A5017457298- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Cervical Cancer and HPV Research
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Genital Health and Disease
- COVID-19 Clinical Research Studies
- Diphtheria, Corynebacterium, and Tetanus
- Viral gastroenteritis research and epidemiology
- COVID-19 and Mental Health
- Syphilis Diagnosis and Treatment
- Vector-borne infectious diseases
- Cytomegalovirus and herpesvirus research
- COVID-19 and healthcare impacts
- Hepatitis Viruses Studies and Epidemiology
- Data-Driven Disease Surveillance
- Poxvirus research and outbreaks
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
National Institute for Public Health and the Environment
2015-2024
Eindhoven Cancer Registry
2002-2023
Netherlands Organisation for Applied Scientific Research
2020
Health Forecasting
2009-2019
Dutch Expert Centre for Screening
2019
Amsterdam UMC Location University of Amsterdam
2019
Maastricht University
2017
European Centre for Disease Prevention and Control
2014
In-Q-Tel
2012
University Medical Center Utrecht
2009
In 2022, a sevenfold increase in the number of notifiable invasive
We present early vaccine effectiveness (VE) estimates of the 2023 seasonal COVID-19 XBB.1.5 against hospitalisation and admission to an intensive care unit (ICU) in previously vaccinated adults ≥ 60 years Netherlands. compared vaccination status 2,050 hospitalisations including 92 ICU admissions with age group-, sex-, region- date-specific population coverage between 9 October 5 December 2023. VE was 70.7% (95% CI: 66.6–74.3), 73.3% 42.2–87.6).
Laboratory confirmation of pertussis by culture, PCR, or detection antibody increase in paired sera is hampered low sensitivity the later stages disease. Therefore, we investigated whether, and at which level, concentrations immunoglobulin G (IgG) antibodies against toxin (PT), IgG-PT, a single serum sample are indicative active recent pertussis. measured enzyme-linked immunosorbent assay units per milliliter, was analyzed 7,756 collected population-based study The Netherlands, 3,491...
We analyzed pertussis reporting, death, hospitalization, and serodiagnostic data from 1976 to 1998 help explain the cause of 1996 outbreak in Netherlands. The unexpected was detected by an increase reporting other surveillance methods. In 1996, according serologic data, incidence among (mostly unvaccinated) children less than 1 year age similar hospital admissions. Among older vaccinated) persons, admissions relatively small. higher vaccinated unvaccinated persons all ages. This resulted...
In high income countries, vaccine-preventable diseases have been greatly reduced through routine vaccination programs. Despite this success, many parents question, and a small proportion even refuse for their children. As no qualitative studies explored the factors behind these decisions among Dutch parents, we performed study using online focus groups.In total, eight groups (n = 60) which included with at least one child, aged 0-4 years, whom they refused all or part of vaccinations within...
Background: In May 2013, a measles outbreak began in the Netherlands among Orthodox Protestants who often refuse vaccination for religious reasons. Objective: Our aim was to compare number of messages expressed on Twitter and other social media during with online news articles reported cases answer question if when reflect public opinion patterns versus disease patterns. Methods: We analyzed measles-related tweets, messages, newspaper over 7-month period (April 15 November 11, 2013) regard...
Little is known about the time span of progression from high-grade cervical intraepithelial neoplasia (CIN2/3) to invasive cancer. Estimation this duration longitudinal studies not permitted, as CIN2/3 should be treated when detected. Cross-sectional data on age-specific incidence detected and cancer cases are readily available in national registries, but these difficult interpret because neither moment lesion development nor onset observed. We developed a statistical model for estimating...
Background We aimed to detect SARS-CoV-2 serum antibodies in the general population of Netherlands and identify risk factors for seropositivity amidst first COVID-19 epidemic wave. Methods Participants (n=3207, aged 2–90 years), enrolled from a previously established nationwide serosurveillance study, provided self-collected fingerstick blood sample completed questionnaire (median inclusion date 3 April 2020). IgG targeted against spike S1-protein were quantified using validated...
Discrete Choice Experiments (DCEs) are increasingly used in studies healthcare research but there is still little empirical evidence for the predictive value of these hypothetical situations similar real life circumstances. The aim this paper to compare stated preferences a DCE and accompanying questionnaire with revealed young parents who have decide whether vaccinate their new born child against hepatitis B. A asking which scenario they would be more inclined preference was estimated by...
BackgroundDuring the COVID-19 pandemic, many countries have implemented physical distancing measures to reduce transmission of SARS-CoV-2.AimTo measure actual reduction contacts when are implemented.MethodsA cross-sectional survey was carried out in Netherlands 2016-17, which participants reported number and age their previous day. The repeated among a subsample April 2020, after strict were implemented, an extended sample June some relaxed.ResultsThe average community per day reduced from...
Abstract Background PIENTER 3 (P3), conducted in 2016/17, is the most recent of three nationwide serological surveys Netherlands. The aim to monitor effects National Immunisation Programme (NIP) by assessing population seroprevalence included vaccine preventable diseases (VPDs). response rate main sample was 15.7% ( n = 4,983), following a decreasing trend compared previous two studies (P1, 55.0%; 1995/1996 [ 8,356] and P2, 33.0%; 2006/2007 5,834]). Non-responders P3 survey were followed-up...
In 1996, a sudden increase in pertussis incidence was reported the Netherlands (2.1 per 100,000 1995, 18 1996). Although not all potential surveillance artifacts could be excluded, it is highly probable that data reflect true outbreak. However, cause of this has yet been determined. Further research directed to severity disease and possible mismatch between vaccine circulating Bordetella strains.
High titres of pertussis toxin (PT) antibody have been shown to be predictive recent infection with Bordetella pertussis. The seroprevalence standardized anti-PT was determined in six Western European countries between 1994 and 1998 related historical surveillance vaccine programme data. Standardized were calculated for a series whole-cell acellular trials. For the serological surveys, high-titre sera (> 125 units/ml) distributed throughout all age groups both high- 90%) low-coverage (<...
Routine vaccination with a single dose of conjugated meningococcal C vaccine at 14 months and catch-up campaign have reduced the incidence disease in Netherlands. In contrast to countries where routine is given infancy, failures were not reported. This suggests that one second year life might offer longer lasting protection against than 3 doses infancy.
To analyze the epidemiology of a nationwide mumps epidemic in Netherlands, we reviewed 1,557 notified cases persons who had disease onset during September 1, 2009-August 31, 2012. Seasonality peaked spring and autumn. Most case-patients were males (59%), 18-25 years age (67.9%), vaccinated twice with measles-mumps-rubella vaccine (67.7%). Nearly half (46.6%) occurred university students or student contacts. Receipt 2 doses reduced risk for orchitis, most frequently reported complication...
Since 2009, the incidence of meningococcal serogroup W disease has increased rapidly in UK because a single strain (the so-called original strain) belonging to hypervirulent sequence type-11 clonal complex (cc11), with variant outbreak 2013 emerging 2013. Subsequently, Netherlands had an increase disease. We assessed temporal and phylogenetic associations between outbreaks England, historical C both countries.For this observational cohort study, we used national surveillance data for England...
Aim This study aimed to estimate long‐term impairment attributable congenital cytomegalovirus infection ( cCMV ). Method nationwide cohort retrospectively assessed in children born 2008 the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of ‐positive n =133) and matched ‐negative comparison =274) up 6 years age were analysed. Results Moderate severe was diagnosed 24.8% (33 out 133) all (53.8% symptomatic, 17.8% asymptomatic), compared with 12.0% 274)...
Immunization schedules with pneumococcal conjugate vaccine (PCV) differ among countries regarding the number of doses, age at vaccinations, and interval between doses.To assess optimal primary vaccination schedule by comparing immunogenicity 13-valent PCV (PCV13) in 4 different immunization schedules.An open-label, parallel-group, randomized clinical trial healthy term infants a general community The Netherlands conducted June 30, 2010, January 25, 2011, 99% follow-up until 12 months.Infants...
Observational postmarketing studies are important to assess vaccine effectiveness (VE). We estimated VE from the bivalent human papillomavirus (HPV) against HPV positivity of and nonvaccine types in a high-risk population.We included all vaccine-eligible women PASSYON study, biennial cross-sectional survey Dutch sexually transmitted infection clinics. Vaginal swabs were analyzed using polymerase chain reaction-based assay (SPF10-LiPA25) able detect 12 (hrHPV)...