A5054577697- NF-κB Signaling Pathways
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Thermodynamic properties of mixtures
- Cytokine Signaling Pathways and Interactions
- Spectroscopy and Quantum Chemical Studies
- Game Theory and Voting Systems
- Electrochemical Analysis and Applications
- Economic theories and models
- Cell death mechanisms and regulation
- Polymer Nanocomposites and Properties
- Immune cells in cancer
- Game Theory and Applications
- Immune responses and vaccinations
- Carbon Nanotubes in Composites
- Multiple Myeloma Research and Treatments
- Lightning and Electromagnetic Phenomena
- Nanopore and Nanochannel Transport Studies
- Surfactants and Colloidal Systems
- Rheology and Fluid Dynamics Studies
- Chemical and Physical Studies
- Immune Cell Function and Interaction
University of Maryland, Baltimore
2024
Indian Institute of Science Bangalore
2021-2023
National Institute of Immunology
2015-2021
Indian Institute of Technology Delhi
1998-2021
University of Calcutta
1953-2015
Significance The canonical NF-κB pathway mediates controlled nuclear activation of RelA factors, which induce proinflammatory genes. Uncontrolled activity, however, fuels aberrant intestinal inflammation. What triggers pathological activity in the colitogenic gut remains unclear. noncanonical module typically directs immune organogenesis involving Nfkb2 gene products. We find that this otherwise harmless signaling amplifies inflamed colon inflammatory bowel disease patients and mice,...
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without symptoms to acute respiratory distress and death. Empirical evidence points the prominent roles of innate immune CD8 T-cell responses determining outcomes. However, how these arms act concert elicit outcomes remains unclear. Here, we developed a mathematical model within-host that incorporates essential features responses. Remarkably, by varying strengths timings two arms, recapitulated entire spectrum realized....
Tissue microenvironment functions as an important determinant of the inflammatory response elicited by resident cells. Yet, underlying molecular mechanisms remain obscure. Our systems-level analyses identified a duration code that instructs stimulus specific crosstalk between TLR4-activated canonical NF-κB pathway and lymphotoxin-β receptor (LTβR) induced non-canonical signaling. Indeed, LTβR costimulation synergistically enhanced late RelA/NF-κB to TLR4 prolonging target gene-expressions....
In this paper, we consider a finite n-person non cooperative game. A non-linear optimization model is formulated in space of dimension equal to sum the total number pure strategies game and players. Nash equilibrium given shown be equivalent an optimal solution with zero value. The algorithm coded MATLAB using sequential quadratic programming based quasi Newton technique. To make user-friendly, GUI enabled software developed. Performance analyzed. Our computational experience has been very...
Environmental drug resistance constitutes a serious impediment for therapeutic intervention in multiple myeloma. Tumor-promoting cytokines, such as tumor necrosis factor (TNF), induce nuclear factor-κB (NFκB)- driven expression of pro-survival factors, which confer myeloma cells to apoptotic insults from TNF-related apoptosis-inducing ligand (TRAIL) and other chemotherapeutic drugs. It is thought that RelA:p50 dimer, activated IκBα-inhibited complex response TNF-induced canonical NFκB...
Macrophage-specific insulation of canonical NF-κB signaling from the noncanonical pathway prevents excessive inflammation.
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose primary physiological function involves coordinating inflammatory and adaptive immune responses. However, uncontrolled TNF signaling causes aberrant inflammation has been implicated in several human ailments. Therefore, an understanding of the molecular mechanisms underlying dynamical gene controls bear significance for health. As such, engages canonical nuclear kappa B (NF-κB) pathway to activate RelA:p50 heterodimers, which induce...
Abstract SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without symptoms to acute respiratory distress and death. While immunological correlates of disease severity have been identified, how they act together determine the outcomes is unknown. Here, using a new mathematical model within-host infection, we analyze diverse clinical datasets predict that subtle interplay between innate CD8 T-cell responses underlies heterogeneity. Our considers essential features these...
Accurate estimates of the prevalence asymptomatic SARS-CoV-2 infections, ψ, have been important for understanding and forecasting trajectory COVID-19 pandemic. Two-part population-based surveys, which test infection status also assess symptoms, used to estimate ψ. Here, we identified a widely prevalent confounding effect that compromises these devised formalism adjust it. The symptoms associated with are not all specific SARS-CoV-2. They can be triggered by host other conditions, such as...
Abstract The success of the live attenuated Yellow Fever vaccine (YF17D) that elicits immunity lasting over thirty years has made it a widely used model to understand generation durable protection. We compare early single-cell level transcriptional response in mice YF17D and an adjuvanted-inactivated, but less effective version (InYF). Within first week, we identify 70 kinetic patterns 45 cellular clusters, majority which discriminate between two formulations, some tissue sex-specific...
We report both the experimental and theoretical insights of differential electro-diffusion behavior carbon nanomaterials (e.g. single wall, multiwall nanotubes, graphene). thus discriminate one from other in a soft gel system. The mobility such material depends on their intrinsic properties, extend rate migration bearing discriminatory signature. analysis is made by real time monitoring respective bands.
Abstract By utilizing a static method, based on slight modification of the Wilhelmy plate interfacial properties one natural and two synthetic hymatomelanic acids were studied at both air–water oil–water interfaces. On this basis their number‐average molecular weights, flexibility shape macromolecular chains interface, related thermodynamic parameters evaluated.
ABSTRACT Unlike severe infections, asymptomatic infections occur independently of healthcare access and reflect the natural immunity to SARS-CoV-2. What determines their prevalence, ψ , its variation across nations is unknown. We conducted a systematic review serosurveys performed on samples representative national populations before vaccination emergence variants. The studies that met our selection criteria together sampled 4,58,489 individuals yielded estimates in 33 nations. Using...
Summary Stringent regulation of TNF signaling prevents aberrant inflammation. engages the canonical NF-κB pathway for activating RelA:p50 heterodimer, which mediates specific expressions pro-inflammatory and immune response genes. Importantly, system discriminates between time-varied inputs. Negative feedback regulators pathway, including IκBα, are thought to ensure transient responses brief stimulations. The noncanonical controls a separate RelB activity associated with differentiation. In...
Abstract Aberrant inflammation associated with human ailments, including inflammatory bowel disease (IBD), is typically fuelled by the inordinate activity of RelA/NF-κB transcription factors. As such, canonical NF-κB module mediates controlled nuclear activation RelA dimers from latent cytoplasmic complexes. What provokes pathological in colitogenic gut remains unclear. The noncanonical pathway promotes immune organogenesis involving Nfkb2 gene products. Because pathways are intertwined, we...