A5053694276- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Systemic Lupus Erythematosus Research
- Biochemical and Structural Characterization
- Diabetes and associated disorders
- Crop Yield and Soil Fertility
- Global Maternal and Child Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Agricultural pest management studies
- Olfactory and Sensory Function Studies
- Rice Cultivation and Yield Improvement
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Myeloma Research and Treatments
- Biochemical Analysis and Sensing Techniques
- Child Nutrition and Water Access
- Bioenergy crop production and management
All India Institute of Medical Sciences Bhubaneswar
2022-2025
La Jolla Institute for Immunology
2019-2024
Augusta University Health
2024
Augusta University
2024
Bangladesh Agricultural Research Institute
2023
Indian Institute of Technology Madras
2022
Bangladesh Agricultural University
2014-2021
National Institute of Immunology
2015-2020
JSS Medical College and Hospital
2015
JSS Academy of Higher Education and Research
2015
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting odorants sense smell. We found mouse vascular macrophages express olfactory receptor
Long coronavirus disease (COVID) or postacute sequelae of 2019 (COVID-19) is widely reported but the data long COVID after infection with Omicron variant limited. This study was conducted to estimate incidence, characteristics symptoms, and predictors among COVID-19 patients diagnosed during wave in Eastern India. The cohort included were adults (≥18 years) as severe acute respiratory syndrome 2 positive Reverse Transcription Polymerase Chain Reaction. After 28 days diagnosis; participants...
Tissue microenvironment functions as an important determinant of the inflammatory response elicited by resident cells. Yet, underlying molecular mechanisms remain obscure. Our systems-level analyses identified a duration code that instructs stimulus specific crosstalk between TLR4-activated canonical NF-κB pathway and lymphotoxin-β receptor (LTβR) induced non-canonical signaling. Indeed, LTβR costimulation synergistically enhanced late RelA/NF-κB to TLR4 prolonging target gene-expressions....
Environmental drug resistance constitutes a serious impediment for therapeutic intervention in multiple myeloma. Tumor-promoting cytokines, such as tumor necrosis factor (TNF), induce nuclear factor-κB (NFκB)- driven expression of pro-survival factors, which confer myeloma cells to apoptotic insults from TNF-related apoptosis-inducing ligand (TRAIL) and other chemotherapeutic drugs. It is thought that RelA:p50 dimer, activated IκBα-inhibited complex response TNF-induced canonical NFκB...
Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) transcript single-cell (sc)RNA sequencing (scRNA-seq) PBMCs.
Abstract Background: The mankind has been fighting the pandemic of COVID-19 for last few years and vaccines came in as a real game changer by end 2020. World’s biggest vaccination drive was started India on January 16, 2021. A year later, were introduced adolescent population. concern over Adverse Events Following Immunization (AEFI) surfaced dampened vaccine uptake with increasing fear misinformation toward vaccination. AEFI is any untoward medical occurrence that follows immunization, not...
Despite the decades-old knowledge that males and people with diabetes mellitus (DM) are at increased risk for coronary artery disease (CAD), reasons this association only partially understood. Among immune cells involved, recent evidence supports a critical role of T as drivers modifiers CAD. CD4+ commonly found in atherosclerotic plaques. We aimed to understand relationship CAD sex DM by single-cell RNA (scRNA-Seq) antibody sequencing (CITE-Seq) cells. Peripheral blood mononuclear (PBMCs)...
Single-cell RNA-sequencing (scRNA-Seq) is widely used to characterize immune cell populations. However, mRNA levels correlate poorly with expression of surface proteins, which are well established define types. CITE-Seq (cellular indexing transcriptomes and epitopes by sequencing) utilizes oligonucleotide-tagged antibodies simultaneously analyze phenotypes transcriptomes. Considering the high costs adding phenotyping scRNA-Seq, we aimed determine 188 tested can detect their antigens on human...
Background: Women's sexual dysfunction is found to be highly prevalent in western and Indian literature. Limited studies are available on drug naive depression literature population. Aim: To determine the prevalence rate symptom profile of female dysfunctions patients with untreated depression. Design: A cross-sectional study psychiatry out-patient department general hospital South India. Materials Methods: Following written informed consent functioning index (FSFI) Arizona Sexual Experience...
Background: CD (cluster of differentiation) 4 + T-cell responses to APOB (apolipoprotein B) are well characterized in atherosclerotic mice and detectable humans. CD4 T cells recognize antigenic peptides displayed on highly polymorphic HLA (human leukocyte antigen)-II. Immunogenicity individual is largely unknown Only 1 HLA-II-restricted epitope was validated using the DRB1*07:01-APOB 3036 –3050 tetramer. We hypothesized that human may contain discrete immunodominant epitopes trigger...
Olfactory receptor 2 (Olfr2) has been identified in a minimum of 30% vascular macrophages, and its depletion was shown to reduce atherosclerosis progression. Mononuclear phagocytes, including monocytes macrophages within the vessel wall, are major players atherosclerosis. Single-cell RNA sequencing studies revealed that atherosclerotic artery walls encompass several defining at least nine distinct subsets potentially serving diverse functions disease This study investigates functional...
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose primary physiological function involves coordinating inflammatory and adaptive immune responses. However, uncontrolled TNF signaling causes aberrant inflammation has been implicated in several human ailments. Therefore, an understanding of the molecular mechanisms underlying dynamical gene controls bear significance for health. As such, engages canonical nuclear kappa B (NF-κB) pathway to activate RelA:p50 heterodimers, which induce...
Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), core protein most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive (ApoB + ) mostly regulatory (T regs ), which exert anti-inflammatory effects. Yet, they may obtain pro-inflammatory features and thus become proatherogenic. Evidence from animal studies suggests that vaccination against certain...
With the advancement in family planning practices and shifting norms from “hum do hamare do” to “one child,” there still exist mothers who are delivering their 10th children. Such an example is a woman residing urban slum Khordha district of Odisha, India. She has never used any modern methods contraception. Neither health workers that area could fulfill her unmet need for planning. The helpless mother missed all antenatal checkups as she did not have anyone accompany hospital. Three...
Anthrax is caused by Bacillus anthracis bacterium and an acute infectious febrile septicemic disease of all warm-blooded animals including human. It a major economic importance in ruminant specially goat characterized principally rapid fatal course followed sudden death. The present investigation was under taken to determine the biochemical characterization anthrax spore vaccine bacteria immunological response after vaccination. collected from local government veterinary hospital, Mymensingh...