A5064199100- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Syphilis Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Reproductive tract infections research
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- ICT in Developing Communities
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent and Pediatric Healthcare
- Antifungal resistance and susceptibility
- Healthcare Systems and Reforms
- Fungal Infections and Studies
- Liver Disease Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Ethics in Clinical Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Migration, Health and Trauma
Makerere University
2016-2025
Infectious Diseases Institute
2016-2025
University of Cambridge
2018-2024
University of Buea
2023
Uganda Virus Research Institute
2009-2017
Mulago Hospital
2015-2017
Johns Hopkins University
2016
Liverpool School of Tropical Medicine
2009-2014
University of Bahrain
2014
Imperial College London
2010-2011
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy sub-Saharan Africa. Patients typically attend clinics every 1 3 months for clinical assessment. The clinic costs comparable with the of drugs themselves and CD4 counts measured 6 months, but rarely switched second-line therapies. To ensure sustainability treatment programmes, a transition more cost-effective delivery is needed. In contrast count, measurement level HIV RNA plasma (the viral load)...
Introduction Alcohol use by persons living with HIV/AIDS (PLWHA) negatively impacts the public health benefits of antiretroviral therapy (ART). Using a standardized alcohol assessment tool, we estimate prevalence use, identify associated factors, and test association misuse sexual risk behaviors among PLWHA in Uganda. Methods A cross-section Kampala were interviewed regarding their behavior self-reported consumption previous 6 months. was assessed using disorders identification (AUDIT)....
Cryptococcal disease remains an important cause of morbidity and mortality in HIV-infected individuals sub-Saharan Africa, despite the introduction antiretroviral therapy. We studied fluconazole as primary prophylaxis against cryptococcal patients awaiting or starting therapy Uganda.In this prospective, double-blind randomised controlled trial, we enrolled HIV-positive adults with CD4 counts less than 200 cells per μL, antigen (CrAg)-negative, naive for therapy, coming from five local AIDS...
We evaluated the efficacy of a brief motivational intervention (MI) counseling in reducing alcohol consumption among persons living with HIV/AIDS Kampala, Uganda. Persons Alcohol Use Disorders Identification Tool (AUDIT) score ≥3 points were randomized to either standardized positive prevention alone or combination MI counseling. The mean change AUDIT-C scores over 6 months was compared by treatment arm. (standard deviation [SD]) 6.3 (2.3) and 6.8 for control arms ( P = .1) at baseline,...
Abstract Background Throughout the last decade, tuberculosis (TB) treatment success has not surpassed 90%, global target. The impact of mobile health interventions (MHIs) on TB outcomes is unknown, especially in low- and middle-income countries (LMICs). MHIs, including interactive voice response technology (IVRT), may enhance adherence retention care patients with improve outcomes. This study seeks to determine IVRT-based MHI (treatment completion cure rates) receiving at five public...
Promoting healthy ageing would benefit from an understanding of what this means to stakeholders. We explored perceptions in rural and peri-urban Ugandan communities. Community dialogues, focus group discussions with older persons, community members, community-based organization leaders, key informant interviews Ministries Gender (2), Health (1), non-governmental organizations (3) elderly representatives (5) were held. Thematic content analysis framework was used. Physical included physical...
Purpose: This study aimed to measure symptom burden prior antiretroviral therapy (ART) initiation in a population of adults with low CD4 presenting for human immunodeficiency virus (HIV) care and treatment Uganda, explore the relationship between World Health Organization (WHO) stage, count, symptomatology. Methods: HIV-infected, ART-naïve less than 200 cells per microliter referred from voluntary testing counseling services rural Uganda potential enrollment into large double-blinded...
Adherence to treatment is critical for successful outcomes. Although factors influencing antiretroviral therapy (ART) adherence vary, young adults are less likely adhere owing psychosocial issues such as stigma, ART-related side effects, and a lack of access treatment. The Call Life Uganda (CFLU) mobile health (mHealth) tool phone-based technology that provides text messages or interactive voice response functionalities through web interface offers 4 modules support.This study aims describe...
Following the successful scale-up of antiretroviral therapy (ART), focus is now on ensuring good quality life (QoL) and sustained viral suppression in people living with HIV. The access to mobile technology most burdened countries increasing rapidly, therefore, health (mHealth) technologies could be leveraged improve QoL However, data impact mHealth tools HIV are limited evaluation SMS text messaging; these infeasible high-illiteracy settings.The primary secondary outcomes were determine...
The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsible for significant mortality in patients treated Uganda.We retrieved tested paired serum aliquots 101 HIV-TB co-infected at the beginning week 24 TB treatment. We samples Aspergillus-specific immunoglobulin G (IgG) E (IgE) using ImmunoCAP®; IgG total IgE Immulite® immunoassays....
Introduction The effect of long-term exposure to antiretroviral therapy (ART) on hypertension in sub-Saharan Africa remains unclear. We aimed determine the prevalence and incidence people living with HIV (PLWH) more than 10 years ART Uganda. Methods analysis was performed within a cohort adult PLWH at an clinic Kampala, Participants were eligible for this if they had ≥2 follow-up visits. Hypertension defined as two consecutive systolic blood pressure (SBP) measures greater 140 mmHg and/or...
Syphilis infection during pregnancy leads to avoidable morbidity and mortality remains a significant problem in sub-Saharan Africa. Despite global initiatives increase the proportion of pregnant women screened, implementation has been slow. We sought investigate feasibility adding syphilis screening within an integrated antenatal HIV clinic. Pregnant attending clinic were sequentially enrolled consenting participants answered questionnaire on sexual behavior previous pregnancies, provided...
Whilst multi-lateral funding for HIV/AIDS dramatically increased from 2004 to 2008, it has largely plateaued in the last 8 years. Across sub-Saharan Africa, up 20 % of total spending on health is used HIV services, and this over 85 estimated come international rather than in-country sources. In Uganda, fiscal liability maintain services all those who are currently receiving be as much 3 Gross Domestic Product (GDP). order meet growing need patient numbers further ART coverage projected costs...
Early diagnosis of HIV associated lymphoma is challenging because the definitive diagnostic procedure biopsy, requires skills and equipment that are not readily available. As a consequence, may be delayed increasing risk mortality. We set out to determine frequency factors with misdiagnosis as tuberculosis (TB) among patients attending Uganda Cancer Institute (UCI).A retrospective cohort study design was used UCI, Kampala, between February March 2015. Eligible patient charts were reviewed...
Background Maternal syphilis causes poor birth outcomes, including congenital syphilis. Testing and treatment of partners prevents reinfection, but strategies to improve partner attendance are failing. The aim this study was determine the effectiveness three notification strategies. Methods: Pregnant women with a positive point-of-care treponemal test at antenatal clinics (ANCs) in Kampala, Uganda, were randomised 1:1:1 receive either slips (NS; standard care), NS text messages (SMS) or...
There have been 3 outbreaks of viral hemorrhagic fever (VHF) in Uganda the last 2 years. VHF often starts with non-specific symptoms prior to onset haemorrhagic signs. HIV clinics outbreak countries such as see large numbers patients 1/2 infection presenting every day. Whilst there are good screening tools for general health care facilities expecting suspects, we were unable find use or other non-acute clinics.We designed help communication staff, control and a clinic during Uganda. We...
Persons living in refugee settlements sub-Saharan Africa may be at increased risk for COVID-19 and experience barriers to accessing information. We aimed evaluate the implementation of "Dial-COVID" a multi-lingual, toll free, telephone platform that uses interactive voice response (IVR) track symptoms/exposure disseminate health information Uganda. hypothesized IVR could provide an alternative way screen communicate public humanitarian populations when physical access testing capacity were...
Objective Despite expanding access to antiretroviral therapy (ART) in Sub-Saharan Africa, there are few data on patients' perceptions about starting ART explore issues affecting decisions start eligible individuals during the roll out. Methods We studied patterns of uptake for 957 participants a trial cryptococcal disease prevention and performed qualitative cross-sectional study this cohort. In-depth interviews (IDIs) were conducted with 48 who started after variable time trial. Results...
Scale-up of HIV services in sub-Saharan Africa has rapidly increased, necessitating evaluation medication safety these settings. Drug-drug interactions (DDIs) involving antiretrovirals (ARVs) are poorly characterized. We evaluated the prevalence and type ARV DDIs Ugandan outpatients identified patients most at risk.A total 2000 consecutive receiving ARVs Infectious Diseases Institute, Kampala were studied. The recent prescription for each patient was screened clinically significant using...
Introduction: Anemia is a common problem in HIV sub-Saharan Africa. We describe the contribution of antiretroviral therapy (ART) regimen to incidence anemia and changes hemoglobin (Hb) HIV-infected patients Uganda. Methods: This study was nested prevention cryptococcal disease trial (CRYPTOPRO; ISCRTN7648152). Patients received 3 different backbones nucleoside reverse transcriptase inhibitor nonrandomized manner. Results: Of 852 (161 on zidovudine [ZDV], 628 stavudine [d4T], 63 tenofovir...
We conducted a retrospective cohort study to assess the effect of tracking People Living with HIV (PLHIV) after missed clinic visits and factors associated return care in rural Uganda. assessed retention among 650 HIV-infected women men. used univariable multivariable generalized linear models demographic self-reported re-engagement care. Of 381 PLHIV who ever scheduled appointment, 68% were female most (80%) had initiated ART. Most (70%) those tracked returned Relative men, (adjusted risk...
Syphilis screening can be successfully integrated into antenatal clinics, and potentially avert significant morbidity mortality to unborn infants. A minority of male partners report for testing treatment, increasing the likelihood reinfection. We conducted a qualitative study understand factors influencing seek treatment after syphilis notification by their pregnant partners. purposeful sample 54 adults who participated in STOP (Syphilis Treatment Partners) was stratified gender (24 women,...