A5012223514- Pregnancy and Medication Impact
- Pharmaceutical studies and practices
- Breastfeeding Practices and Influences
- HIV/AIDS drug development and treatment
- Malaria Research and Control
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug Transport and Resistance Mechanisms
- HIV-related health complications and treatments
- Reproductive Health and Contraception
- Tuberculosis Research and Epidemiology
- Pregnancy and preeclampsia studies
Makerere University
2023-2024
Infectious Diseases Institute
2023-2024
BackgroundLate initiation of antiretrovirals in pregnancy is associated with increased risk perinatal transmission and higher infant mortality. We report the final 72-week postpartum results for efficacy safety dolutegravir-based compared efavirenz-based regimens mothers infants.MethodsDolPHIN-2 was a randomised, open-label trial. Pregnant women South Africa Uganda aged at least 18 years, untreated but confirmed HIV infection an estimated gestation 28 weeks, initiating antiretroviral therapy...
<ns3:p><ns3:bold>Background: </ns3:bold>Data surrounding the exposure of breastfed infant to drugs and any associated risks are sparse. Drugs transferred milk in small quantities, many have been used without obviously noticeable toxicity for years – this lack a ‘safety signal’ has further reduced interest studying mother-to-infant transfer drugs. In sub-Saharan Africa, pregnant women at risk <ns3:italic>Plasmodium falciparum</ns3:italic> infection, one four evidence placental infection time...
Abstract Background Rapid reduction in human immunodeficiency virus (HIV) load is paramount to prevent peripartum transmission women diagnosed late pregnancy. We investigated dolutegravir population pharmacokinetics maternal plasma, umbilical cord, breast milk, and infant plasma samples from DolPHIN-1 participants (NCT02245022) presenting with untreated HIV pregnancy (28–36 weeks gestation). Methods Pregnant Uganda South Africa were randomized (1:1) daily (50 mg/d) or efavirenz-based...
<ns4:p>Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure breastfed infant to drugs and any related risks are sparce. Lactation studies only rarely performed close licensing for anticipated be widely used in childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can transferred infant. Potential effects anti-tuberculosis nursing infants not well understood. Similarly, face mental health challenges...
<ns4:p><ns4:bold>Background</ns4:bold></ns4:p><ns4:p> Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure breastfed infant to drugs and any related risks are sparce. Lactation studies only rarely performed close licensing for anticipated be widely used in childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can transferred infant. Potential effects anti-tuberculosis nursing infants not well understood....
<ns3:p>Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure breastfed infant to drugs and any related risks are sparce. Lactation studies only rarely performed close licensing for anticipated be widely used in childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can transferred infant. Potential effects anti-tuberculosis nursing infants not well understood. Similarly, face mental health challenges...
<ns4:p><ns4:bold>Background: </ns4:bold>Data surrounding the exposure of breastfed infant to drugs and any associated risks are sparse. Drugs usually transferred milk in small quantities, many have been used without obviously noticeable toxicity for years – this lack a ‘safety signal’ has further reduced interest studying mother-to-infant transfer drugs. In sub-Saharan Africa, pregnant women at risk <ns4:italic>Plasmodium falciparum</ns4:italic> infection, one four evidence placental...
<ns3:p>Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure breastfed infant to drugs and any related risks are sparce. Lactation studies only rarely performed close licensing for anticipated be widely used in childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can transferred infant. Potential effects anti-tuberculosis nursing infants not well understood. Similarly, face mental health challenges...