A5088904489- Cervical Cancer and HPV Research
- Neonatal and Maternal Infections
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- Global Cancer Incidence and Screening
- Streptococcal Infections and Treatments
- Genital Health and Disease
- Global Maternal and Child Health
- Maternal and Neonatal Healthcare
- Infant Development and Preterm Care
- Viral-associated cancers and disorders
- COVID-19 epidemiological studies
- Reproductive tract infections research
- Preterm Birth and Chorioamnionitis
- DNA Repair Mechanisms
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Early Childhood Education and Development
- Child Nutrition and Water Access
- Molecular Biology Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Global Health and Epidemiology
- Phytoestrogen effects and research
London School of Hygiene & Tropical Medicine
2019-2025
University of Pittsburgh
2012-2020
Metropolitan University
2019
Program for Appropriate Technology in Health
2011-2015
Johns Hopkins University
2009-2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Pittsburg State University
2013
Seattle University
2011
Dana-Farber Cancer Institute
2003-2005
Harvard University
2001-2005
Objective To assess human papillomavirus (HPV) vaccination coverage after demonstration projects conducted in India, Peru, Uganda and Viet Nam by PATH national governments to explore the reasons for vaccine acceptance or refusal.Methods Vaccines were delivered through schools health centres combination with other interventions, either monthly campaigns at fixed time points.Using a two-stage cluster sample design, authors selected households project areas interviewed over 7000 parents...
Vaginal self-sampling with HPV-DNA tests is a promising primary screening method for cervical cancer. However, women’s experiences, concerns and the acceptability of such in low-resource settings remain unknown. In India, Nicaragua, Uganda, mixed-method design was used to collect data from surveys (N = 3,863), qualitative interviews 72; 20 providers 52 women) focus groups 30 on providers’ experiences self-sampling, opinions sampling at home, their future needs. Among surveyed women, 90%...
This study evaluates the feasibility and performance of careHPV, a novel human papillomavirus (HPV) DNA test, when used for screening women cervical cancer in low-resource settings.Clinician-collected (cervical) self-collected (vaginal) careHPV specimens, visual inspection with acetic acid (VIA), Papanicolaou test were evaluated among 16,951 eligible India, Nicaragua, Uganda. Women positive results received colposcopy histologic follow-up as indicated. The positivity each method was...
Background While many studies have compared the efficacy of Pap cytology, visual inspection with acetic acid (VIA) and human papillomavirus (HPV) DNA assays for detection cervical intraepithelial neoplasia cancer, few evaluated program effectiveness. Methods Findings A population-based sample 5603 women from Medchal Mandal in Andhra Pradesh, India were invited to participate a study comparing VIA, HPV screening CIN3+. Participation primary all subsequent follow-up visits was rigorously...
BackgroundGroup B Streptococcus (GBS) disease is a leading cause of neonatal death, but its long-term effects have not been studied after early childhood. The aim this study was to assess mortality, neurodevelopmental impairments (NDIs), and economic outcomes infant invasive GBS (iGBS) up adolescence in Denmark the Netherlands.MethodsFor cohort study, children with iGBS were identified Netherlands using national medical administrative databases culture results that confirmed their diagnoses....
Abstract New, lower-cost tests that target high-risk human papillomavirus (HR-HPV) have been developed for cervical cancer screening in lower-resource settings but large, population-based studies are lacking. Women ages 25 to 65 years and living rural China (n = 7,543) self-collected a cervicovaginal specimen, had 2 specimens collected by clinician, underwent visual inspection after acetic acid (VIA). The self- one clinician-collected HR-HPV DNA testing careHPV (QIAGEN) Hybrid Capture (HC2;...
Using human papillomavirus (HPV) testing for cervical cancer screening in lower‐resource settings (LRS) will result a significant number of screen‐positive women. This analysis compares different triage strategies detecting precancer and among HPV‐positive women LRS. was population‐based study aged 25–65 years living China ( n = 7,541). Each woman provided self‐collected two clinician‐collected specimens. The one specimen were tested by HPV DNA tests— care HPV™ Hybrid Capture 2; the other...
New vaccine introductions have put strains on supply chains around the world. While increasing storage and transportation may be most straightforward options, it is also important to consider what financial operational benefits can incurred. In 2012, suboptimal coverage impending prompted Republic of Benin's Ministry Health (MOH) explore ways improve their chain.Working alongside Beninese MOH, we utilized our computational model, HERMES, impact cost availability three possible options: (1)...
Group B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth preterm birth. GBS vaccines are under development, but their potential health impact cost-effectiveness have not been assessed globally.
Abstract Cervical cancer is preventable but continues to cause the deaths of more than 270,000 women worldwide each year, most them in developing countries where programs detect and treat precancerous lesions are not affordable or available. Studies have demonstrated that screening by visual inspection cervix using acetic acid (VIA) a simple, affordable, sensitive test can identify changes so treatment such as cryotherapy be provided. Government partners implemented VIA at demonstration...
Objective: The aim of this research was to determine correlates prevalent cervicovaginal human papillomavirus (HPV) infection in perimenopausal women. Methods: A total 178 women, ages 40–60, were recruited from four clinics the metropolitan area Baltimore, Maryland. self-collected specimen and questionnaire completed following enrollment consent. HPV detected by L1 consensus polymerase chain reaction (PCR) genotyped using a prototype line blot assay. Adjusted prevalence ratios (aPR) 95%...
Abstract Objectives: Our aim was to determine if (1) Hybrid Capture 2 and a PCR-based method were comparable for detection of high-risk human papillomavirus (HPV) clinician-collected self-collected samples equally efficient detect HPV cervical cancer precursor lesions, (3) participation rates improved with home-based versus clinic-based self collection. Methods: Samples selected from women participating in screening study according HPV, visual inspection acetic acid, or Pap smear results....
Background When addressing the urgent task of improving vaccine supply chains, especially to accommodate introduction new vaccines, there is often a heavy emphasis on stationary storage. Currently, donations chains occur largely in form storage equipment. Methods This study utilized HERMES-generated detailed, dynamic, discrete event simulation model Niger chain compare impacts availability adding cold versus transport capacity at different levels and determine whether alone would be enough...
Many of the world's vaccine supply chains do not adequately provide vaccines, prompting several questions: how are currently structured, these structures closely tailored to individual countries, and should be radically redesigned?We segmented 57 GAVI-eligible countries' based on their structure/morphology, analyzed whether segments correlated with differences in country characteristics, then utilized HERMES develop a detailed simulation model three sample explore cost impact various...
This study examined the efficacy of OncoE6™ Cervical Test, careHPV™ and visual inspection with acetic acid (VIA) in identifying women at risk for cervical cancer their capability to detect incident precancer 1-year follow-up. In a population 7,543 living rural China, provided self-collected two clinician-collected specimens underwent VIA. All screen positive any tests, ∼ 10% random sample test-negative that colposcopy baseline, an additional who did not undergo baseline (n = 3,290) were...
Understanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination.We conducted a prospective cohort study Baltimore, Maryland. Women aged 35-60 years underwent testing completed health sexual behavior questionnaires every 6 months over 2-year period. New detection/loss detection rates were calculated adjusted hazard ratios used identify risk factors for new detection.The loss analyses...