Background:The perception of cognitive decline by individuals and those who know them well ("informants") has been inconsistently associated with objective performance, but strongly depressive symptoms. Objective:We investigated associations self-report, informant-repor t, discrepancy between self- informant-report obtained from the Cognitive Change Index (CCI) test performance self-reported Methods:267 participants normal cognition, mild impairment (MCI), or dementia were included a cohort...

Objective: This study investigated the characteristics of home-based activities in individuals with mild cognitive impairment (MCI) and dementia, as well factors related those activities. Materials Methods: A cross-sectional, questionnaire-based was conducted on patients MCI dementia at Siriraj Hospital. Data patient caregiver characteristics, home activities, proficiency using information technology (IT) devices telecommunications applications were collected. Home categorized into...

Objectives: This study examined the differences in brain volume and cortical thickness among individuals with normal cognition (NC) those NCDs, including mild cognitive impairment (MCI) dementia. The aim was to identify parameters supporting clinical decision-making for NCDs. Method: A total of 116 participants were categorized into dementia, MCI, NC groups, their scans using structural magnetic resonance imaging (MRI) processed automatedly analyzed FreeSurfer obtain absolute volume,...

Abstract Objectives Obstructive sleep apnea (OSA) is linked to cognitive impairment. We aimed investigate subjective complaints (SCCs) and objective scores their relation polysomnography (PSG) parameters in patients suspected of having OSA. Methods A prospective cohort cross‐sectional study was conducted at Siriraj Hospital. Patients OSA who were scheduled for PSG recruited. Cognition assessed using the Montreal Cognitive Assessment (MoCA) Color Trails Test (CTT). The Memory Index Score...

This study aimed to identify the prevalence, clinical and radiographic characteristics, risk factors for cognitive dysfunction in patients with Neuromyelitis optica spectrum disorder (NMOSD). Eighty-three participants who were diagnosed NMOSD recruited. Cognitive function was assessed using Montreal Assessment (MoCA) Frontal Battery (FAB). The mean age of 47.78 ± 13.14 years, an average 12.05 4.62 years formal education. majority (54%) exhibited impairment, defined by a MoCA score < 25...

Abstract Background There is a lack of epidemiological knowledge about whether individuals with dementia receive the same quality diagnostics and treatment. Method We explored ICD10 National Health Security Office (NHSO) in‐patient record in Thailand. analyzed prevalence, etiologies, regional distribution, outcome Thailand during 2015‐2019. reviewed cross‐sectional cohort study based on data from NHSO. Result Studied in‐patients diagnosed between 2015 2019 (n = 29,895; 40,981 visits)...

Alzheimer’s disease is a type of neurodegenerative disorder that characterized by the progressive degeneration brain cells, leading to cognitive decline and memory loss. It most common cause dementia affects millions people worldwide. While there currently no cure for disease, early detection treatment can help slow progression symptoms improve quality life. This research presents diagnostic tool classifying mild impairment diseases using feature-based machine learning applied optical...

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, fatal, neurodegenerative classified as prion diseases. There are many subtypes of this disease, but information about clinical presentation and investigation findings in Thailand scarce.

Objective: We aimed to validate Pyramids and Palm Trees test (PPT) in dementia cohort explore reliability measurement of this test. Materials Methods: The study was designed as a cross-sectional study. A total 30 subjects were recruited from the Memory Clinic at Siriraj Hospital, Thailand: 15 non-dementia adults patients (mild moderate stage). In content validation, picture version PPT given experts evaluate According consensus, some pictures with cultural issues adapted be more culturally...

Abstract Background We explored the relationship of neuropsychiatric symptoms (assesses by NPI) and Alzheimer disease pathophysiology from blood AB42/40, GFAB, NFL, pTau181. also investigated if age cognition were related to these symptoms. Method 222 subjects included 96 dementia, 66 MCI, 60 normal controls (NC). Spearman correlation was used calculation coefficient. Mann‐Whitney U test is compare biomarkers those with without subitem NPI. Result Mean ages 71.26±9.82 years old in dementia...

Abstract Background CSF biomarkers including β‐amyloid (Aβ) (1‐42), phosphorylated tau (p‐tau) 181 and total (t‐tau) are used as ante‐mortem to detect Alzheimer’s disease (AD) pathology in cognitively impaired patients. Decreased level of Aβ(1‐42), elevated p‐tau t‐tau well established AD. Base on analysis technique population, cut‐points varied distinguish between AD non‐AD neurocognitive‐disordered This study aimed evaluate the local diagnostic tools discriminate patients Thai population....

Abstract Background Hearing impairment is identified as a risk factor for dementia. This study aimed to investigate audiometric hearing level in individuals across the clinical spectrum of cognitive impairment, from normal cognition (NC) mild dementia, encompassing subjective decline (SCD) and (MCI). Method 135 participants were included this study. There 33 NC participants, 36 with SCD, 34 MCI, Demographic data was collected, along Montreal Cognitive Assessment (MoCA), Change Index capture...

Primary amebic meningoencephalitis (PAM) is a rare and fatal central nervous system infection caused by Naegleria fowleri , free-living amoeba found in the environment. To date, eight pathogenic N. genotypes have been reported worldwide. We aimed to explore of that cause primary Thailand. In 2021, 17th PAM case was reported, retrospective literature search cases Thailand from 1982 through April 2021 performed. Phylogenetic genotyping analyses two mitochondrial (12S rRNA 16S rRNA) nuclear...

Abstract Background Neuromyelitis Optica (NMO) is a demyelinating disease caused by an autoimmune process that attacks the central nervous system resulting in neurological deficit. Previous studies showed cognitive problems these patients, especially decline processing speed, episodic memory, executive function, and attention. We aimed to study prevalence factors related impairment Thai patients with NMO. Method recruited 83 participants diagnosed NMO 2015 international consensus diagnostic...

Subjective cognitive decline (SCD) is a potential early behavioral marker of mild impairment (MCI) and Alzheimer's disease (AD). We report on the correspondence between correlates self- informant-rated SCD in mixed sample healthy cognitively impaired older adults. The Cognitive Change Index 20-item scale that measures (CCI-S) (CCI-I) change memory, executive, language function. Items are rated 1-5 Likert with higher scores indicating more (range 20-100). calculated CCI difference score...

The Cognitive Change Index (CCI) was reported to correlate significantly with objective cognitive tests and self-rated depression in our pilot study. In this extension study, we analyze content validity report additional assessments a larger dividuals. CCI is scale that measures self- (CCI-S) informant-rated (CCI-I) change an individual's cognition, consisting of 12 items memory, 5 executive function, 3 language. We calculated the overall score domain subscale scores for both CCI-S CCI-I 267...

depression prevalence in MCI have been conducted, but their results inconsistent such that no consensus has emerged.The objective of this study was to identify the best estimate and depressive symptoms any possible correlation.Methods: Following MOOSE criteria, a systematic search literature up October 2013 performed using Medline, Embase PsycINFO databases, with restrictions on year study.Inclusion criteria included: original research studies, studies reporting Depression English language...

Objective: We explored whether plasma α-syn be used as a potential biomarker for synucleinopathies. Materials and Methods: levels in from 54 Parkinson’s disease dementia (PDD) with Lewy bodies (DLB) patents, 31 Alzheimer’s (AD), 29 controls were measured by enzymelinked immunosorbent assay (ELISA). Results: The mean age of the synucleinopathies group, AD normal was 72.70, 74.26, 62 years old. median group 9.72 (4.41-25.30), 16.78 (7.68-51.41) 16.65 (10.37-32.72) ng/ml, respectively...

Abstract Background Tools for web‐based testing to detect cognitive impairment are still underdeveloped in Thailand. Our aim was generate a instrument assess and functional abilities explore its ability diagnosis of dementia MCI. Method We have developed web application assessment impairment. hoped that subjects or family members could use this tests at home as self‐screening. These included an electronic version the Thai Mental State Examination (e‐TMSE), clock drawing test, category verbal...

Abstract Background Obstructive sleep apnea (OSA) is associated with cognitive impairment (CI). We aimed to study subjective complaint (SCC) and objective scores, its relation polysomnography (PSG) parameters, in patients suspected of OSA. Method Patients OSA who were scheduled for PSG recruited. Cognition was assessed by the Montreal Cognitive Assessment (MoCA) Color Trails Test (CTT). The Memory index score (MIS) also calculated from MoCA. presence SCC asking directly using Change Index...

Abstract Background This study aims to investigate the characteristics of home cognitive stimulation activities for Thai patients with mild impairment (MCI) and dementia. Method A cross‐sectional, questionnaire‐based was conducted on diagnosis MCI Patients’ characteristics, ability use IT device or telecommunication technology, were collected. All divided calculated into sub‐scores cognitive, religion‐related, physical according its frequency. Result There 157 a mean age 76.2±7.9 years,...

Abstract Background Autoimmune encephalitis (AE) could present with heterogeneous clinical manifestations. Neurobehavioral symptoms were presented diversely in each type of AE and may be misdiagnosed psychiatric disorders. This study aimed to investigate categorize the manifestations evaluate treatment outcomes patients AE. Methods A retrospective chart review was done at Siriraj Hospital, Mahidol University. The data between 2009‐2022 extracted. Thirty‐seven diagnosed Clinical collected...