A5027581358- Global Maternal and Child Health
- Reproductive Health and Contraception
- Maternal and Perinatal Health Interventions
- Adolescent Sexual and Reproductive Health
- Maternal and fetal healthcare
- HIV/AIDS Research and Interventions
- Ureteral procedures and complications
- Pregnancy and preeclampsia studies
- Anorectal Disease Treatments and Outcomes
- Neonatal Respiratory Health Research
- Cervical Cancer and HPV Research
- Urological Disorders and Treatments
- Child Nutrition and Water Access
- Emergency and Acute Care Studies
- Pregnancy and Medication Impact
- Reproductive tract infections research
- Diverticular Disease and Complications
- HIV Research and Treatment
- Global Cancer Incidence and Screening
- HIV/AIDS drug development and treatment
- Neonatal and fetal brain pathology
- Global Health and Surgery
- Simulation-Based Education in Healthcare
- HIV/AIDS Impact and Responses
- Hepatitis B Virus Studies
Makerere University
2016-2025
Mulago Hospital
2014-2024
Mbarara University of Science and Technology
2023
Karolinska Institutet
2006-2022
Infectious Diseases Institute
2020
University of Alberta
2019
Arrowhead Regional Medical Center
2019
Royal Alexandra Hospital
2019
Juntendo University
2019
Royal College of Surgeons in Ireland
2019
High fertility among young people aged 15-24 years is a public health concern in Uganda. Unwanted pregnancy, unsafe induced abortions and associated high morbidity mortality women may be attributed to low contraceptive use. This study aims at exploring reasons for use people. In 16 focus group discussions, the views of about obstacles enabling factors Mityana Mubende districts, Uganda were explored. The groups homogeneously composed by married unmarried men women, between ages 15-24. data...
This study evaluates the feasibility and performance of careHPV, a novel human papillomavirus (HPV) DNA test, when used for screening women cervical cancer in low-resource settings.Clinician-collected (cervical) self-collected (vaginal) careHPV specimens, visual inspection with acetic acid (VIA), Papanicolaou test were evaluated among 16,951 eligible India, Nicaragua, Uganda. Women positive results received colposcopy histologic follow-up as indicated. The positivity each method was...
Postpartum hemorrhage is the most common cause of maternal death. Oxytocin standard therapy for prevention postpartum hemorrhage, but it requires cold storage, which not available in many countries. In a large trial, we compared novel formulation heat-stable carbetocin with oxytocin.We enrolled women across 23 sites 10 countries randomized, double-blind, noninferiority trial comparing intramuscular injections (at dose 100 μg) oxytocin IU) administered immediately after vaginal birth. Both...
In sub-Saharan Africans, maternal mortality is unacceptably high, with >400 deaths per 100,000 births compared <10 in Europeans. One-third of the are caused by pre-eclampsia, a syndrome arising from defective placentation. Controlling placentation natural killer (NK) cells that use killer-cell immunoglobulin-like receptor (KIR) to recognize fetal HLA-C molecules on invading trophoblast. We analyzed genetic polymorphisms KIR and 484 normal 254 pre-eclamptic pregnancies at Mulago Hospital,...
Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Contraception and Study using marginal structural modeling to reduce selection bias due time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased acquisition. Also, young (18-24 years) older women who DMPA COCs were at risk.
Unintended pregnancies lead to unsafe abortions, which are a leading cause of preventable maternal mortality among young women in Uganda. There is discrepancy between the desire prevent pregnancy and actual contraceptive use. Health care providers' perspectives on factors influencing use service provision people aged 15-24 two rural districts Uganda were explored. Semi-structured questionnaires used for face- to-face interviews with 102 providers at public, private not-for-profit, for-profit...
Background The global transition to use of dolutegravir (DTG) in WHO-preferred regimens for HIV treatment is limited by lack knowledge on pregnancy. Here we assessed the relationship between drug concentrations (pharmacokinetics, PK), including breastmilk, and impact viral suppression when initiated third trimester (T3). Methods findings In DolPHIN-1, HIV-infected treatment-naïve pregnant women (28–36 weeks gestation, age 26 (19–42), weight 67kg (45–119), all Black African) Uganda South...
Background Escalation in the global rates of labour interventions, particularly cesarean section and oxytocin augmentation, has renewed interest a better understanding natural progression. Methodological advancements statistical computational techniques addressing limitations pioneer studies have led to novel findings triggered re-evaluation current practices. As part World Health Organization's Better Outcomes Labour Difficulty (BOLD) project, which aimed develop new monitoring-to-action...
: To estimate the effects of reproductive tract infections (RTIs) on HIV acquisition among Zimbabwean and Ugandan women.: A multicenter prospective observational cohort study enrolled 4439 HIV-uninfected women aged 18 to 35 attending family planning clinics in Zimbabwe Uganda. Participants were interviewed, tested for RTIs every 3 months 15 24 months. They received risk reduction counseling, male condoms, treatment curable RTIs.: Despite counseling regular screening RTIs, incidence did not...
Objectives: High levels of HIV-1 viremia exist in peripheral blood during acute and early infection; however, data on viral loads female genital secretions this period are sparse. Design: Prospective cohort 188 African women with primary infection. Methods: HIV-uninfected infected were followed quarterly; we tested serial plasma specimens by HIV PCR to estimate infection dates. We used the Loess procedure magnitude timing setpoints cervical generalized estimating equations (GEE) identify...
Highlights•Subtype C is the dominant HIV-1 strain in epidemic infecting >15 million.•Women infected with subtype viruses have slower disease than those A or D viruses.•Long term non-progression more common as compared to women.•In CD4+ T cells are less fit viruses.•Subtype virus envelopes function reduced kinetic rate both cell-free and cell-cell assays.HIV-1 has expanded human population dominate global just 10–20years. Despite 15 million people C, our 15year study on natural history of HIV...
To compare two cervical cancer screening methods: community-based self-collection of high-risk human papillomavirus (HR-HPV) testing and visual inspection with acetic acid (VIA).Pilot randomised controlled trial 500 women aged 30-65 in the community Kisenyi, Uganda. Women to self-collection-based HR-HPV provided a cervico-vaginal swab for HR-HPV, results were by phone after laboratory testing. who tested HPV positive referred VIA at local health unit. underwent unit, where cryotherapy time...
To define embarrassment and develop an understanding of the role in relation to cervical cancer screening self-collected human papillomavirus (HPV) DNA testing Uganda.
Face-mask ventilation is the most common resuscitation method for birth asphyxia. Ventilation with a cuffless laryngeal mask airway (LMA) has potential advantages over face-mask during neonatal in low-income countries, but whether use of an LMA reduces mortality and morbidity among neonates asphyxia unknown.In this phase 3, open-label, superiority trial Uganda, we randomly assigned who required positive-pressure to be treated by midwife or ventilation. All had estimated gestational age at...
BackgroundLate initiation of antiretrovirals in pregnancy is associated with increased risk perinatal transmission and higher infant mortality. We report the final 72-week postpartum results for efficacy safety dolutegravir-based compared efavirenz-based regimens mothers infants.MethodsDolPHIN-2 was a randomised, open-label trial. Pregnant women South Africa Uganda aged at least 18 years, untreated but confirmed HIV infection an estimated gestation 28 weeks, initiating antiretroviral therapy...
Abstract Background Menstrual problems affect as high 90% of adolescent females and are the main reason for gynecology visits. Dysmenorrhea was most frequent menstrual disorder which adolescents their parents were referred to a physician. Many undergraduate students who undergo several hormonal changes that patterns. This study aimed determine prevalence disorders effect on quality life (QOL) female at Makerere University college health sciences. Methods A cross sectional design using...
Abstract Background. For every maternal death, there are probably 100 or more morbidities, but the quality of health care for these women who survive has rarely been an issue. The purpose this study is to explore audit severe obstetric morbidity and concept near miss in four referral hospitals Uganda. Methods. This was exploratory systematic enquiry into a subset with designated as cases by organ failure dysfunction. Patient factors environmental were also explored. Data abstracted from...
Uganda has a high maternal mortality ratio with unsafe abortions being one of the major causes. Young people are particularly vulnerable to induced abortion its sequelae. Emergency contraception (EC) may reduce if easily accessible and acceptable.To determine knowledge about, ever use attitudes towards EC among resident non-resident female first year university students in Kampala.This Cross sectional study was carried out at Makerere University from January March 2005.Out 5971 females...
Objective Mortality rates from birth asphyxia in low-income countries remain high. Face mask ventilation (FMV) performed by midwives is the usual method of resuscitating neonates such settings but may not always be effective. The i-gel a cuffless laryngeal airway (LMA) that could enhance neonatal resuscitation performance. We aimed to compare LMA and face (FM) during low-resource setting. Setting Mulago National Referral Hospital, Kampala, Uganda. Design This prospective randomised clinical...
Introduction Two million women worldwide are living with genital fistula an annual incidence of 50,000–100,000 women. Risk factors for obstetric context bound. Studies from other countries show variation in the risk fistula. This study was conducted to identify western Ugandan context. Methods A case control comparing background (cases) and without (controls) Uganda. Data collected using face-to-face interviews. Univariate, bivariate multivariate analysis Stata 12. Results Altogether, 420...