A5101529868- Dementia and Cognitive Impairment Research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Information and Cyber Security
- Health, Environment, Cognitive Aging
- Fish Ecology and Management Studies
- Substance Abuse Treatment and Outcomes
- Health and Wellbeing Research
- HIV-related health complications and treatments
- Coastal wetland ecosystem dynamics
- Information Technology Governance and Strategy
- Antibiotics Pharmacokinetics and Efficacy
- Cybercrime and Law Enforcement Studies
- Antibiotic Use and Resistance
- Transportation and Mobility Innovations
- Suicide and Self-Harm Studies
- Poverty, Education, and Child Welfare
- Marine and coastal plant biology
- Mental Health Treatment and Access
- Traffic and Road Safety
- Migration, Health and Trauma
- Network Security and Intrusion Detection
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2015-2024
Indiana University
2024
Parkland Memorial Hospital
2023
Capella University
2005-2018
Bristol-Myers Squibb (United Kingdom)
2012
Rutgers, The State University of New Jersey
2003-2007
University of California, Los Angeles
2007
Pfizer (United States)
2006
New York University
2006
Background:The perception of cognitive decline by individuals and those who know them well ("informants") has been inconsistently associated with objective performance, but strongly depressive symptoms. Objective:We investigated associations self-report, informant-repor t, discrepancy between self- informant-report obtained from the Cognitive Change Index (CCI) test performance self-reported Methods:267 participants normal cognition, mild impairment (MCI), or dementia were included a cohort...
Purpose The objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are (i) delivery combination antiretroviral therapy (ART) in children, adolescents and adults sub-Saharan Africa, (ii) describe ART regimen effectiveness, durability tolerability, (iii) examine HIV-related comorbidities coinfections (iv) pregnancy-related outcomes women on their infants exposed HIV or utero via breast milk. Participants IeDEA is organised four regions (Central, East, Southern West...
Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages Alzheimer's disease.Multishell data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 mild impairment [MCI]). White 27 major tracts interest was assessed using diffusion tensor (DTI), neurite orientation dispersion density imaging, q-space imaging.Lower DTI fractional anisotropy higher radial diffusivity observed...
This article describes a pilot of weekly web based videoconference support group for five caregivers persons with dementia. All participants reported positive views the and medium. Improvements in caregiver anxiety, depression, physical health scores were observed. Depression remained same difficulties experienced by increasing slightly. Self-efficacy controlling upsetting thoughts responding to disruptive behavior improved but worsened slightly obtaining respite. We concluded that was...
To determine the efficacy of adding abacavir (Ziagen, ABC) to optimal stable background antiretroviral therapy (SBG) AIDS dementia complex (ADC) patients and address trial design.Phase III randomized, double-blind placebo-controlled trial.Tertiary outpatient clinics.ADC on SBG for > or = 8 wk.Participants were randomized ABC matched placebo 12 wk.The primary outcome measure was change in summary neuropsychological Z score (NPZ). Secondary measures HIV RNA immune activation markers beta-2...
Objective: To assess whether nonelevated cerebrospinal fluid (CSF) markers could delineate inactive AIDS dementia complex (ADC) in patients receiving highly active antiretroviral therapy (HAART), using neuropsychologic performance change as an indicator of ADC stability. Methods: We used data from the abacavir (ABC) trial (n = 78) and examined patients' with Reliable Change Index according to 3 cutoff groups: (1) CSF viral load (VL) <100 copies/mL, (2) β-2 microglobulin (β2m) <2.2 mg/L, (3)...
During recent years epidemiologic surveys have played an increasingly important role in the study of chronic respiratory disease. This method has been used not only to identify factors associated with development disease, but also assess effect such disease upon health and well-being individual subject. Surveys random samples total population different parts United Kingdom described by Higgins associates (1-5). A similar approach was adopted Olsen Gilson (6) compare prevalence that on...
As the older adult population increases, it is imperative to increase adults' opportunities for social involvement, thus maintaining their important roles and contributions society. While there are known health-related benefits of volunteerism among adults, a dearth information exists on perceived low-income ethnic minority adults.To understand psychosocial volunteering in Senior Companion Program present findings focus groups conducted with urban-dwelling, women volunteers.Inductive content...
The purpose of this study was to examine empirically the extent relationships between information security governance (ISG) strategic alignment and other individual domain areas consisting risk management, value delivery, performance measurement, resource management in order ascertain whether were integrated for ISG success Ghanaian organizations. Corporate theories, including agency theory, stakeholder organizational employed explore literature. These theories mapped alignment, delivery...
The purpose of this preliminary study was to determine the status IT governance in universities a developing country, Ghana, by assessing drivers and barriers pursuing formal ITG, measuring extent which align goals with academic business objectives determining ITG maturity level. Using survey questionnaire applying frequency analysis T-test independent samples, results showed that 60.6% institutions surveyed were at non-existent initial stages while only 6% managed optimized stages. also...
Abstract Introduction Rates of substance use are high among youth involved in the legal system (YILS); however, YILS less likely to initiate and complete treatment compared their non legally-involved peers. There multiple steps connecting needed services, from screening referral within juvenile initiation completion behavioral health system. Understanding potential gaps care continuum requires data decision-making these two systems. The current study reports on development dashboards that...
Objectives Almost 13 million people are estimated to be on antiretroviral therapy in Eastern and Southern Africa, their disease course program effectiveness could significantly affected by the concurrent use of alcohol. Screening for alcohol may important assess prevalence consumption its impact patient programmatic outcomes. Methods As part this observational study, data characteristics were collected a cohort 765 adult patients enrolling HIV care East Africa. Alcohol was assessed with...
We describe the design, implementation, and impact of a data harmonization, quality checking, dynamic report generation application in an international observational HIV research network. The IeDEA Harmonist Data Toolkit is web-based written open source programming language R, employs R/Shiny RMarkdown packages, leverages REDCap collection platform for model definition user authentication. performs checks on uploaded datasets, conformance with network's common model, displays results both...
Abstract Background Hazardous alcohol use among people living with HIV is associated poor outcomes and increased morbidity mortality. Understanding the hazardous drinking experiences of needed to reduce their use. Methods We conducted 60 interviews in East Africa histories. Interviews Alcohol Use Disorder Identification Test (AUDIT) scores were 41 – months after baseline assessment identify facilitators barriers reduced over time. Results People who stopped or primarily motivated by...