A5015074894- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Antifungal resistance and susceptibility
- Respiratory and Cough-Related Research
- Immunotherapy and Immune Responses
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Cancer Immunotherapy and Biomarkers
- Electroconvulsive Therapy Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lymphatic Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Rabies epidemiology and control
- Platelet Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Thermal Regulation in Medicine
- Cardiovascular Effects of Exercise
- Microscopic Colitis
- Dermatology and Skin Diseases
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Clostridium difficile and Clostridium perfringens research
Emory University
2019-2024
Atlanta VA Health Care System
2024
University of Atlanta
2022
University of Florida
2017-2019
UF Health Shands Hospital
2018
Abstract Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of COVID-19 pandemic 2–5 . More recently, these responses have emergence self-reactive antibodies pathologic potential 6–10 , although their origins and resolution remained unclear 11 Previously, we others identified extrafollicular B cell activation, a pathway formation new autoreactive in chronic autoimmunity 12,13 as dominant feature severe critical (refs. 14–18 )....
Clinical ImplicationsWe describe the cases of identical twins with allergic bronchopulmonary aspergillosis, but only 1 them received biologic therapies. We used their genetic homogeneity as a basis for assessing effectiveness dupilumab in treating aspergillosis. Allergic aspergillosis (ABPA) occurs from hypersensitivity reaction to fungus Aspergillus and shares some pathogenesis asthma.1Agarwal R. Chakrabarti A. Shah Gupta D. Meis J.F. Guleria et al.Allergic aspergillosis: review literature...
ABSTRACT Post-acute sequelae of SARS-CoV-2 (SARS2) infection (PASC) is a heterogeneous condition, but the main viral drivers are unknown. Here, we use MENSA, Media Enriched with Newly Synthesized Antibodies, secreted exclusively from circulating human plasmablasts, to provide an immune snapshot that defines underlying triggers. We proof-of-concept testing MENSA technology can capture new host response accurately diagnose acute primary and breakthrough infections when known SARS2 virus or...
Rhabdomyolysis is characterised by muscle breakdown with release of damaging proteins that can have devastating consequences. Acute influenza infection being increasingly recognised as an underlying aetiology. We report unusual case severe rhabdomyolysis acute renal failure due to A improved high-dose oseltamivir and intravenous fluids. In our case, we also noticed a temporal relation between fever spikes subsequent increase in serum creatine kinase. The precise mechanism the rise...
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well contribution of disease-induced abnormalities, remain largely unexplored. In this study, we conducted a comprehensive serological and analysis patients with autoimmune systemic lupus erythematosus (SLE) who received Wuhan-Hu-1 monovalent disease 2019 vaccine. Our findings revealed that SLE...
Within 8 weeks of primary Clostridioides difficile infection (CDI), as many 30% patients develop recurrent disease with the associated risks multiple relapses, morbidity, and economic burden. There are no clear clinical correlates or validated biomarkers that can predict recurrence during infection. This study demonstrated potential a simple test for identifying hospitalized CDI at low risk recurrence. Forty-six were enrolled Emory University Hospitals. Samples serum novel matrix from...
Abstract Novel mRNA vaccines have resulted in a reduced number of SARS-CoV-2 infections and hospitalizations. Yet, there is paucity studies regarding their effectiveness on immunocompromised autoimmune subjects. In this study, we enrolled subjects naïve to from two cohorts healthy donors (HD, n=56) systemic lupus erythematosus (SLE, n=69). Serological assessments circulating antibodies revealed significant reduction potency breadth neutralization the SLE group, only partially rescued by 3 rd...
A 26 year old female presented for recurrent blood tinged sputum during the previous with development of frank hemoptysis three days prior to admission. Diffuse alveolar hemorrhage (DAH) was confirmed serial lavages. The patient had no history autoimmune disease, vascular thrombosis or pregnancy morbidity including miscarriages pre-eclampsia. High dose steroids were initiated along noninvasive ventilatory support. Transthoracic echocardiogram showed severe mitral regurgitation and a...
We report a case of hospitalised patient who developed probable serotonin toxicity shortly after the initiation linezolid in whom selective reuptake inhibitor (SSRI) escitalopram had been recently discontinued. On day 2 administration, reported severe anxiety and was observed to have full body jerking twitching motions without mental status change. Notably, concomitantly receiving antidepressant, trazodone benzodiazepine, clonazepam possibly affecting severity manifestations toxicity....
<title>Abstract</title> Post-acute sequelae of SARS-CoV-2 (SARS2) infection (PASC) is a heterogeneous condition, but the main viral drivers are unknown. Here, we use MENSA, Media Enriched with Newly Synthesized Antibodies, secreted exclusively from circulating human plasmablasts, to provide an immune snapshot that defines underlying triggers. We proof-of-concept testing MENSA technology can capture new host response accurately diagnose acute primary and breakthrough infections when known...
Allergic bronchopulmonary aspergillosis (ABPA) is a disease resulting from an overactive type 2 response to
Learning points for clinicians• Hypertriglyceridemia is an important cause of acute pancreatitis and a level >1000 mg/dl has been strongly associated with pancreatitis.• Severe hypertriglyceridemia can be lipemia retinalis, lipemic serum (Creamish-yellowish colored serum).• Treatment severe induced includes IV fluids, Insulin, Heparin plasmapheresis.• Chyloptysis mostly seen in cases abnormal lymphatics (Lymphangiectasis, Behcet's disease) or thoracic duct abnormalities/obstruction (LAM, Trauma).