A5034244077- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS oral health manifestations
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Diagnosis and treatment of tuberculosis
- Gut microbiota and health
- Probiotics and Fermented Foods
- Urinary Tract Infections Management
- Plant Pathogens and Fungal Diseases
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Nail Diseases and Treatments
- Infectious Diseases and Tuberculosis
- Viral Infections and Outbreaks Research
- Neutropenia and Cancer Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Milk Quality and Mastitis in Dairy Cows
- Oral microbiology and periodontitis research
- SARS-CoV-2 and COVID-19 Research
- Berberine and alkaloids research
- Insect symbiosis and bacterial influences
Makerere University
2015-2025
Kabale University
2024
Busitema University
2024
Infectious Diseases Institute
2021-2024
Muni University
2024
Lung Institute
2023
University of Agriculture Faisalabad
2022
Gulu University
2021
Newcastle University
2015
ABSTRACT Cryptococcal antigen screening is recommended among people living with AIDS when entering HIV care a CD4 count of <100 cells/μl, and preemptive fluconazole monotherapy treatment for those subclinical cryptococcal antigenemia. Yet, knowledge limited current antimicrobial resistance in Africa. We examined antifungal drug susceptibility 198 clinical isolates collected from Kampala, Uganda, between 2010 2014 using the CLSI broth microdilution assay. In comparison two previous studies...
Background: Urinary tract infections (UTI) are a common medical problem affecting the general population and thus commonly encountered in practice, with global burden of UTIs at about 150 million people. Because uropathogens largely originate from colonic flora, they easy to predict, this is rationale for empirical treatment Community Acquired-UTI (CA-UTIs). With increasing prevalence drug-resistant bacteria among adults CA-UTI Uganda, it no longer adequate manage CA-UTIs on empiric regimen...
Abstract Background Mixed M. tuberculosis (MTB) infection occurs when one is infected with more than clonally distinct MTB strain. This form of can assist strains to acquire additional mutations, facilitate the spread drug-resistant strains, and boost rate treatment failure. Hence, presence mixed could affect performance some rapid molecular diagnostic tests such as Line Probe Assay (LPA) GeneXpert MTB/RIF (Xpert) assays. Methods was a cross-sectional study that used sputum specimens...
Postgraduate medical mycology research may also be affected by funding. This study reports the positive impact of funding on postgraduate at Makerere University, Uganda. retrospective was conducted microbiology dissertation topics from 2023 to 2024 using data collected between September and November 2024. A total N = 60 dissertations were analyzed for topics, which a 18 (30%) focused mycology. The percentage centered increased 16% (four 25) in 40% (14 35) Cryptococcal meningitis is most...
Background The drastic rise of antimicrobial resistance to alarming states is one the major concerns global health today. overuse antibiotics in animal husbandry has tremendously contributed increased emergence resistant bacteria. These strains from animals can be transferred humans through food chain like raw milk which a potential source food-borne bacterial pathogens including E. coli. Objective objective this study was compare patterns antibacterial coli isolates origin samples and...
ABSTRACT Hospital-acquired infections caused by multidrug-resistant Klebsiella pneumoniae are steadily increasing worldwide. Here, we report complete genome sequences of colistin-resistant K. isolates from rectal swab samples intensive care unit (ICU) patients. Genome size in each strain varied with mean 5,335,766 bp and GC content averaging 57.48%.
Background. Klebsiella pneumoniae is part of the ESKAPE (Enterococcus faecium, Staphylococcus aureus, pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp) group MDR pathogens. It second leading cause nosocomial bloodstream infections, it has a propensity to be drug resistant. Therefore, was aimed determine antibiotic resistance patterns K. isolated from blood cultures patients with features sepsis at Mulago National Referral Hospital, Uganda. Methods The...
Background.Klebsiella pneumoniae is part of the ESKAPE (Enterococcus faecium, Staphylococcus aureus, K. pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) group multidrug-resistant (MDR) pathogens. leading cause antimicrobial resistance-associated mortality second nosocomial bloodstream infections (BSIs), globally in sub-Saharan Africa. Therefore, it was aimed to determine antibiotic resistance patterns isolated from blood cultures patients with features...
Background: Pulmonary mycoses are important diseases of the respiratory tract caused by pulmonary fungal pathogens. These pathogens responsible for significant morbidity and mortality rates worldwide; however, less attention has been paid to them. In this study we determined prevalence among individuals with clinical features tuberculosis at Mbarara Regional Referral Hospital. Method: This was a hospital based cross sectional survey. Sputum samples were collected from each participant. For...
Background: Despite the increased frequency of oropharyngeal candidiasis among people living with human immunodeficiency virus (HIV), its management is no longer effective due to empirical treatment and emergence antifungal resistance (AFR). This study sought investigate prevalence assess susceptibility profile Candida species isolated from virus. Additionally, we evaluated correlation between CD4 T cell as well viral load counts. Methods: A descriptive cross-sectional was carried out April...
Accurate and high-throughput genotyping of Mycobacterium tuberculosis complex (MTBC) may be important for understanding the epidemiology pathogenesis (TB). In this study, we report development a LightCycler® real-time PCR single-nucleotide-polymorphism (LRPS) assay rapid determination MTBC lineages/sublineages in minimally processed sputum samples from TB patients.Genotyping analysis 70 strains was performed using Long Sequence Polymorphism-PCR (LSP-PCR) technique LRPS parallel. For targeted...
Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms microbiome interactions are poorly understood. Understanding how environmental microbes, such as fungi bacteria, coevolve develop traits to evade host immune responses resist treatment is critical controlling opportunistic fungal coinfections. In this project, we propose study coexistence bacterial microbial...
Background Dental caries is a multifactorial disease that affects many people. Even though microorganisms play crucial role in causing dental caries, diagnosis routinely macroscopic. In order to improve early detection especially HIV patients who are disproportionately affected, there need reconcile the macroscopic and microscopic characteristics of caries. Therefore, aim this study was characterize oral microbiota profile along decayed, missing, filled teeth (DMFT) index using amplicon...
Invasive pulmonary aspergillosis is known to complicate the coronavirus diseases-2019 (COVID-19), especially those with critical illness. We investigated baseline anti-Aspergillus antibody serostatus of patients moderate-critical COVID-19 hospitalized at 3 Treatment Units in Uganda. All 46 tested patients, mean age 30, and 11% underlying respiratory disease had a negative serum IgM/IgG immunochromatographic test on day (mean) symptom onset (range 1-26), but follow up specimens assess...
Introduction. Drug resistant tuberculosis remains a worldwide problem that requires prompt diagnosis.Hypothesis/Gap statement. The WHO recommended direct, rapid Xpert MTB/RIF is prohibitively costly, therefore, there need to validate rapid, affordable DST for use in low- and middle-income settings.Aim. technical performance time results of simple, direct microscopy-based slide (SDST) assay diagnosis rifampicin-resistant TB was evaluated Uganda.Methodology. Sputum samples from 122...
Klebsiella pneumoniae is a leading cause of healthcare acquired infections. The severity the infections multifactorial including virulence and antimicrobial resistance properties. objective study was to investigate determinants K. strains colonizing patients hospitalized in intensive care units (ICU) tertiary hospital Uganda. A based cross-sectional involving 103 admitted ICU Mulago National Referral conducted from January 2022 April 2022. total 31 identified clinical isolated rectal swabs...
Abstract Introduction Dimorphic fungi cause infection following the inhalation of spores into pulmonary system. In lower respiratory tract, conidia transform yeasts, which are engulfed by alveolar macrophages and may be destroyed without disease manifestation. However, in some immunocompromised individuals, they persist active fungal characterized formation granulomas infected tissues, mimic Mycobacterium tuberculosis (MTB). Objective To determine prevalence dimorphic infections among...
Oropharyngeal