A5046418894- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Misinformation and Its Impacts
- Malaria Research and Control
- Vaccine Coverage and Hesitancy
- Advanced Chemical Sensor Technologies
- Birth, Development, and Health
- Immune responses and vaccinations
- Bacterial Identification and Susceptibility Testing
- Mosquito-borne diseases and control
- Mycorrhizal Fungi and Plant Interactions
- Single-cell and spatial transcriptomics
- Respiratory and Cough-Related Research
- Genital Health and Disease
- Legume Nitrogen Fixing Symbiosis
- Bacteriophages and microbial interactions
- Essential Oils and Antimicrobial Activity
- Microfluidic and Bio-sensing Technologies
- Plant-Microbe Interactions and Immunity
Makerere University
2019-2024
University of Maryland, Baltimore
2024
Infectious Diseases Institute
2021-2022
Uganda Cancer Institute
2021
Mulago Hospital
2021
National Institutes of Health
2021
Effective treatment of sexually transmitted infections (STIs) is limited by diagnostics that cannot deliver results rapidly while the patient still in clinic. The gold standard methods for identification STIs are nucleic acid amplification tests (NAATs), which too expensive widespread use and have lengthy turnaround times. To address need fast affordable diagnostics, we developed a portable, rapid, on-cartridge magnetofluidic purification testing (PROMPT) polymerase chain reaction (PCR)...
Abstract COVID-19 has greatly affected communities worldwide, more so in low- and middle-income countries. To successfully resolve the pandemic, vaccination coverage of than 80% is required. However, misinformation this by increasing vaccine hesitancy. Limited studies have assessed effect on acceptance, especially Africa. This study people’s knowledge uptake among healthcare workers (HCWs) versus general population Uganda. Methods was a cross-sectional quantitative conducted from January...
Background: The possible clinical application of specific cytokines and chemokines contributing to tumorigenesis the outcome several cancers has been reported. However, less invasive easily applicable biomarkers in prostate cancer diagnosis prognostication are still lacking. This study assessed levels plasma patients as potential for noninvasive early diagnosis. Methods: nine cytokines, IL-6, IL-8, IL-10, IL-1β, IL-17A, IL-2, M-CSF, IL-12 IFN-α, were detected by Luminex© liquid array-based...
Abstract Background Malaria is one of the most serious infectious diseases in world. The malaria burden greatly affected by human immunity, and immune responses vary between populations. Genetic diversity KIR HLA-C genes, which are important immunity to diseases, likely play a role this heterogeneity. Several studies have shown that genes influence response viral infections, but few examined infection, these used low-resolution genotyping. aim study was determine whether genetic variation...
Programmed death 1 (PD-1)/programmed death-ligand (PD-L1)-targeted immunotherapies have become a new mode of treatment for several tumours; however, there is limited evidence on the expression and prognostic value PD-1/PD-L1 in prostate cancer, especially African men.Plasma concentrations PD-L1/PD-1 were assessed using enzyme-linked immunosorbent assay patients with cancer normal healthy controls at Uganda Cancer Institute. The associations between plasma concentration levels serum...
Preeclampsia (PE) is a major cause of maternal and new-born morbidity mortality. Angiogenic factors contribute role in the vascular dysfunction associated with PE. We investigated circulating levels endothelial growth factor (VEGF), placental (PlGF) soluble Feline McDonough Sarcoma (fms)—like tyrosine kinase-1 (sFlt1), their association PE diagnostic performance disease among pregnant women Uganda. Using case-control study design, 106 normal pregnancy were enrolled. Demographic clinical...
Abstract The success of the live attenuated Yellow Fever vaccine (YF17D) that elicits immunity lasting over thirty years has made it a widely used model to understand generation durable protection. We compare early single-cell level transcriptional response in mice YF17D and an adjuvanted-inactivated, but less effective version (InYF). Within first week, we identify 70 kinetic patterns 45 cellular clusters, majority which discriminate between two formulations, some tissue sex-specific...
Aim: Cough due to Klebsiella pneumoniae and Streptococcus is currently managed by conventional antibiotics herbal extracts in Uganda. However, much as these are extensively used, their antibacterial activity not known. This study aimed at determining the of selected locally prepared cough against two bacterial strains i.e. (ATCC 700603), 49619).
 Methods: The were screened for using Agar-well diffusion method zone inhibition, macro broth dilution Minimum Inhibitory Concentration (MIC)...
Abstract Background: Malaria is one of the most serious infectious diseases in world. The malaria burden greatly affected by human immunity, and immune responses vary between populations. Genetic diversity KIR HLA-C genes, which are important immunity to diseases, likely play a role this heterogeneity. Several studies have shown that genes influence response viral infections, but few examined infection, these used low-resolution genotyping. aim study was determine whether genetic variation...
Abstract COVID-19 has greatly impacted communities worldwide, more so in developing countries. To successfully resolve the pandemic, vaccination coverage of than 80% is required. However, this been by misinformation that increased vaccine hesitancy. Limited studies have assessed effect on acceptance, especially Africa. This current understanding as well circulating uptake among healthcare workers (HCWs) versus general public (GP) Uganda. Methods: was a quantitative cross-sectional study...
Abstract Background: Malaria is one of the most serious infectious diseases in world. The malaria burden greatly affected by human immunity, and immune responses vary between populations. Genetic diversity KIR HLA-C genes, which are important immunity to diseases, likely play a role this heterogeneity. Several studies have shown that genes influence response viral infections, but few examined infection, these used low-resolution genotyping. Our aim was determine whether genetic variation...
<h3>Background</h3> Laboratory infrastructure is limited in Uganda; syndromic case management used to treat sexually transmitted infections (STI). Progress addressing the HIV epidemic threatened by uncontrolled STI transmission. We report on prevalence of Kampala, Uganda. <h3>Methods</h3> Demographic and behavioral data were captured questionnaire. Penile-meatal swabs, urine blood collected from Ugandan men with urethral discharge syndrome (UDS) attending 6 clinical sites Kampala Genital...
Preeclampsia (PE) is a major cause of maternal and new-born morbidity mortality. Angiogenic factors contribute role in the vascular dysfunction associated with PE. We investigated circulating levels endothelial growth factor (VEGF), placental (PlGF) soluble Feline McDonough Sarcoma (fms)-like tyrosine kinase-1 (sFlt1), their association PE diagnostic performance disease among pregnant women Uganda. Using case-control study design, 106 normal pregnancy were enrolled. Demographic clinical...
Abstract Background The programmed death 1 (PD1)/programmed death-ligand (PDL1) targeted immunotherapies have become a new mode of treatment for several tumours; however, there is limited evidence on the expression and prognostic value PD1/PDL1 in prostate cancer, especially African men. Methods plasma concentrations PD-L1/PD1 were assessed using Enzyme-Linked Immunosorbent Assay patients with cancer normal healthy controls at Uganda Cancer Institute. association between concentration levels...