A5040519010- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Neonatal and Maternal Infections
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Parasites and Host Interactions
- Pneumonia and Respiratory Infections
- Otolaryngology and Infectious Diseases
- Respiratory viral infections research
- Child Nutrition and Water Access
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Parasite Biology and Host Interactions
- COVID-19 and healthcare impacts
- Trace Elements in Health
- Bacterial Infections and Vaccines
- Dermatological diseases and infestations
- Malaria Research and Control
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Iron Metabolism and Disorders
National Institute for Public Health and the Environment
2017-2024
Health Forecasting
2024
Amsterdam University Medical Centers
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2018
Vrije Universiteit Amsterdam
2015-2016
Leiden University Medical Center
2010-2015
Instituut voor Tropische Geneeskunde
2014
Given the emergence of SARS-CoV-2 Omicron BA.1 and BA.2 variants roll-out booster COVID-19 vaccination, evidence is needed on protection conferred by primary vaccination previous infection variant. We employed a test-negative design S-gene target failure data from community PCR testing in Netherlands 22 November 2021 to 31 March 2022 (n = 671,763). Previous infection, or both protected well against Delta infection. Protection was much lower compared Delta. similar after vaccination. Higher...
In 2022, a sevenfold increase in the number of notifiable invasive
We present early vaccine effectiveness (VE) estimates of the 2023 seasonal COVID-19 XBB.1.5 against hospitalisation and admission to an intensive care unit (ICU) in previously vaccinated adults ≥ 60 years Netherlands. compared vaccination status 2,050 hospitalisations including 92 ICU admissions with age group-, sex-, region- date-specific population coverage between 9 October 5 December 2023. VE was 70.7% (95% CI: 66.6–74.3), 73.3% 42.2–87.6).
We estimated vaccine effectiveness (VE) of SARS-CoV-2 Omicron XBB.1.5 vaccination against self-reported infection between 9 October 2023 and January 2024 in 23,895 vaccine-eligible adults who had previously received at least one booster. VE was 41% (95% CI: 23–55) 18–59-year-olds 50% 44–56) 60–85-year-olds. Sequencing data suggest lower protection the BA.2.86 (including JN.1) variant from recent prior (OR = 2.8; 95% CI:1.2–6.5) and, not statistically significant, 1.5; CI:0.8–2.6).
Chronic helminth infections induce T-cell hyporesponsiveness, which may affect immune responses to other pathogens or vaccines. This study investigates the influence of Treg activity on proliferation and cytokine BCG Plasmodium falciparum-parasitized RBC in Indonesian schoolchildren. Geohelminth-infected children's vitro either pRBC was reduced compared that uninfected children. Although frequency CD4(+)CD25(hi)FOXP3(+) T cells similar regardless infection status, suppressive differed...
Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine transmission (VET). We present estimates VET to household other close contacts in Netherlands, from February May 2021, using contact monitoring data. The secondary attack rate among was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with adjusted 71% (95% confidence interval: 63–77).
We estimated SARS-CoV-2 vaccine effectiveness against onward transmission by comparing secondary attack rates among household members for vaccinated and unvaccinated index cases, based on source contact tracing data collected when the Delta variant was dominant. Effectiveness of full vaccination case to fully contacts, respectively, 63% (95% confidence interval (CI): 46–75) 40% CI: 20–54), in addition direct protection contacts infection.
BackgroundGroup B Streptococcus (GBS) disease is a leading cause of neonatal death, but its long-term effects have not been studied after early childhood. The aim this study was to assess mortality, neurodevelopmental impairments (NDIs), and economic outcomes infant invasive GBS (iGBS) up adolescence in Denmark the Netherlands.MethodsFor cohort study, children with iGBS were identified Netherlands using national medical administrative databases culture results that confirmed their diagnoses....
Abstract An increasing proportion of the population has acquired immunity through COVID-19 vaccination and previous SARS-CoV-2 infection, i.e., hybrid immunity, possibly affecting risk new infection. We aim to estimate protective effect infections vaccinations on Omicron using data from 43,257 adult participants in a prospective community-based cohort study Netherlands, collected between 10 January 2022 1 September 2022. Our results show that, for with 2, 3 or 4 prior immunizing events...
We used data of 32,542 prospective cohort study participants who previously received primary and one or two monovalent booster COVID-19 vaccinations. Between 26 September 19 December 2022, relative effectiveness bivalent original/Omicron BA.1 vaccination against self-reported Omicron SARS-CoV-2 infection was 31% in 18-59-year-olds 14% 60-85-year-olds. Protection higher than without prior infection. Although increases protection hospitalisations, we found limited added benefit preventing
This study reports an epidemiological assessment of laboratory-confirmed group A streptococcal meningitis cases in the Netherlands using more than 40 years national bacteriological surveillance data.
ABSTRACT Using a common protocol across seven countries in the European Union/European Economic Area, we estimated XBB.1.5 monovalent vaccine effectiveness (VE) against COVID‐19 hospitalisation and death booster‐eligible ≥ 65‐year‐olds, during October–November 2023. We linked electronic records to construct retrospective cohorts used Cox models estimate adjusted hazard ratios derive VE. VE for was, respectively, 67% (95%CI: 58–74) 42–81) 65‐ 79‐year‐olds 66% 57–73) 72% 51–85) 80‐year‐olds....
A global increase in the incidence of invasive group Streptococcus (iGAS) infections was observed after lifting COVID-19 related restrictions 2022, and type M1UK dominated many countries. After seasonal declines iGAS during summer 2023, simultaneous, rapid expansion a previously rare emm 3.93 seen beginning November, increasing to 20% all cases England 60% Netherlands within 4 months. emm3.93 associated with children 6-17 years age increased risk for pneumonia or pleural empyema meningitis...
We estimated vaccine effectiveness (VE) of primary and booster vaccinations against SARS-CoV-2 infection overall in four risk groups defined by age medical condition during the Delta Omicron BA.1/BA.2 periods.VAccine Study COvid-19 is an ongoing prospective cohort study among Dutch adults. The end point was a self-reported positive test from July 12, 2021 to June 06, 2022. analyses included only participants without previous based on or serology. used Cox proportional hazard models with...
Invasive group A streptococcal (iGAS) disease cases increased in the first half of 2022 Netherlands, with a remarkably high proportion emm4 isolates. Whole-genome sequence analysis 66 isolates, 40 isolates from pre-coronavirus 2019 (COVID-19) pandemic period 2009-2019 and 26 contemporary 2022, identified novel Streptococcus pyogenes lineage (M4NL22), which accounted for 85 % iGAS 2022. Surprisingly, we detected few hypervirulent clone, has replaced nearly all other USA UK. M4NL22 displayed...
Since 2022, many countries have reported an upsurge in invasive group A streptococcal (iGAS) infections. We explored whether changes
Background Chronic schistosomiasis is associated with T cell hypo-responsiveness and immunoregulatory mechanisms, including induction of regulatory cells (Tregs). However, little known about Treg functional capacity during human Schistosoma haematobium infection. Methodology CD4+CD25hiFOXP3+ were characterized by flow cytometry their function assessed analysing total Treg-depleted PBMC responses to schistosomal adult worm antigen (AWA), soluable egg (SEA) Bacillus Calmette-Guérin (BCG) in S....
High coronavirus incidence has prompted the Netherlands to implement a second lockdown. To elucidate epidemic’s development preceding this wave, we analysed weekly test positivity in public locations by population subgroup between 1 June and 17 October 2020. Hospitality transport workers, driving instructors, hairdressers aestheticians had higher compared with reference group of individuals without close-contact occupation. Workers childcare, education healthcare showed lower positivity.