A5024242683- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Salmonella and Campylobacter epidemiology
- Animal Virus Infections Studies
- Rheumatoid Arthritis Research and Therapies
- Kawasaki Disease and Coronary Complications
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Escherichia coli research studies
- Biosimilars and Bioanalytical Methods
- Immunotherapy and Immune Responses
- Intensive Care Unit Cognitive Disorders
University of Maryland, Baltimore
2018-2019
Abstract Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of COVID-19 pandemic 2–5 . More recently, these responses have emergence self-reactive antibodies pathologic potential 6–10 , although their origins and resolution remained unclear 11 Previously, we others identified extrafollicular B cell activation, a pathway formation new autoreactive in chronic autoimmunity 12,13 as dominant feature severe critical (refs. 14–18 )....
While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae (PASC) remain less clear. Due to the wide array PASC presentations, understanding if specific disease features associate discrete immune processes and therapeutic opportunities is important. Here we profile patients in recovery phase via proteomics screening machine learning find signatures ongoing antiviral B cell development, immune-mediated fibrosis, markers death but not...
Abstract An emerging feature of COVID-19 is the identification autoreactivity in patients with severe disease that may contribute to pathology, however origin and resolution these responses remain unclear. Previously, we identified strong extrafollicular B cell activation as a shared immune response between both advanced rheumatic disease. In autoimmune settings, this pathway associated relaxed peripheral tolerance antibody secreting compartment generation de novo autoreactive responses....
Toxic shock syndrome (TSS) is capable of inducing life-threatening fever, rash, and systemic organ failure, though the specific mechanisms behind these symptoms remain poorly understood. Staphylococcal enterotoxin B (SEB) other superantigens have shown to be important factors in TSS, promoting cross-linking between T cell receptors (TCR) major histocompatibility complexes (MHC) which results overwhelming activation, proliferation, cytokine production. The resulting pro-inflammatory cascade,...
Human-restricted Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever-a life-threatening disease great global health significance, particularly in developing world. Ty21a an oral live-attenuated vaccine that protects against development part by inducing robust T cell responses, among which multifunctional CD8+ cytotoxic lymphocytes (CTL) play important role. Following vaccination, a significant component adult CTL have shown to be targeted S. antigen presented...
Typhoid fever is a life-threatening disease caused by the human-restricted pathogen Salmonella enterica serovar Typhi (S. Typhi). The oral live attenuated Ty21a typhoid vaccine protects against this severe eliciting robust, multifunctional cell-mediated immunity (CMI), shown to be associated with protection in wild-type S. challenge studies. induces Typhi-responsive CD8+ and CD4+ T cells but little known about response children. To address important gap knowledge, we have used mass cytometry...
Hydroxychloroquine (HCQ) and methotrexate (MTX) are common antirheumatic drugs used chronically by patients with systemic lupus erythematosus (SLE) rheumatoid arthritis (RA) (1, 2). Therapeutic drug monitoring (TDM) of HCQ MTX provides critical compliance information, but typically requires venipuncture shipment refrigerated blood samples to the clinical laboratory. Capillary collection finger prick offers a convenient alternative venipuncture. The long-term stability capillary collected...
Abstract While significant attention has been paid to the immunologic determinants of disease states associated with COVID-19 1,2 , their contributions post-acute sequelae (PASC) remain less clear 3-5 . Due wide array PASC presentations 6 it is critical understand if specific features are discrete immune processes, and whether those processes may be therapeutically targeted. To this end, we performed serological characterization patients in early recovery phase across a breadth symptomatic...