A5032992537- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Medication Adherence and Compliance
- HIV Research and Treatment
- Pharmaceutical Practices and Patient Outcomes
- HIV-related health complications and treatments
- Hepatitis C virus research
- Computational Drug Discovery Methods
- Pregnancy and Medication Impact
- Pharmaceutical Economics and Policy
- Bipolar Disorder and Treatment
- Inflammatory mediators and NSAID effects
- Research on Leishmaniasis Studies
- Pharmacogenetics and Drug Metabolism
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- Healthcare Quality and Management
- HIV, Drug Use, Sexual Risk
- Healthcare Systems and Reforms
- Biochemical and Molecular Research
- HIV/AIDS Impact and Responses
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
University of Liverpool
2012-2024
Makerere University
2018
Infectious Diseases Institute
2018
Chelsea and Westminster Hospital
2017
Royal Liverpool and Broadgreen University Hospital NHS Trust
2009-2013
Royal Liverpool University Hospital
2011
To evaluate the prevalence, type and severity of prescribing errors observed between grades prescriber, ward area, admission or discharge medication prescribed.Ward-based clinical pharmacists prospectively documented at point clinically checking prescriptions. Error categories severities were assigned data collection, verified independently by study team.Prospective nine diverse National Health Service hospitals in North West England, including teaching hospitals, district specialist...
BackgroundLate initiation of antiretrovirals in pregnancy is associated with increased risk perinatal transmission and higher infant mortality. We report the final 72-week postpartum results for efficacy safety dolutegravir-based compared efavirenz-based regimens mothers infants.MethodsDolPHIN-2 was a randomised, open-label trial. Pregnant women South Africa Uganda aged at least 18 years, untreated but confirmed HIV infection an estimated gestation 28 weeks, initiating antiretroviral therapy...
Recent advances in the development of agents that act specifically to inhibit hepatitis C virus (HCV) are set fundamentally change way patients will be treated. New directly acting anti-HCV such as protease and polymerase inhibitors initially added standard care with pegylated interferon-α ribavirin. However, future therapy is likely constitute combinations which at distinct stages viral replication have differing resistance profiles. While undoubtedly improve treatment outcomes,...
Background Clinically significant drug-drug interactions (CSDIs) involving antiretrovirals are frequent and under-recognized in developed countries, but data lacking for developing countries. Methodology Principal Findings To investigate the prevalence of CSDIs between coadministered drugs, we surveyed prescriptions dispensed a large HIV clinic Kenya. Of 1040 consecutive patients screened, 996 were eligible inclusion. defined as 'major' (capable causing severe or permanent damage,...
In 2019, the World Health Organisation (WHO) recommended Dolutegravir (DTG) as preferred first-line antiretroviral treatment (ART) for all persons with HIV. ART regimen switches may affect HIV adherence. We sought to describe patient experiences switching from EFV DTG-based in Kampala, Uganda.Between July and September we purposively sampled adults living who had switched DTG at Infectious Diseases Institute clinic. conducted in-depth interviews DTG, explore their preparation switch on DTG....
These guidelines are dedicated to the memory of Professor Stephen Lawn, a scientist and clinician whose pioneering work helped transform management TB in people living with HIV. The overall purpose these is help physicians manage adults tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection. Recommendations for treatment HIV-positive similar those HIV-negative adults. Of note, term "HIV" refers HIV-1 throughout guidelines. British HIV Association (BHIVA) fully revised updated...
Scale-up of HIV services in sub-Saharan Africa has rapidly increased, necessitating evaluation medication safety these settings. Drug-drug interactions (DDIs) involving antiretrovirals (ARVs) are poorly characterized. We evaluated the prevalence and type ARV DDIs Ugandan outpatients identified patients most at risk.A total 2000 consecutive receiving ARVs Infectious Diseases Institute, Kampala were studied. The recent prescription for each patient was screened clinically significant using...
Drug-drug interactions between antiretroviral therapy and other drugs are well described. Gastric acid-reducing agents one such class. However, few data exist regarding the frequency of indications for prescription, nor risk assessment in setting an HIV cohort receiving therapy. To assess prevalence prescription gastric drug-drug interaction within a UK cohort, we reviewed patient records whole assessing demographic data, reason Furthermore, noted potential whether had been documented...
Antiretroviral therapy (ART) is complex and has high propensity for medication error drug-drug interactions (DDIs). We evaluated the clinical utility of pharmacist prescreening DDIs, adherence to ART medicines reconciliation prior HIV outpatient appointments. A took detailed histories assessments, then screened DDIs. template detailing current medication, potential DDIs was filed in notes physicians were asked structured feedback. Potential observed 58% 200 patients, with 22 (9%) occurring...
Efavirenz-related nervous system or psychiatric adverse drug reactions (ADRs) are conventionally reported to resolve soon after initiation, with incidence of dizziness at 8.5% in large clinical trials. Patients black ethnicity genetically greater risk elevated efavirenz exposure, which has been linked toxicity. The current data derive from a prospective longitudinal observational study adult HIV-positive outpatients taking antiretrovirals, three diverse clinics central Uganda. As part an...
In many British hospitals, HIV-positive patients access care via genitourinary (GU) medicine services. As a result of National Health Service (NHS) legislation, such may have information concerning HIV treatment filed separately from their general clinical records. We sought to evaluate accuracy medication records with both GU and hospital case-notes, assess risk arising incorrect or incomplete recording. this retrospective review, 156 episodes 100 separate case-notes were evaluated for...
We investigated the impact of Drug-Drug Interactions (DDIs) on virologic control among HIV-positive pregnant women initiating antiretroviral therapy while identifying drivers for Traditional Medicine (TM) use and exploring nature extent TM-related DDIs.
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
Scale‐up of HIV services in countries such as Uganda has resulted a rapid increase facilities offering antiretrovirals (ARVs) and an healthcare workers trained to deliver care. Consequently, evaluating medication safety is increasingly important these settings. Data from developed suggest that drug‐drug interactions (DDIs) involving ARVs are common, occurring at rates 14–58%. Few data available low resource settings, however study 996 Kenyan patients found 33.5% were risk clinically...