A5080889629- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Congenital heart defects research
- Atherosclerosis and Cardiovascular Diseases
- Virus-based gene therapy research
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- RNA modifications and cancer
- CAR-T cell therapy research
- Resilience and Mental Health
- Calcium signaling and nucleotide metabolism
- Pluripotent Stem Cells Research
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Inhalation and Respiratory Drug Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- Diabetes and associated disorders
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
University of Cambridge
2025
Victor (Japan)
2025
Emory University
2020-2022
Medical College of Wisconsin
2022
Children's Hospital of Wisconsin
2022
University of Pittsburgh
2021
Cincinnati Children's Hospital Medical Center
2020
University of Cincinnati Medical Center
2020
Hoshi University
2015
National Institute of Immunology
2014
A wide spectrum of clinical manifestations has become a hallmark the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although immunological underpinnings diverse disease outcomes remain to be defined. We performed detailed characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation shared...
Abstract Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of COVID-19 pandemic 2–5 . More recently, these responses have emergence self-reactive antibodies pathologic potential 6–10 , although their origins and resolution remained unclear 11 Previously, we others identified extrafollicular B cell activation, a pathway formation new autoreactive in chronic autoimmunity 12,13 as dominant feature severe critical (refs. 14–18 )....
Aging results in profound immune dysfunction, resulting the decline of vaccine responsiveness previously attributed to irreversible defects system. In addition increased interleukin-6 (IL-6), we found aged mice exhibit systemic IL-10 that requires forkhead box P3-negative (FoxP3-), but not FoxP3+, CD4+T cells. Most IL-10-producing cells manifested a T follicular helper (Tfh) phenotype and required Tfh cytokines IL-6 IL-21 for their accrual, so refer them as Tfh10 was also maintain normal...
Abstract An emerging feature of COVID-19 is the identification autoreactivity in patients with severe disease that may contribute to pathology, however origin and resolution these responses remain unclear. Previously, we identified strong extrafollicular B cell activation as a shared immune response between both advanced rheumatic disease. In autoimmune settings, this pathway associated relaxed peripheral tolerance antibody secreting compartment generation de novo autoreactive responses....
Abstract/Introduction A wide clinical spectrum has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic, although its immunologic underpinnings remain to be defined. We have performed deep characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation as previously described autoimmune settings. Extrafollicular...
Aging leads to structural and functional deterioration of the heart, reducing its capacity withstand internal external stressors consequently increasing risk heart failure. Exercise is a potent modulator cardiovascular metabolic health, offering numerous physiological benefits that can persist throughout aging process. Studies suggest exercise decelerate age-related cardiac mitigate In this review, we discuss recent advances in our understanding exercise-mediated molecular cellular...
Abstract SARS-CoV-2 has caused over 100,000,000 cases and almost 2,500,000 deaths globally. Comprehensive assessment of the multifaceted antiviral Ab response is critical for diagnosis, differentiation severity, characterization long-term immunity, especially as COVID-19 vaccines become available. Severe disease associated with early, massive plasmablast responses. We developed a multiplex immunoassay from serum/plasma acutely infected convalescent patients prepandemic postpandemic healthy...
Bicuspid aortic valve (BAV) with ∼1%–2% prevalence is the most common congenital heart defect (CHD). It frequently results in disease and aorta dilation a major cause of adult cardiac surgery. BAV genetically linked to rare left-heart obstructions (left ventricular outflow tract [LVOTOs]), including hypoplastic left syndrome (HLHS) coarctation (CoA). Mouse human studies indicate LVOTO heterogeneous complex genetic etiology. Homozygous mutation Pcdha protocadherin gene cluster mice can BAV,...
SARS-CoV-2 has caused over 36,000,000 cases and 1,000,000 deaths globally. Comprehensive assessment of the multifaceted anti-viral antibody response is critical for diagnosis, differentiation severe disease, characterization long-term immunity. Initial observations suggest that disease associated with higher levels greater B cell/plasmablast responses. A multi-antigen immunoassay to define complex serological landscape clinical associations essential. We developed a multiplex evaluated...
Mammalian cardiomyocyte maturation entails phenotypic and functional optimization during the late fetal postnatal phases of heart development, both processes driven coordinated by complex gene regulatory networks. Cardiomyocytes derived from human induced pluripotent stem cells (iPSCs) are heterogenous immature, barely resembling their adult in vivo counterparts. To characterize relevant developmental programs states iPSC-cardiomyocyte differentiation, we performed single-cell transcriptomic...
Abstract A TLR7-IFNg driven IL-21 mediated unique extra-follicular pathway of ASC differentiation activated naïve B cells through an intermediary DN2 cell subset has been characterized in pathogenesis SLE. It correlated to distinct priming by the presence SLE disease signatures which indicates towards convergence TLR, and cytokine signaling along with BCR expansion peripheral Thus, we hypothesize that combinations innate, cytokines antigen stimuli cause maneuvering disease-related epigenetic...