We determined associations of circulating biomarkers hepatic steatosis fibrosis large US cohort women HIV (WWH) without Vibration controlled transient elastography (VCTE) was conducted from 2013-2018 among 854 WWH 349 Serum were measured within 6 months the VCTE: kynurenine to tryptophan (KT) ratio,...
Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency (HIV) coinfection U.S.We tested 2,919 plasma samples collected from HIV-infected (HIV(+)) women and men enrolled U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT(+) were confirmed by real-time polymerase chain reaction. Samples selected primarily basis biomarkers liver disease immune suppression. Prevalence...
Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected individuals with cryptococcal meningitis places them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The relationship between antibody immunity and C-IRIS has not been investigated.
The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total levels peripheral blood B cell subsets 12 previously healthy patients with cryptococcosis (cases) 21 controls. Before after adjustment for age, sex, race, cryptococcal capsular polysaccharide immunoglobulin G was higher cases than controls, whereas memory were lower. These associations parallel previous findings human immunodeficiency...
Abstract Control of hepatitis C virus (HCV) in hemodialysis populations is a major public health priority, but the preferred methods to prevent and rapidly detect HCV outbreaks these remains subject debate. We enrolled 231 patients at three dialysis centers Chiang Mai, Thailand. Patients were followed every 6 months for 3 years tested presence serum antibody RNA each visit. additionally isolated peripheral blood mononuclear cells (PBMCs) collected 30‐month follow‐up Fifty‐one study...
Georgia has a high prevalence of hepatitis C, with 5·4% adults chronically infected. On April 28, 2015, launched national programme to eliminate C by 2020 (90% reduction in prevalence) through scaled-up treatment and prevention interventions. We evaluated the interim effect feasibility achieving elimination goal.
Non-alcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic/Latinos and rates of NAFLD vary among Hispanics from different background groups. Genetic variants continental ancestry contribute to disparities Hispanics. We evaluated two newly identified NAFLD-associated single nucleotide polymorphisms HSD17B13, rs72613567:TA rs62305723:A in Hispanics/Latinos.Clinical data, genotypes interest estimates were extracted the Hispanic Community Health Study/Study Latinos (HCHS/SOL)...