A5021756706- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Atrial Fibrillation Management and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Health and Biochemistry
- Blood properties and coagulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Dermatological and COVID-19 studies
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Acute Myocardial Infarction Research
- Retinal and Optic Conditions
Emory University
2015-2025
GlaxoSmithKline (United States)
2024
Emory Healthcare
2023-2024
Chongqing Electromechanical Holdings (China)
2021
St. Joseph's Hospital
2020
Saint Joseph's Hospital
2020
Grifols (Spain)
2020
Emory University Hospital
2016-2020
Institute for Transfusion Medicine
2018
Yale University
2009-2013
Abstract Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of COVID-19 pandemic 2–5 . More recently, these responses have emergence self-reactive antibodies pathologic potential 6–10 , although their origins and resolution remained unclear 11 Previously, we others identified extrafollicular B cell activation, a pathway formation new autoreactive in chronic autoimmunity 12,13 as dominant feature severe critical (refs. 14–18 )....
Abstract Human CMV infection is controlled by T cell-mediated immunity and in immunosuppressed transplant patients it associated with acute allograft rejection as well chronic vasculopathy. infects endothelial cells (EC) thought that CMV-specific host immune responses to infected EC contribute rejection. In vitro, CD4+ from CMV-positive donors (but not CMV-negative donors) are readily activated CMV-infected allogeneic EC, although unclear how activate self-class II MHC-restricted memory...
The coronavirus disease (COVID-19) pandemic has threatened millions of lives worldwide with severe systemic inflammation, organ dysfunction, and thromboembolic disease. Within our institution, many critically ill COVID-19-positive patients suffered major thrombotic events, prompting clinicians to evaluate hypercoagulability outside traditional coagulation testing.We determined the prevalence fibrinolysis shutdown via rotational thromboelastometry (ROTEM, Instrumentation Laboratories,...
Abstract The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2 infection remains poorly understood. Endothelial damage and microvascular thrombosis have been identified as drivers COVID-19 severity, yet the mechanisms underlying these processes remain elusive. Here we show alterations in fluid shear stress-responsive pathways critically ill adults compared to non-COVID using a multiomics approach. Mechanistic in-vitro studies, microvasculature-on-chip devices,...
Microcirculation (2010) 17, 367–380. doi: 10.1111/j.1549-8719.2010.00038.x Abstract Objective: Pericytes are critical cellular components of the microvasculature that play a major role in vascular development and pathologies, yet their study has been hindered by lack standardized method for isolation growth. Here we report culturing human pericytes from readily available tissue source, placenta, provide thorough characterization resultant cell populations. Methods: We developed an optimized...
During acute inflammation, neutrophil recruitment into extravascular tissue requires tethering and rolling on cytokine-activated endothelial cells (ECs), tight adhesion, crawling towards EC junctions transendothelial migration (TEM). Following TEM, neutrophils must still traverse the subendothelial basement membrane network of pericytes (PCs). Until recently, contribution PC layer to was largely ignored. Here we analyze human interactions with interleukin (IL)-1β-activated monolayers,...
Recent data suggests an association between blood hyperviscosity and both propensity for thrombosis disease severity in patients with COVID-19. This raises the possibility that increased viscosity may contribute to endothelial damage multiorgan failure COVID-19, therapeutic plasma exchange (TPE) decrease improve patient outcomes. Here we sought share our experience using TPE first 6 treated COVID-19-associated hyperviscosity.Six critically ill COVID-19 levels ranging from 2.6 4.2 centipoise...
Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. PASC has highly variable clinical presentations, likely multiple molecular subtypes, but it remains poorly understood from a mechanistic standpoint. This hampers the development rationally targeted therapeutic strategies. The NIH-sponsored “Researching COVID to Enhance Recovery” (RECOVER) initiative several...
While the inhibitory receptor FcγRIIB has been shown to be upregulated on activated CD8+ T cells in both mice and humans, its effect cell fate during infection not fully elucidated. We identified an increase FcγRIIB-expressing patients with COVID-19 relative healthy controls as well mouse models of viral infection. Despite well-known role Fc receptor, also ligates immunosuppressive cytokine Fgl2, resulting apoptosis. Both chronic LCMV humans resulted a significant plasma Fgl2. Transfer into...
Objective— Cell-mediated immune responses in peripheral tissues begin with T cell infiltration through endothelial (EC) microvessels and accumulation the perivascular space occupied by pericytes (PC). Here, we investigate how human cells interact PC. Methods Results— We compared placental PC autologous umbilical vein EC. Cultured express lower levels of major histocompatibility complex (MHC) positive costimulatory molecules but higher negative than do Unlike EC, interferon-γ-treated MHC...
RBC alloimmunization represents a significant immunological challenge for patients requiring lifelong transfusion support. The majority of clinically relevant non-ABO(H) blood group antigens have been thought to drive antibody formation through T cell–dependent immune pathways. Thus, we initially sought define the role CD4+ cells in alloantibodies KEL, one leading causes hemolytic reactions. Unexpectedly, our findings demonstrated that KEL RBCs actually possess ability induce independent or...