A5068703662- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Viral Infections and Outbreaks Research
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Global Maternal and Child Health
- Malaria Research and Control
- Pregnancy and Medication Impact
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- Syphilis Diagnosis and Treatment
- Disaster Response and Management
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- Drug Transport and Resistance Mechanisms
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
- HIV/AIDS Impact and Responses
- Pharmacogenetics and Drug Metabolism
- Vaccine Coverage and Hesitancy
Infectious Diseases Institute
2016-2025
Makerere University
2016-2025
University of Edinburgh
2023
Ministry of Health
2017-2020
Monterey Bay Aquarium Foundation
2020
World Health Organization
2020
Centers for Disease Control and Prevention
2020
United States Army Medical Research Institute of Infectious Diseases
2020
Mulago Hospital
2017-2020
University of Minnesota
2017-2019
Abstract Background Since the declaration of 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission enable timely detection, investigation, response event a confirmed country. We describe Uganda’s experience preparedness. Results On 4 August Uganda Ministry Health (MoH) activated Public Emergency Operations Centre (PHEOC) National Task Force (NTF) for...
Background The global transition to use of dolutegravir (DTG) in WHO-preferred regimens for HIV treatment is limited by lack knowledge on pregnancy. Here we assessed the relationship between drug concentrations (pharmacokinetics, PK), including breastmilk, and impact viral suppression when initiated third trimester (T3). Methods findings In DolPHIN-1, HIV-infected treatment-naïve pregnant women (28–36 weeks gestation, age 26 (19–42), weight 67kg (45–119), all Black African) Uganda South...
Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. already been tested Ebola virus disease and found to have activity against SARS MERS coronaviruses. The remdesivir core contains GS-441524, which interferes with RNA-dependent RNA polymerases alone. In non-human primates, following IV administration, is rapidly distributed into PBMCs converted within 2 h active nucleoside triphosphate form, while GS-441524...
ObjectivesCo-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between and efavirenz or nevirapine.
Background. Levonorgestrel subdermal implants are preferred contraceptives with an expected failure rate of <1% over 5 years. We assessed the effect efavirenz- or nevirapine-based antiretroviral therapy (ART) coadministration on levonorgestrel pharmacokinetics.
Yukari Manabe and colleagues evaluate the cost-effectiveness budget impact of antenatal syphilis screening for 43 countries in sub-Saharan Africa estimate universal on averted stillbirths, neonatal deaths, congenital syphilis, DALYs. Please see later article Editors' Summary
BackgroundLate initiation of antiretrovirals in pregnancy is associated with increased risk perinatal transmission and higher infant mortality. We report the final 72-week postpartum results for efficacy safety dolutegravir-based compared efavirenz-based regimens mothers infants.MethodsDolPHIN-2 was a randomised, open-label trial. Pregnant women South Africa Uganda aged at least 18 years, untreated but confirmed HIV infection an estimated gestation 28 weeks, initiating antiretroviral therapy...
Sickle cell disease (SCD) constitutes a major public health problem in sub-Saharan Africa (SSA). Newborn screening and early subsequent clinical intervention can reduce mortality increase life expectancy, but have not been widely implemented SSA. This analysis assesses the cost-effectiveness of newborn prophylactic (NSPI) package for SCD 47 SSA countries.A lifetime Markov model with annual cycles was built infants either being screened using isoelectric focusing (IEF) or screened. Confirmed...
In Brief Background Untreated syphilis in pregnancy is associated with adverse clinical outcomes to the infant. The study aimed estimate public health burden resulting from due infection among pregnant women not screened for 43 countries sub-Saharan Africa. Methods Estimated country-specific incidence of was generated annual number live births, proportion at least 1 antenatal care (ANC) visit, prevalence rate, and during ANC. Adverse outcome data (stillbirth, neonatal death, low birth...
Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these quantify their effect, the dose adjustments necessary for optimal drug concentrations.
Abstract Background Throughout the last decade, tuberculosis (TB) treatment success has not surpassed 90%, global target. The impact of mobile health interventions (MHIs) on TB outcomes is unknown, especially in low- and middle-income countries (LMICs). MHIs, including interactive voice response technology (IVRT), may enhance adherence retention care patients with improve outcomes. This study seeks to determine IVRT-based MHI (treatment completion cure rates) receiving at five public...
Antimicrobial resistance (AMR) is an emerging public health crisis in Uganda. The World Health Organization (WHO) Global Action Plan recommends that countries should develop and implement National Plans for AMR. We describe the establishment of national AMR program Uganda present early microbial sensitivity results from program.The aim this study to a surveillance was developed perform systematic continuous collection, analysis, interpretation data.A qualitative description process progress...
Traditional herbal medicines are commonly used in sub-Saharan Africa and some herbs known to be hepatotoxic. However little is about the effect of on liver disease Africa.
BackgroundTreatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisinin-based combination has potential for drug interactions. We investigated the pharmacokinetics artemether, dihydroartemisinin lumefantrine after administration a single dose 80/480 mg artemether/lumefantrine to HIV-infected adults, taken without lopinavir/ritonavir.
HIV/AIDS clinics in Uganda and other low-income countries face increasing numbers of patients workforce shortages. We performed a cost-effectiveness analysis comparing Pharmacy-only Refill Program (PRP), form task-shifting, to the Standard Care (SOC) at large clinic Uganda, Infectious Diseases Institute (IDI). The PRP was started reduce shortages optimize patient care by substituting pharmacy visits for SOC involving monthly physician accessing antiretroviral medicines.We used retrospective...
To model the cost-effectiveness in Uganda of combination antiretroviral therapy (ART) to prevent mother-to-child transmission human immunodeficiency virus (HIV).The ART was evaluated on assumption that reduces risk an HIV-positive pregnant woman transmitting HIV her baby from 40% (when is left untreated) 25.8%, 17.4% and 3.8%, respectively, when given: (i) single-dose nevirapine (at estimated total drug cost 0.06 United States dollars [US$]); (ii) dual with zidovudine lamivudine for 7 weeks...
Drug-drug interactions between antimalarial and antiretroviral drugs may influence treatment outcomes. The aim of this study was to investigate the potential drug-drug drugs, lumefantrine, artemether their respective metabolites desbutyl-lumefantrine dihydroartemisinin, HIV efavirenz, nevirapine lopinavir/ritonavir.Data from two clinical studies, investigating lopinavir/ritonavir on pharmacokinetics metabolites, in infected patients were pooled analyzed using a non-linear mixed effects...
The relationship between concentrations of antituberculosis drugs, sputum culture conversion, and treatment outcome remains unclear. We sought to determine the association drug conversion among patients coinfected with tuberculosis human immunodeficiency virus (HIV) receiving first-line drugs. enrolled HIV-infected Ugandans pulmonary tuberculosis. Estimation was performed 1, 2, 4 hours after intake at 8, 24 weeks treatment. Serial cultures were each visit. Time-to-event analysis used factors...
Background Snakebite poisoning is a significant medical problem in agricultural societies Sub Saharan Africa. Antivenom (AV) the standard treatment, and we assessed cost-effectiveness of making it available 16 countries West Methods We determined AV based on decision-tree model from public payer perspective. Specific AVs included were Antivipmyn, FAV Afrique, EchiTab-G EchiTab-Plus. derived inputs literature which included: type snakes causing bites (carpet viper (Echis species)/non-carpet...