A5071620914- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Salmonella and Campylobacter epidemiology
- Virology and Viral Diseases
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Vibrio bacteria research studies
- HIV Research and Treatment
- Viral Infections and Vectors
- Eosinophilic Esophagitis
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
Tel Aviv University
2015-2024
New York State Psychiatric Institute
2024
New York Psychoanalytic Society and Institute
2024
Lindsay Unified School District
2023
Manhattan Institute for Policy Research
2023
New York Proton Center
2023
Communities In Schools of Orange County
2023
Oregon Medical Research Center
2023
Universidad del Rosario
2019
Inspira Medical Center Woodbury
2019
Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1); however, breadth these at single-epitope level has not been comprehensively assessed. We therefore screened peripheral blood mononuclear cells (PBMC) from 57 individuals different stages HIV-1 infection for virus-specific T-cell using matrix 504 overlapping peptides spanning all expressed proteins gamma interferon-enzyme-linked immunospot (Elispot) assay. HIV-1-specific were...
Background. Spontaneous control of human immunodeficiency virus (HIV) infection has been documented in a minority HIV-infected individuals. The mechanisms behind this outcome remain largely unknown, and better understanding them will likely influence future vaccine strategies. Methods. HIV-specific T cell antibody responses as well host genetics were examined untreated HIVinfected patients who maintain comparatively low plasma HIV RNA levels (hereafter, controllers), including those with <...
Background. Diarrhea is a leading cause of illness and death among children aged <5 years in developing countries. This paper describes the clinical epidemiological methods used to conduct Global Enteric Multicenter Study (GEMS), 3-year, prospective, age-stratified, case/control study estimate population-based burden, microbiologic etiology, adverse consequences acute moderate-to-severe diarrhea (MSD) censused population 0–59 months seeking care at health centers sub-Saharan Africa South...
Shigella case isolates from the Global Enteric Multicenter Study were serotyped to guide vaccine development. A quadrivalent that includes O antigens S. sonnei, flexneri 2a, 3a, and 6 should provide broad protection. Background. Shigella, a major diarrheal disease pathogen worldwide, is target of The (GEMS) investigated burden etiology moderate-to-severe in children aged <60 months matched controls without diarrhea during 3 years at 4 sites Africa Asia. was 1 most common pathogens across age...
Abstract Background Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were shown to be highly efficacious in preventing the randomized controlled trials; nonetheless, evidence on real-world effectiveness of this vaccine is limited. Study objective was evaluate BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19-related hospitalization mortality. Methods This historical cohort study included members a large health provider Israel that...
Abstract Background Reports of waning vaccine-induced immunity against COVID-19 have begun to surface. With that, the comparable long-term protection conferred by previous infection with SARS-CoV-2 remains unclear. Methods We conducted a retrospective observational study comparing three groups: (1)SARS-CoV-2-naïve individuals who received two-dose regimen BioNTech/Pfizer mRNA BNT162b2 vaccine, (2)previously infected not been vaccinated, and (3)previously single dose vaccinated individuals....
Abstract Background Waning of protection against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) conferred by doses the BNT162b2 vaccine begins shortly after inoculation and becomes substantial within 4 months. With that, impact prior on incident SARS-CoV-2 reinfection is unclear. Therefore, we examined long-term naturally acquired immunity (protection previous infection) compared to vaccine-induced immunity. Methods A retrospective observational study 124 500...
<h3>Importance</h3> The BNT162b2 vaccine showed high efficacy against COVID-19 in a phase III randomized clinical trial. A effectiveness evaluation real-world setting is needed. <h3>Objective</h3> To assess the short-term of first dose BNT162b2-vaccine SARS-CoV-2 infection 13 to 24 days after immunization setting. <h3>Design, Setting, and Participants</h3> This comparative study used data from 2.6 million-member state-mandated health care system Israel. Participants included all individuals...
Virus-specific CD8+ T cells are associated with declining viremia in acute human immunodeficiency virus (HIV)1 infection, but do not correlate control of chronic suggesting a progressive functional defect measured by interferon γ assays presently used. Here, we demonstrate that HIV-1–specific proliferate rapidly upon encounter cognate antigen lose this capacity ongoing viral replication. This can be induced vitro depletion CD4+ or addition interleukin 2–neutralizing antibodies, and corrected...
ABSTRACT Although there is increasing evidence that virus-specific cytotoxic-T-lymphocyte (CTL) responses play an important role in the control of human immunodeficiency virus (HIV) replication vivo, only scarce CTL data are available for ethnic populations currently most affected by epidemic. In this study, we examined CD8 + -T-cell African-American, Caucasian, Hispanic, and Caribbean which clade B dominates analyzed potential factors influencing immune recognition. Total HIV-specific were...
Background. In the United States, anal cancer in men who have sex with (MSM) is more common than cervical women. Human papillomavirus (HPV) causally linked to development of and cancer. women, HPV infection peaks early decreases after age 30. Little known about age-specific prevalence human immunodeficiency virus (HIV)-negative MSM. Methods. We studied determinants 1218 HIV-negative MSM, 18–89 years old, were recruited from 4 US cities. assessed status by polymerase chain reaction. Results....
The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) chromosomal locus iuc (encoding aerobactin) (S. Barzu, A. Fontaine, P. J. Sansonetti, Phalipon, Infect. Immun. 64:1190-1196, 1996). Dose selection studies showed that causes shigellosis in a majority volunteers when 3 x 10(8) or 2 10(6) CFU are ingested. In contrast, dose 10(4) was associated with transient fever mild diarrhea 15 volunteers....
Storage patterns in geophytes are integrated into one general scheme.Two recognized: which flowers and leaves appear simultaneously (synanthous) different seasons (hysteranthous).Within each pattern two variants can be recognized, those with annual perennial storage organs.The developmental cycle of organs, leaves, seeds characteristic type is related to ecological conditions possible selection pressure.Large organs expected found plants arid unpredictable areas.Hysteranthous more frequent climates.
Approximately 164,000 deaths yearly are due to shigellosis, primarily in developing countries. Thus, a safe and affordable Shigella vaccine is an important public health priority. The GSK Vaccines Institute for Global Health (GVGH) developed candidate sonnei (1790GAHB) using the Generalized Modules Membrane Antigens (GMMA) technology. paper reports results of 1790GAHB Phase 1 studies healthy European adults.To evaluate safety immunogenicity profiles 1790GAHB, we performed two parallel, phase...
Abstract Background BNT162b2 vaccines showed high efficacy against COVID-19 in a randomised controlled phase-III trial. A vaccine effectiveness evaluation real life settings is urgently needed, especially given the global disease surge. Hence, we assessed short-term of first dose BNT162b2-vaccine SARS-CoV-2 infection. Given Phase-III results, hypothesized that cumulative incidence infection among vaccinees will decline after 12 days following immunization compared to during preceding days....