A5040420064- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- HIV/AIDS Research and Interventions
- Microfluidic and Bio-sensing Technologies
- Genetics, Bioinformatics, and Biomedical Research
- Urinary Tract Infections Management
- HIV, Drug Use, Sexual Risk
- Biomedical and Engineering Education
- HIV-related health complications and treatments
- Pneumonia and Respiratory Infections
- HIV/AIDS drug development and treatment
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Biosimilars and Bioanalytical Methods
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Health and Medical Research Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
Infectious Diseases Institute
2019-2025
Makerere University
2020-2025
Effective treatment of sexually transmitted infections (STIs) is limited by diagnostics that cannot deliver results rapidly while the patient still in clinic. The gold standard methods for identification STIs are nucleic acid amplification tests (NAATs), which too expensive widespread use and have lengthy turnaround times. To address need fast affordable diagnostics, we developed a portable, rapid, on-cartridge magnetofluidic purification testing (PROMPT) polymerase chain reaction (PCR)...
Abstract Objectives Doxycycline post-exposure prophylaxis (doxycycline-PEP) can reduce incident cases of syphilis, chlamydia and possibly gonorrhoea especially among men who have sex with recent bacterial sexually transmitted infections (STIs). Owing to potential implementation doxycycline-PEP internationally, global tetracycline/doxycycline resistance data for contemporary Neisseria gonorrhoeae isolates has become imperative. We report tetracycline gonococcal (n = 2993) from eight WHO...
An urgent need exists for point-of-care diagnostics to detect tuberculosis (TB) among people with advanced human immunodeficiency virus (HIV) disease. The Fujifilm SILVAMP TB LAM (FujiLAM II) is a novel assay that detects mycobacterial lipoarabinomannan (LAM) antigen in the urine identify TB. We present validation of FujiLAM II on prospectively collected samples from outpatient adults HIV disease Uganda. performed prospective diagnostic accuracy study outpatients at 16 clinics was run...
The occurrence of chronic pulmonary aspergillosis (CPA) among drug sensitive tuberculosis (PTB) patients on optimal therapy with persistent symptoms was investigated.We consecutively enrolled participants PTB after 2 months anti-TB treatment at Mulago Hospital, Kampala, Uganda, between July 2020 and June 2021. CPA defined as a positive Aspergillus-specific IgG/IgM immunochromatographic test (ICT), cavity or without fungal ball chest X-ray (CXR), compatible >3 months.We 162 (median age 30...
Background Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant is recognized, extent its largely unknown. In 2016, World Health Organization’s Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated Uganda monitor trends. Objective This study characterizes and...
Objectives The emergence of multidrug-resistant Neisseria gonorrhoeae (NG) is a major global health threat necessitating response and control measures. NG antimicrobial resistance (AMR) surveillance data from sub-Saharan countries exceedingly limited. This paper aims to describe the establishment, design implementation standardised quality-assured gonococcal programme susceptibility patterns cultured isolates in Kampala, Uganda. Methods From March 2018 September 2019, using WHO Enhanced...
Objective High prevalence of sexually transmitted infections (STIs) combined with poor antimicrobial stewardship are drivers STI resistance (AMR) especially in resource-limited settings where syndromic case management (SCM) is the norm. We characterized patterns antibiotic use prior to clinic attendance and study enrollment Ugandan men urethral discharge syndrome (UDS), evaluated in-clinic prescribing, performance characteristics SCM. Methods Participants were recruited from government...
Invasive pulmonary aspergillosis is known to complicate the coronavirus diseases-2019 (COVID-19), especially those with critical illness. We investigated baseline anti-Aspergillus antibody serostatus of patients moderate-critical COVID-19 hospitalized at 3 Treatment Units in Uganda. All 46 tested patients, mean age 30, and 11% underlying respiratory disease had a negative serum IgM/IgG immunochromatographic test on day (mean) symptom onset (range 1-26), but follow up specimens assess...
Background Sexually transmitted infections (STIs) are a global health challenge. Testing is not routinely performed in low- and middle-income countries (LMICs), which bear disproportionate burden of STIs. Self-collected penile-meatal swabs (SCPMS) an alternative to urine for STI testing, but data from LMICs limited. Methods Between October 2019 September 2020, recruited participants with urethral discharge syndrome at government facilities Kampala, Uganda, provided SCPMS. Samples were...
Background Sexually Transmitted Infections (STIs) rank in the top 5 disease categories for which adults developing countries seek healthcare services. Community pharmacies offer clients convenience, proximity, extended opening hours, privacy, and efficiency, could make them desirable locations HIV STI screening treatment. We examined feasibility of using point-of-care (POC) tests other STIs at community pharmacies. Methods conducted a prospective cohort study persons seeking medication...
Research and clinical use of pharmacology laboratories are limited in low- middle-income countries. We describe our experience building sustaining laboratory capacity for at the Infectious Diseases Institute, Kampala, Uganda.Existing infrastructure was repurposed, new equipment acquired. Laboratory personnel were hired trained to optimise, validate, develop in-house methods testing antiretroviral, anti-tuberculosis other drugs, including 10 high-performance liquid chromatography four mass...
<sec> <title>BACKGROUND</title> Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant is recognized, extent its largely unknown. In 2016, World Health Organization’s Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated Uganda monitor trends. </sec>...
<h3>Background</h3> Multi-drug resistant Neisseria gonorrhoeae (NG) threatens the effectiveness of gonorrhea treatment and control globally. Pharyngeal NG (pNG) infections are hypothesized to play a role in emergence antimicrobial resistance (AMR) NG, yet epidemiology pNG is poorly understood, especially resource-limited settings (RLS). We report on men with concurrent urogenital Kampala, Uganda. <h3>Methods</h3> Penile-meatal pharyngeal samples were collected from Ugandan urethral discharge...