A5072398413- Bone health and osteoporosis research
- Bone health and treatments
- Hip and Femur Fractures
- Bone and Joint Diseases
- Liver Disease Diagnosis and Treatment
- Pregnancy and Medication Impact
- Bone Metabolism and Diseases
- Infant Development and Preterm Care
- Diabetes Treatment and Management
- Glaucoma and retinal disorders
- COVID-19 Impact on Reproduction
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Retinal Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Retinal Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
- Child and Adolescent Health
- Lipoproteins and Cardiovascular Health
- Neonatal Respiratory Health Research
- Radiomics and Machine Learning in Medical Imaging
- Gastroesophageal reflux and treatments
- Pharmacological Effects and Toxicity Studies
- Iron Metabolism and Disorders
IMI TAMI Institute for Research and Development
2023-2025
Maccabi Institute for Health Services Research
2017-2025
Tel Aviv University
2012-2025
General Department of Preventive Medicine
2023
Maccabi Health Care Services
2012-2022
Sheba Medical Center
2016
University of Brighton
2012
Data on BNT162b2 messenger RNA (mRNA) vaccine (Pfizer-BioNTech) effectiveness and safety in pregnancy are currently lacking because pregnant women were excluded from the phase 3 trial.To assess association between receipt of mRNA risk SARS-CoV-2 infection among women.This was a retrospective cohort study within registry large state-mandated health care organization Israel. Pregnant vaccinated with first dose December 19, 2020, through February 28, 2021, 1:1 matched to unvaccinated by age,...
Abstract Background Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were shown to be highly efficacious in preventing the randomized controlled trials; nonetheless, evidence on real-world effectiveness of this vaccine is limited. Study objective was evaluate BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19-related hospitalization mortality. Methods This historical cohort study included members a large health provider Israel that...
Pregnant women were excluded from the BNT162b2 messenger RNA (mRNA) COVID-19 vaccine (Pfizer-BioNTech) preauthorization trial. Therefore, observational data on safety for prenatally exposed newborns are critical to inform recommendations maternal immunization.To examine whether mRNA vaccination during pregnancy is associated with adverse neonatal and early infant outcomes among newborns.Population-based cohort study comprising all singleton live births in March through September 2021, within...
Abstract Objective The use of risk prediction models grows as electronic medical records become widely available. Here, we develop and validate a model to identify individuals at increased for colorectal cancer (CRC) by analyzing blood counts, age, sex, then determine the model’s value when used supplement conventional screening. Materials Methods Primary care data were collected from cohort 606 403 Israelis (of whom 3135 diagnosed with CRC) case control UK dataset 5061 CRC cases 25 613...
Data regarding women infected with SARS-CoV-2 during early trimesters are scarce. We aimed to assess preterm birth (PTB) and small-for-gestational-age (SGA) rates in a large unselected cohort by trimester at infection overall.A retrospective study including all positive RT-PCR test non-ectopic singleton pregnancy between February 21st 2020 July 2nd 2021 (N = 2753). Each woman was matched non-infected pregnant age, last menstruation date, sector, socioeconomic status.Logistic regression...
Importance Detecting and addressing potentially modifiable factors associated with healthy development is key to optimizing a child’s potential. When investigating the outcomes of child development, it important account for disparities in feeding practices avoid confounding bias. Objectives To estimate independent association between breastfeeding attainment developmental milestones or neurodevelopmental conditions. Design, Setting, Participants This retrospective cohort study used data from...
To examine whether isotretinoin therapy could result in deleterious ocular effects, as previously described case report studies.Retrospective cohort study.The study was conducted using the electronic medical databases of a large health maintenance organization Israel.The population consisted 14 682 adolescents and young adults who were new users for acne 2 age- sex-matched comparison groups (isotretinoin-naive patients with acne-free patients).Ocular adverse effects (AEs) or purchases...
To investigate the association between persistent use of statins and risk age-related macular degeneration (AMD).A population-based retrospective cohort among adults who began statin therapy 1998 2006 in a large health organization Israel. The organization's central computerized databases were used to collect data on incident AMD cases diagnosed by ophthalmologists.A total 108,973 individuals aged 55 or older identified. During study follow-up period 409,113 person-years, there 2,732 (6.68...
Background Osteoporosis is a systemic skeletal disorder characterized by impaired bone quality and microstructural deterioration leading to an increased propensity fractures. This major health problem for older adults, which comprise increasingly greater proportion of the general population. Due large number patients insufficient availability specialists in Israel worldwide, osteoporosis treated part primary care physicians. We assessed knowledge physicians on diagnosis treatment...
The predictive value of the World Health Organization's Fracture Risk Assessment Tool (FRAX) was evaluated using real-world community data. A population-based cohort 141,320 women aged 50-90 years (median age, 58 years; interquartile range, 54-67) in 2004 extracted from central database a large Israeli health-care services provider and insurer. Retrospective FRAX scores were calculated computerized health records compared with actual incidence major osteoporotic fractures (MOFs) during...
Preeclampsia, a severe unpredictable complication of pregnancy, occurs in 6% pregnancies, usually the second or third trimester. The specific etiology preeclampsia remains unclear, although pathophysiological hallmark this condition appears to be an inadequate blood supply placenta. As result impaired placental flow, intrauterine growth restriction (IUGR) and consequential fetal oxidative stress may occur. Consistent with view, pregnancies complicated by IUGR are characterized up-regulation...
To validate the use of drug dispensing data as a measure exposure and to quantify association between persistence with statin therapy low-density lipoprotein cholesterol (LDL) levels using real-life community data.Retrospective, population-based cohort study.Maccabi Healthcare Services (MHS) database, which contains linked prescription information, hospitalization records, laboratory test results 2 million members second largest health organization in Israel.A total 87,219 primary prevention...
Bisphosphonate (BP) treatment to prevent bone loss in breast cancer patients is already well established. However, data on the association between oral BP exposure before diagnosis and disease outcomes with early are still scarce. Limited information available alendronate, most common agent for of post-menopausal osteoporosis, regarding metastases. To examine bisphosphonate risk metastases osteoporotic women diagnosed cancer. This historical cohort study was conducted at oncology division...