A5056463169- Acute Ischemic Stroke Management
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Cerebral Venous Sinus Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Nail Diseases and Treatments
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Traumatic Brain Injury and Neurovascular Disturbances
- Statistical Methods in Clinical Trials
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Optimal Experimental Design Methods
- Intracranial Aneurysms: Treatment and Complications
- Meta-analysis and systematic reviews
- Phytoplasmas and Hemiptera pathogens
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hospital Admissions and Outcomes
- HIV/AIDS oral health manifestations
- Advanced Statistical Methods and Models
- Radiation Dose and Imaging
- S100 Proteins and Annexins
University of Minnesota
2023-2025
University of Minnesota Medical Center
2025
University of Minnesota System
2023
Eli Lilly (United States)
2022-2023
University of Iowa Hospitals and Clinics
2019-2020
University of Iowa
2018-2020
China University of Political Science and Law
2020
Carver Bible College
2020
University of Iowa Health Care
2019
Abstract Background Amphotericin B is the gold standard treatment for severe mycoses. A new orally delivered, less-toxic formulation of amphotericin has been developed. Methods In our randomized clinical trial, we tested oral lipid nanocrystal (LNC) (MAT2203, Matinas Biopharma) vs intravenous (IV) human immunodeficiency virus–associated cryptococcal meningitis in 4 sequential cohorts. Two pilot cohorts assessed safety and tolerability (n = 10 each), 2 efficacy with/without IV loading doses...
OBJECTIVE Tirzepatide is a novel single-molecule glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, which demonstrated unprecedented improvements in glycemic control and body weight reduction, the SURPASS phase 3 program. In this exploratory analysis, we aimed to characterize tirzepatide-treated participants who achieved HbA1c <5.7% evaluate changes clinical markers associated with long-term cardiometabolic health. RESEARCH DESIGN AND METHODS...
Cross-validation is the most common way of selecting tuning parameters in penalized regression, but its use Cox regression models has received relatively little attention literature. Due to partial likelihood construction, carrying out cross-validation for not straightforward, and there are several potential approaches implementation. Here, we propose a new approach based on cross-validating linear predictors model compare it that have been proposed elsewhere. We show offers an attractive...
Abstract Background Neurocognitive impairment in HIV-associated cryptococcal meningitis survivors remains poorly characterized. We sought to identify risk factors associated with sustained neurocognitive impairment. Methods Cryptococcal from the ASTRO-CM trial underwent assessment at 12 weeks. A composite quantitative performance score (QNPZ-8) was calculated as a mean of 8 independent z-scores. Participants were classified by QNPZ-8 having mild (QNPZ-8 ≥−1), moderate (−2 < –1), or...
An urgent need exists for point-of-care diagnostics to detect tuberculosis (TB) among people with advanced human immunodeficiency virus (HIV) disease. The Fujifilm SILVAMP TB LAM (FujiLAM II) is a novel assay that detects mycobacterial lipoarabinomannan (LAM) antigen in the urine identify TB. We present validation of FujiLAM II on prospectively collected samples from outpatient adults HIV disease Uganda. performed prospective diagnostic accuracy study outpatients at 16 clinics was run...
While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively, prevalence, natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis (ISBAS) remain unknown.We reviewed our prospective institutional database to identify patients with ≥50% (BA) without significant burden in vertebral or cerebral arteries. Stroke mechanism, collateral circulation, degree length were analysed. The primary outcome was time from...
In sub-Saharan Africa, an estimated 25% of people with HIV present advanced and are at high risk opportunistic infections. Whereas histoplasmosis has occasionally been seen in Uganda, the understanding local acute infection is limited. We sought to determine prevalence Histoplasma antigenuria using enzyme immunoassay (EIA, clarus GM EIA, IMMY; Norman, OK, USA) a cohort outpatients disease Kampala, Uganda. Among persons positive urine antigen tests, we assessed their clinical presentation...
Abstract Background The EnACT trial was a phase 2 randomized clinical conducted in Uganda, which evaluated novel orally delivered lipid nanocrystal (LNC) amphotericin B combination with flucytosine for the treatment of cryptococcal meningitis. When (5FC) is used as monotherapy cryptococcosis, 5FC can induce resistant Cryptococcus mutants. Oral uses drug delivery mechanism, and we assessed whether resistance to develops during oral LNC–amphotericin therapy. Methods We enrolled Ugandans HIV...
Limited data exist on the antifungal activity of daily liposomal amphotericin B with flucytosine induction regimens for cryptococcal meningitis, which are recommended in high-income countries. Liposomal monotherapy at 3 mg/kg previously failed to meet noninferiority criteria compared deoxycholate its registrational clinical trial. We aimed compare quantitative and mortality between among persons human immunodeficiency virus (HIV)-related meningitis receiving adjunctive 100 mg/kg/day....
Cryptococcal meningitis is a leading cause of AIDS-related mortality. antigen (CrAg) predicts the development meningitis. Historically, despite standard- of-care fluconazole, 25%-30% asymptomatic CrAg-positive persons develop breakthrough or death. We evaluated whether adding single high-dose liposomal amphotericin B to standard pre-emptive fluconazole therapy could improve meningitis-free survival. Participants with human immunodeficiency virus (HIV) and cryptococcal antigenemia in Uganda...
The Visitect CD4 Advanced Disease test (AccuBio, Alva, United Kingdom) is a rapid, semi-quantitative assay that estimates results above or below 200 cells/μL. We evaluated the performance of in semi-urban laboratories Uganda.
Abstract Background In 2022, the World Health Organization (WHO) recommended a single 10 mg/kg dose of liposomal amphotericin B in combination with 14 days flucytosine and fluconazole (AMBITION-cm regimen) for induction therapy human immunodeficiency virus (HIV)-associated cryptococcal meningitis, based on results multisite AMBITION-cm trial. We evaluated outcomes after real-world implementation this novel regimen Uganda. Methods enrolled Ugandan adults meningitis into an observational...
Return-to-baseline is an important method to impute missing values or unobserved potential outcomes when certain hypothetical strategies are used handle intercurrent events in clinical trials. Current return-to-baseline approaches seen literature and practice inflate the variability of "complete" dataset after imputation lead biased mean estimators probability missingness depends on observed baseline and/or postbaseline intermediate outcomes. In this article, we first provide a set criteria...
Cross validation is commonly used for selecting tuning parameters in penalized regression, but its use Cox regression models has received relatively little attention the literature. Due to partial likelihood construction, carrying out cross not straightforward, and there are several potential approaches implementation. Here, we propose two new cross-validation methods compare them that have been proposed elsewhere. Our approach of cross-validating linear predictors seems offer an attractive...
We investigated cerebrospinal fluid (CSF) host transcriptomic differences in TBM survivors compared to non-survivors as a means of understanding the role that response plays surviving
Abstract Background Persons with HIV and cryptococcal antigenemia are at high risk of progression to meningitis or death. Baseline antigen (CrAg) plasma titer ≥1:160 is a known factor for poor outcomes, but other factors unknown. In HIV-associated meningitis, baseline serum C-reactive protein (CRP) concentrations positively associated increased mortality. We hypothesized that CRP might also be death in persons antigenemia. Methods measured CrAg titers on cryopreserved from prospectively...
Objective: To study the operative method, special technique and curative effect of complete neuroendoscopic microvascular decompression(MVD) related to vertebrobasilar artery compression. Methods: Thirteen patients with functional cranial nerve disease caused by as direct or indirect responsible vessel accepted endoscopic MVD, including 11 hemifacial spasm 2 trigeminal neuralgia. The procedure surgery were analyzed retrospectively. Results: All procedures MVD successfully...