A5113439489- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Counseling Practices and Supervision
- Alzheimer's disease research and treatments
- Counseling, Therapy, and Family Dynamics
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Endodontics and Root Canal Treatments
- Neural dynamics and brain function
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Psychotherapy Techniques and Applications
- Retinal Imaging and Analysis
- Dental Education, Practice, Research
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Attachment and Relationship Dynamics
- Traumatic Brain Injury Research
- Educational and Psychological Assessments
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Family and Disability Support Research
Arizona State University
2009-2025
Indiana University – Purdue University Indianapolis
2013-2022
Indiana University School of Medicine
2013-2022
Indiana University
2010-2020
Alzheimer’s Disease Neuroimaging Initiative
2009-2019
University School
2011-2017
Indiana University Health
2010-2016
Medical College of Wisconsin
2015
Universidade do Porto
2015
Kent State University
1992-2013
<h3>Importance</h3> The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk dementia. To our knowledge, this the first study investigate association between AC neuroimaging biomarkers brain metabolism atrophy as a proxy for understanding underlying biology clinical effects medications. <h3>Objective</h3> assess cognition, glucose metabolism, in cognitively normal older adults from Alzheimer's Disease Neuroimaging Initiative (ADNI) Indiana Memory...
To prospectively examine alterations in working memory (WM) -associated brain activation related to breast cancer and treatment by using functional magnetic resonance imaging.Patients treated with chemotherapy (CTx+; n = 16) or without (CTx-; 12) healthy controls (n 15) were scanned during an n-back task at baseline (after surgery but before radiation, chemotherapy, and/or antiestrogen treatment), 1 month after completion of (M1), year later (Y1), yoked intervals for CTx- controls. SPM5 was...
The present investigation examined differential patterns in executive functions of children with attention-deficit hyperactivity disorder (ADHD; no diagnosed comorbid disorders) according to subtype and gender, identified instrumentation sensitive function aged 6 12 years ADHD. Data were obtained from 94 ADHD (predominantly inattentive, n = 32, combined, 62), 28 controls. Participants ADHD, who unmedicated at the time testing, administered five tests (the Wisconsin Card Sorting Test, Stroop...
Default mode network (DMN) disruption has been reported in Alzheimer's disease (AD), yet the specific pattern of altered connectivity over course prodromal AD remains to be characterized. The aim this study was assess DMN
Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify genes influencing disease pathogenesis, we performed genome-wide association study of longitudinal change brain burden measured by (18)F-florbetapir PET. A novel with higher rates accumulation independent from APOE (apolipoprotein E) ε4 status was identified IL1RAP (interleukin-1 receptor accessory protein; rs12053868-G; P = 1.38 × 10(-9)) and validated deep sequencing. rs12053868-G carriers were...
Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with remains unknown.
Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages Alzheimer's disease.Multishell data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 mild impairment [MCI]). White 27 major tracts interest was assessed using diffusion tensor (DTI), neurite orientation dispersion density imaging, q-space imaging.Lower DTI fractional anisotropy higher radial diffusivity observed...
The Knowledge about Attention Deficit Disorder Questionnaire (KADD-Q) was administered to 256 teachers and 92 parents. Statistical analysis revealed the KADD-Q be an internally consistent measure of teachers’ parents’ knowledge ADHD. Findings demonstrated that levels causes ADHD significantly higher than their characteristics ADHD, which in turn treatment. When total scores parents were compared, latter scored higher. Although there no significant differences Characteristics on Causes...
Sports-related concussion (SRC) is an important public health issue. Although standardized assessment tools are useful in the clinical management of acute concussion, underlying pathophysiology SRC and time course physiological recovery after injury remain unclear. In this study, we used diffusion tensor imaging (DTI) to detect white matter alterations football players within 48 h SRC. As part NCAA-DoD CARE Consortium study SRC, 30 American diagnosed with 28 matched controls received...
AbstractWe evaluated cerebral blood flow (CBF) in chronic pediatric mild traumatic brain injury (mTBI) using arterial spin labeling (ASL) magnetic resonance imaging perfusion. mTBI patients showed lower CBF than controls bilateral frontotemporal regions, with no between-group cognitive differences. Findings suggest ASL may be useful to assess functional abnormalities mTBI. Additional informationFundingThis work was supported by a grant from the Indiana State Department of Health Spinal Cord...
Background: Peripheral (plasma) and central (cerebrospinal fluid, CSF) measures of tau are higher in Alzheimer's disease (AD) relative to prodromal stages controls. While elevated CSF concentrations have been shown be associated with lower grey matter density (GMD) AD-specific regions , this correlation has yet examined for plasma a large study. Objective: Determine the neuroanatomical correlates using voxel-based analysis. Methods: Cross-sectional data 508 ADNI participants were collected...
Alzheimer's disease is considered a disconnection syndrome, motivating the use of brain network measures to detect changes in whole-brain resting state functional connectivity (FC). We investigated FC within and among networks (RSN) across four different stages continuum. were examined two independent cohorts individuals (84 58 individuals, respectively) each comprising control, subjective cognitive decline, mild impairment dementia groups. For participant, was computed as matrix Pearson...