A5050601409- Viral Infections and Outbreaks Research
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Disaster Response and Management
- Antibiotic Resistance in Bacteria
- COVID-19 epidemiological studies
- Global Security and Public Health
- Reproductive tract infections research
- Vaccine Coverage and Hesitancy
- Syphilis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical and Antibiotic Environmental Impacts
- Adolescent Sexual and Reproductive Health
- Bacterial biofilms and quorum sensing
- HIV/AIDS Research and Interventions
- Data-Driven Disease Surveillance
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Misinformation and Its Impacts
- HIV/AIDS drug development and treatment
- Bacterial Infections and Vaccines
- Zoonotic diseases and public health
- Streptococcal Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Disaster Management and Resilience
Infectious Diseases Institute
2016-2025
Makerere University
2017-2025
Fort Portal Hospital
2021
Ministry of Health
2017-2020
Monterey Bay Aquarium Foundation
2020
World Health Organization
2020
Centers for Disease Control and Prevention
2020
United States Army Medical Research Institute of Infectious Diseases
2020
Emory University
2017
University of Minnesota
2017
Abstract Background Since the declaration of 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission enable timely detection, investigation, response event a confirmed country. We describe Uganda’s experience preparedness. Results On 4 August Uganda Ministry Health (MoH) activated Public Emergency Operations Centre (PHEOC) National Task Force (NTF) for...
Antimicrobial resistance (AMR) is an emerging public health crisis in Uganda. The World Health Organization (WHO) Global Action Plan recommends that countries should develop and implement National Plans for AMR. We describe the establishment of national AMR program Uganda present early microbial sensitivity results from program.The aim this study to a surveillance was developed perform systematic continuous collection, analysis, interpretation data.A qualitative description process progress...
Antimicrobial resistance (AMR) is a public health concern in Uganda. We sought to conduct an extended profiling of AMR burden at selected Ugandan tertiary hospitals. analyzed routine surveillance data collected between October 2020 and March 2023 from 10 The analysis was stratified according the hospital unit, age, gender, specimen type, time. Up 2754 isolates were recovered, primarily pus: 1443 (52.4%); urine: 1035 (37.6%); blood: 245 (8.9%). Most pathogens Staphylococcus aureus, 1020...
Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology factors associated MDR Escherichia coli (MDR E. coli) on Ugandan farms are not well known. This study investigated prevalence, resistance patterns carriage chicken farms. was isolated from each of 158 sampled. The disc diffusion method for susceptibility testing performed. Clinical breakpoints were interpreted according to Laboratory Standards Institute...
Background Antimicrobial irrational use and poor disposal in the human animal sectors promote antimicrobial resistance (AMR) environment as these antimicrobials their active ingredients, coupled with resistant microbes, are released into environment. While AMR containment programs well established Uganda, those water sector still need to be strengthened. Therefore, Ministry of Water Environment set out establish an surveillance program bolster One Health efforts for under National Action...
Global health security depends on effective surveillance for infectious diseases. In Uganda, resources are inadequate to support collection and reporting of data necessary an responsive system. We used a cross-cutting approach improve laboratory capacity in Uganda by leveraging existing pediatric inpatient malaria sentinel system collect expanded causes illness, facilitate development real-time surveillance, provide antimicrobial resistance. Capacity blood culture was established, along with...
Background Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant is recognized, extent its largely unknown. In 2016, World Health Organization’s Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated Uganda monitor trends. Objective This study characterizes and...
Objectives The emergence of multidrug-resistant Neisseria gonorrhoeae (NG) is a major global health threat necessitating response and control measures. NG antimicrobial resistance (AMR) surveillance data from sub-Saharan countries exceedingly limited. This paper aims to describe the establishment, design implementation standardised quality-assured gonococcal programme susceptibility patterns cultured isolates in Kampala, Uganda. Methods From March 2018 September 2019, using WHO Enhanced...
<h3>ABSTRACT</h3> <h3>Introduction:</h3> During the 2018–2020 Ebola virus disease (EVD) outbreak in Democratic Republic of Congo, risk communication and community engagement (RCCE) were prioritized geographic areas Uganda considered at high introduction EVD. To inform EVD preparedness Uganda, we evaluated perceptions prevention practices related to 6 districts Uganda. <h3>Methods:</h3> In March 2020, conducted a population-based survey purposively selected using multistage cluster sampling....
Trade and business, need for health care, visits to family, refugee support, insecurity in the Democratic Republic of Congo (DRC) drive population movement patterns among Rwanda, Uganda, provinces eastern DRC that are experiencing an Ebola virus disease outbreak.
Uganda's proximity to the tenth Ebola virus disease (EVD) outbreak in Democratic Republic of Congo (DRC) presents a high risk cross-border EVD transmission. Uganda conducted preparedness and risk-mapping activities strengthen capacity prevent importation spread from We adapted World Health Organization (WHO) Consolidated Preparedness Checklist assess 11 International Regulations domains at district level, health facilities, points entry; US Centers for Disease Control Prevention (CDC) Border...
Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology factors associated MDR Escherichia coli on Ugandan farms are not well known. This study investigated prevalence, resistance patterns E. carriage chicken farms. A total of 158 strains were isolated from The disc diffusion method for susceptibility testing was performed. Clinical breakpoints interpreted according to Laboratory Standards Institute guidelines....
Abstract Background Antimicrobial Resistance (AMR) is a major global health threat but its burden has not been extensively described in Uganda. We aimed to investigate the antibiotic resistance related mortality, length of hospital stays (LOS) and Disability Adjusted Life Years (DALYs). Methods This was retrospective study clinical records patients with infectious syndromes admitted at Arua, Jinja Mbale regional referral hospitals between October 2022 September 2023. Data abstracted from...
Aim of this study was to assess HIV-1 subtype distribution and prevalence transmitted mutations related antiretroviral drugs in Swaziland. According the WHO guidelines, 47 plasma samples from naive patients stored at HIV/AIDS National Reference Laboratory Mbabane between 2002 2003, before introduction therapy country, were studied. RNA extracted samples, RT protease regions pol gene amplified sequenced. The associated drug resistance defined as major or minor on basis recommendations...
Blood culture (BC) processes are critical to the utility of diagnostic testing, bloodstream infection (BSI) management, and antimicrobial resistance (AMR) surveillance. While Uganda has established BC guidelines, often laboratory practice does not meet desired standards. This compromises pathogen recovery, reliability susceptibility test utility. study assessed process outcomes among non-malarial febrile children below five years age at AMR surveillance sites in between 2017 2018. Secondary...
No abstract available.
The West Africa Ebola virus disease outbreak of 2014-2016 demonstrated that responses to viral hemorrhagic fever epidemics must go beyond emergency stopgap measures and should incorporate high-quality medical care clinical research. Optimal patient management is essential improving outcomes, it be implemented regardless geographical location or socioeconomic status. Coupling research with improved has a significant added benefit: Improved data quality can guide the development more effective...
Tackling antimicrobial resistance (AMR) is particularly challenging in low-resource settings such as Fort Portal Regional Referral Hospital (FPRRH) Western Uganda. Specific knowledge of local AMR epidemiology required to inform evidence-based improvement antibiotic stewardship measures the hospital. To address this, we combined existing susceptibility testing (AST) from FPRRH, with whole genome sequencing (WGS) 41 Staphylococcus aureus isolates (2017–2019). AST revealed 73 % (30 41) were...
<sec> <title>BACKGROUND</title> In 2017, Uganda implemented an electronic Integrated Disease Surveillance and Response System (eIDSR) to improve data completeness reporting timelines. However, the eIDSR system had limited functionality was on a small scale. The Ministry of Health (MOH), with support from Infectious Institute (IDI) Information Systems Program (HISP-Uganda), upgraded scaled up its implementation. </sec> <title>OBJECTIVE</title> We describe upgrade system, rollout, effect...
<sec> <title>UNSTRUCTURED</title> </sec>
In 2017, Uganda implemented an electronic Integrated Disease Surveillance and Response System (eIDSR) to improve data completeness reporting timelines. However, the eIDSR system had limited functionality was on a small scale. The Ministry of Health, with support from Infectious Institute, Makerere University, Health Information Systems Program Uganda, upgraded scaled up its implementation. This study describes process impact upgrading expanding implementation across additional districts....