A5066046498- Global Health Workforce Issues
- MicroRNA in disease regulation
- Innovations in Medical Education
- Dental Education, Practice, Research
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- Cultural Competency in Health Care
- Global Health and Surgery
- Telemedicine and Telehealth Implementation
- Palliative Care and End-of-Life Issues
- Global Maternal and Child Health
- Hematopoietic Stem Cell Transplantation
- Patient-Provider Communication in Healthcare
- Primary Care and Health Outcomes
- Education Systems and Policy
- Patient Satisfaction in Healthcare
- Global Public Health Policies and Epidemiology
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Indigenous Health, Education, and Rights
- Clinical practice guidelines implementation
- Sleep and Wakefulness Research
- Healthcare Systems and Technology
- Sleep and related disorders
- Interpreting and Communication in Healthcare
James Cook University
2016-2025
University of Auckland
2025
Indiana University – Purdue University Indianapolis
2025
Australian Institute of Tropical Health and Medicine
2016-2024
Takeda (United States)
2019-2024
Sheffield Children's Hospital
2024
University of Warwick
2024
Townsville Hospital
2021-2024
NHS Lothian
2024
Ogden–Weber Applied Technology College
2023
A three-dimensional (3D) hierarchical plasmonic nano-architecture has been designed for a sensitive surface-enhanced Raman scattering (SERS) immunosensor protein biomarker detection. The capture antibody molecules are immobilized on gold triangle nanoarray pattern. On the other hand, detection linked to nanostar@Raman reporter@silica sandwich nanoparticles. When biomarkers present, nanoparticles captured over nanoarray, forming confined 3D field, leading enhanced electromagnetic field in...
To describe the use of telemedicine in cancer care (teleoncology model care) for rural patients North Queensland.This is a descriptive study. Data on demographical and clinical factors were retrieved from teleoncology database Townsville Hospital review medical records period between May 2007 2011.The oncologists at Cancer Centre, regional centre Queensland, have been providing their services to hospitals Mt Isa districts via videoconferencing since 2007. delivery sites model.The ability...
Acute lymphoblastic leukemia (ALL) initiates and progresses in the bone marrow, as such, marrow microenvironment is a critical regulatory component development of this cancer. However, ALL studies were conducted mainly on flat plastic substrates, which do not recapitulate characteristics microenvironments. To study model vivo relevance, we have engineered 3-D microfluidic cell culture platform. Biologically relevant populations primary human stromal cells, osteoblasts leukemic cells...
Narcolepsy type 1 (NT1) is a sleep disorder caused by loss of orexinergic neurons. 2 (NT2) heterogeneous; affected individuals typically have normal orexin levels. Following evaluation in mice, the effects receptor (OX2R)-selective agonist danavorexton were evaluated single- and multiple-rising-dose studies healthy adults, with NT1 NT2. In orexin/ataxin-3 narcolepsy reduced sleep/wakefulness fragmentation cataplexy-like episodes during active phase. humans, administered intravenously was...
Deficits in N-methyl-d-aspartate receptor (NMDAR) signaling are implicated the pathogenesis of schizophrenia. Luvadaxistat (TAK-831/NBI-1065844) is an investigational d-amino acid oxidase (DAAO) inhibitor that increases d-serine levels at NMDAR coagonist sites. INTERACT a phase 2 randomized, placebo-controlled study evaluated efficacy and safety three doses luvadaxistat, covering range DAAO occupancy levels, patients with schizophrenia persistent negative symptoms. The included 14-day,...
The orexin 2 receptor-selective agonist danavorexton (TAK-925) has been shown to produce wake-promoting effects in wild-type mice, narcolepsy-model and individuals with narcolepsy type 1 2. Here, we report of non-human primates healthy men during their sleep phase. Electroencephalogram analyses revealed that subcutaneous administration significantly increased wakefulness common marmosets (p < 0.05 at 0.1 mg kg-1 , p 0.001 10 ) cynomolgus monkeys ≤ 3 ). In a phase 1b crossover, randomized,...
Abstract The study of Alzheimer's disease (AD) has led to an increased understanding the multiple pathologies and pathways disease. As such, it been proposed that AD its various stages might be most effectively treated with a combination approach rather than single therapy; however, approaches present many challenges include limitations non‐clinical models, complexity clinical trial design, unclear regulatory requirements. Association Research Roundtable meeting on May 7–8, 2018, discussed...
Low-value diagnostic tests harm patients and healthcare systems. Elucidation of determinants low-value is essential for their de-implementation. The aim this study was to understand the drivers in emergency medicine (EM) practice. A qualitative descriptive conducted at an Australian academic ED. Purposive sampling used recruit participants. Semistructured interviews were collect data between February 2023 May 2023. Interviews audio-recorded, transcribed verbatim uploaded NVivo. Data...
Abstract The impact of the COVID‐19 pandemic and associated lockdown measures on child family functioning requires ongoing investigation to understand its far‐reaching effects. This study investigated experiences 10‐year‐old children ( n = 2421) from Growing Up in New Zealand longitudinal cohort during some strictest pandemic‐related 2020, with aim examining effects these several aspects children's lives wellbeing. Children reported their relation household ‘bubbles’, school, family, social...
Objectives To explore Aboriginal and Torres Strait Islander Australians’ perceptions of telehealth general practice consultations elements required for a culturally safe consultation. Design Qualitative study. Setting Primary care in three centres regional remote Australia. Participants Seventeen or individuals participated semistructured interviews exploring the experiences settings. were eligible inclusion if they Islander, over 18 years age had experienced at least one appointment with...
BXH-2 recombinant inbred (RI) mice produce high titers of B-ecotropic murine leukemia virus beginning early in life and have a incidence non-T-cell leukemias that occur before 1 year age. The develop are some cases associated with hind limb paralysis. In addition, dualtropic mink cell focus-forming has been isolated from leukemic cells mice. Immunological cytochemical characterization the showed they myeloid lineage. To assess oncogenicity viruses, newborn several BXH RI strains were...
We explored the experiences of patients using Townsville Tele-oncology clinic, where most are no longer seen face-to-face. All medical oncology who received services via telehealth at Cancer Centre in 2012 were invited to participate an interview. None refused. Thirty two interviewed by telephone and three videoconference their local health service facility. Data analysis identified five major themes (quality consultation; communication relationships; familiarity with technology initial...
To compare the dose intensity and toxicity profiles for patients undergoing chemotherapy at Townsville Cancer Centre (TCC), a tertiary cancer centre in northern Queensland, with those treated Mount Isa, supervised by same medical oncologists via teleoncology.A quasi-experimental design comparing two patient groups.TCC Isa Hospital, which both operate under auspices of Teleoncology Network (TTN).Eligible who received TCC or Mt Hospital between 1 May 2007 30 April 2012.Teleoncology model...
Abstract Acute lymphoblastic leukemia (ALL) has many features in common with normal B-cell progenitors, including their ability to respond diverse signals from the bone marrow microenvironment (BMM) resulting regulation of cell-cycle progression and survival. Bone marrow–derived cues influence elements both steady state hematopoiesis hematopoietic tumor cell phenotypes through modulation gene expression. miRNAs are one regulatory class small noncoding RNAs that have been shown be...