A5077120372- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Genital Health and Disease
- Gut microbiota and health
- Parasites and Host Interactions
- Mobile Health and mHealth Applications
- Helminth infection and control
- Bladder and Urothelial Cancer Treatments
- Tuberculosis Research and Epidemiology
Makerere University
2019-2022
National Institutes of Health
2021
Infectious Diseases Institute
2021
Uganda Cancer Institute
2021
Mulago Hospital
2021
Abstract Introduction Uropathogenic E. coli is the leading cause of Urinary tract infections (UTIs), contributing to 80–90% all community-acquired and 30–50% hospital-acquired UTIs. Biofilm forming are associated with persistent chronic inflammation complicated or recurrent Biofilms provide an environment for poor antibiotic penetration horizontal transfer virulence genes which favors development Multidrug-resistant organisms (MDRO). Understanding biofilm formation antimicrobial resistance...
Background: The possible clinical application of specific cytokines and chemokines contributing to tumorigenesis the outcome several cancers has been reported. However, less invasive easily applicable biomarkers in prostate cancer diagnosis prognostication are still lacking. This study assessed levels plasma patients as potential for noninvasive early diagnosis. Methods: nine cytokines, IL-6, IL-8, IL-10, IL-1β, IL-17A, IL-2, M-CSF, IL-12 IFN-α, were detected by Luminex© liquid array-based...
<ns4:p><ns4:bold>Introduction: </ns4:bold>Uropathogenic <ns4:italic>Escherichia coli</ns4:italic> (UPEC) remains the most common cause of urinary tract infections (UTIs). They account for over 80-90% all community-acquired and 30-50% hospital-acquired UTIs. <ns4:italic>E. strains have been found to belong evolutionary origins known as phylogenetic groups. In 2013, Clermont classified coli </ns4:italic>strains into eight groups using quadruplex PCR method. The aim this study was identify UPEC...
Abstract Introduction: Uropathogenic E. coli is the leading cause of Urinary tract infections (UTIs), contributing to 80-90% all community-acquired and 30-50% hospital-acquired UTIs. Biofilm forming are associated with persistent chronic inflammation complicated or recurrent Biofilms provide an environment for poor antibiotic penetration horizontal transfer virulence genes which favors development Multidrug-resistant organisms (MDRO). Understanding biofilm formation antimicrobial resistance...
Background Prostate cancer is the second most common among men in Uganda, with over 2086 incident cases 2018. This study's objective was to report clinical characteristics and primary management of diagnosed prostate at Uganda Cancer Institute from 1st January 2015 31st December 2019. Methods Records all 2019 were reviewed. Clinical treatment recorded. Risk categorization done using European Society for Medical Oncology risk group classification. Results A total 874 medical records...
Programmed death 1 (PD-1)/programmed death-ligand (PD-L1)-targeted immunotherapies have become a new mode of treatment for several tumours; however, there is limited evidence on the expression and prognostic value PD-1/PD-L1 in prostate cancer, especially African men.Plasma concentrations PD-L1/PD-1 were assessed using enzyme-linked immunosorbent assay patients with cancer normal healthy controls at Uganda Cancer Institute. The associations between plasma concentration levels serum...
Although a third of people with tuberculosis (TB) are estimated to be coinfected helminths, the prevalence is largely unknown among drug-resistant TB (DR-TB). We determined helminth coinfection DR-TB in Uganda.In multicenter, cross-sectional study, eligible Ugandan adults confirmed were consecutively enrolled between July December 2021 at 4 treatment centers. Sociodemographic data collected using questionnaire. Participants underwent anthropometric and blood pressure measurements, samples...
Abstract Introduction: Uropathogenic E. coli is the leading cause of Urinary tract infections (UTIs), contributing to 80-90% all community-acquired and 30-50% hospital-acquired UTIs. Biofilm forming are associated with persistent chronic inflammation complicated or recurrent Biofilms provide an environment for poor antibiotic penetration horizontal transfer virulence genes which favors development Multidrug-resistant organisms (MDRO). Understanding biofilm formation antimicrobial resistance...
Abstract Background Prostate cancer is the second most common among men in Uganda, with over 2086 incident cases 2018. This study’s objective was to report clinical characteristics and primary management of diagnosed prostate at Uganda Cancer Institute from 1 st January 2015 31 December 2019. Methods Records all 2019 were reviewed. Clinical treatment recorded. Risk categorization done using European Society for Medical Oncology risk group classification. Results total 874 medical records...
Abstract Background The programmed death 1 (PD1)/programmed death-ligand (PDL1) targeted immunotherapies have become a new mode of treatment for several tumours; however, there is limited evidence on the expression and prognostic value PD1/PDL1 in prostate cancer, especially African men. Methods plasma concentrations PD-L1/PD1 were assessed using Enzyme-Linked Immunosorbent Assay patients with cancer normal healthy controls at Uganda Cancer Institute. association between concentration levels...