A5011472628- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Diabetes and associated disorders
- Complement system in diseases
- NF-κB Signaling Pathways
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
- Salmonella and Campylobacter epidemiology
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Artificial Immune Systems Applications
- Gut microbiota and health
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Escherichia coli research studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Diseases and Glomerulopathies
- Immune responses and vaccinations
- Single-cell and spatial transcriptomics
- Preterm Birth and Chorioamnionitis
Indian Institute of Science Education and Research Pune
2020-2024
Institute of Oceanology
2024
University of Chinese Academy of Sciences
2024
Qingdao National Laboratory for Marine Science and Technology
2024
University of New Mexico
2024
Baylor College of Medicine
2024
Indian Institute of Science Education and Research Berhampur
2022-2024
Indian Institute of Science Education and Research Mohali
2022-2024
Indian Institute of Science Education and Research Kolkata
2022-2024
Indian Institute of Science Education and Research, Bhopal
2022-2024
Sepsis is a consequence of systemic bacterial infections leading to hyper activation immune cells by products resulting in enhanced release mediators inflammation. Endotoxin (LPS) major component the outer membrane Gram negative bacteria and critical factor pathogenesis sepsis. Development antagonists that inhibit storm inflammatory molecules blocking Toll like receptors (TLR) has been main stay research efforts. We report here filarial glycoprotein binds murine macrophages human monocytes...
The human peripheral leukocyte subset composition depends on genotype variation and pre-natal post-natal environmental influence diversity. We quantified this in adults neonates, compared the median values dispersal ranges of various subsets them. confirmed higher frequencies monocytes regulatory T cells (Tregs), similar neutrophils, lower CD8 cells, NKT B1 B gamma-delta neonatal umbilical cord blood. Unlike previous reports, we found eosinophils CD4:CD8 ratios, iNKT CD4 NK neonates....
Background: Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator this pathway, account for distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well with disease activity and their functional characterization required. Methods: Of 781 patients <18-year-old aHUS in nationwide database from 2007 2018, 436...
The progeny of T lymphocytes responding to immunization mostly die rapidly, leaving a few long-lived survivors functioning as immune memory. Thus, control this choice death versus survival is critical for There are indications that reactive radicals may be involved in pathway. We now show that, mice lacking inducible nitric oxide synthase (iNOS), higher frequencies both CD4 and CD8 memory cells persist response immunization, even when iNOS+/+ APCs used immunization. Postactivation cell by...
We have maleylated proteins to target macrophage-specific scavenger receptors and used this system study changes in the epitopes immunogenicity of such proteins. show that maleylation diphtheria toxoid (DT) induces targeting macrophage enhances its immunogenicity. DT does not evoke detectable serum Ab responses upon injection as soluble protein. However, (mDT) generate a significant response. Furthermore, immunization with mDT leads better T cell proliferative response vitro than can...
Macrophages from X-linked immunodeficient (xid) mice lacking functional Bruton's tyrosine kinase (Btk) show poor NO induction and enhanced IL-12 induction, contribute to delayed clearance of injected microfilaria (mf) in vivo. We now that Btk is involved other macrophage effector functions, such as bactericidal activity secretion proinflammatory cytokines (TNF-alpha, IL-1beta), but not the T cell-directed cytokine IL-12. Induction some transcriptional regulators NF-kappaB family, crucial for...
Abstract The Nef protein of HIV-1 is essential for its pathogenicity and known to down-regulate MHC expression on infected cell surfaces. We now show that also redistributes the costimulatory molecules CD80 CD86 away from surface in human monocytic U937 line as well mouse macrophages dendritic cells. Furthermore, HIV-1-infected cells blood-derived a similar loss CD86. colocalizes with class I (MHCI), CD80, intracellular compartments, binds both Some mutants defective MHCI down-modulation,...
Hepatitis E virus infection (HEV) is a major cause of acute viral hepatitis in the developing world. The immunopathology HEV infections has not yet been elucidated. noncytopathic, and therefore, liver injury may be attributed to immune-mediated damage by cytotoxic T cells natural killer cells. Therefore, we studied nature immune involved HEV-induced using immunohistochemistry biopsies taken from patients with failure demonstrated significant infiltration activated CD8(+) containing...
Farm women play an important role in agrarian economy. This study aimed to explore the of entrepreneurship empowering rural eastern Indian state Bihar, where literacy rates are low and socio-economic opportunities limited. The research was conducted Bhagalpur district during 2019-20, covering a random sample 80 entrepreneurs, 20 each engaged mushroom cultivation, goat rearing, dairy farming, stitching enterprises. Using social empowerment as well agriculture index, composite measure, this...
Antigen-presenting cells (APCs) are expected to present peptides from endocytosed proteins via major histocompatibility complex (MHC) class II (MHCII) molecules T cells. However, a large proportion of purified MHCII derived cytosolic self-proteins making the pathway peptide loading onto critical relevance in regulation immune self-tolerance. We show that cytoplasmic either introduced or expressed cytoplasm first detectable as MHCII-peptide complexes LAMP-1+ lysosomes, prior their delivery...
Significance Since fever is frequently a response to infection, immune responses likely occur commonly at temperatures. Are temperatures detected by cells, what molecular pathways are involved in this sensing, and the functional consequences? Our data show that CD4 T lymphocytes detect moderate temperature. A TRPV channel-mediated pathway involving Notch activation leads Th2 skewing of effector cell response. However, antigen presenting dendritic cells stimulate turn, temperature overproduce...
The mechanisms responsible for differential commitment of effector T cells to the production either IL-4/5/10 group or IL-2/IFN-γ lymphokines during an immune response have not yet been clearly elucidated. We used Salmonella typhimurium as a model murine bacterial parasite in BALB/c mice live-cell versus killed-cell immunization and looked at terms delayed type hypersensitivity (DTH), IgG subclass distribution serum antibody response, antigen-specific cell proliferation lymphokine secretion....
Abstract Peptides from extracellular proteins presented on MHC class II are mostly generated and loaded in endolysosomal compartments, but the major pathways responsible for loading peptides APC-endogenous sources as yet unclear. In this study, we show that molecules present such OVA or conalbumin introduced into cytoplasm by hyperosmotic pinosome lysis, with efficiencies comparable to their presentation via fluid-phase endocytosis. This cytosolic pathway is sensitive proteasomal inhibitors,...